Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls

Handle URI:
http://hdl.handle.net/10754/561845
Title:
Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls
Authors:
Hossain, Shaolie S.; Hossainy, Syed F A; Bazilevs, Yuri; Calo, Victor M. ( 0000-0002-1805-4045 ) ; Hughes, Thomas Jr R
Abstract:
The majority of heart attacks occur when there is a sudden rupture of atherosclerotic plaque, exposing prothrombotic emboli to coronary blood flow, forming clots that can cause blockages of the arterial lumen. Diseased arteries can be treated with drugs delivered locally to vulnerable plaques. The objective of this work was to develop a computational tool-set to support the design and analysis of a catheter-based nanoparticulate drug delivery system to treat vulnerable plaques and diffuse atherosclerosis. A threedimensional mathematical model of coupled mass transport of drug and drug-encapsulated nanoparticles was developed and solved numerically utilizing isogeometric finite element analysis. Simulations were run on a patient-specific multilayered coronary artery wall segment with a vulnerable plaque and the effect of artery and plaque inhomogeneity was analyzed. The method captured trends observed in local drug delivery and demonstrated potential for optimizing drug design parameters, including delivery location, nanoparticle surface properties, and drug release rate. © Springer-Verlag 2011.
KAUST Department:
Applied Mathematics and Computational Science Program; Physical Sciences and Engineering (PSE) Division; Environmental Science and Engineering Program; Numerical Porous Media SRI Center (NumPor)
Publisher:
Springer Verlag
Journal:
Computational Mechanics
Issue Date:
20-Aug-2011
DOI:
10.1007/s00466-011-0633-2
Type:
Article
ISSN:
01787675
Sponsors:
This work was partially supported by research Grant No. UTA05-663 from Abbott Vascular Inc. Support of the Texas Advanced Research Program of the Texas Higher Education Coordinating Board through Grant No. 003658-0025-2006 and Portuguese CoLab Grant No. 04A is also gratefully acknowledged.
Appears in Collections:
Articles; Environmental Science and Engineering Program; Applied Mathematics and Computational Science Program; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorHossain, Shaolie S.en
dc.contributor.authorHossainy, Syed F Aen
dc.contributor.authorBazilevs, Yurien
dc.contributor.authorCalo, Victor M.en
dc.contributor.authorHughes, Thomas Jr Ren
dc.date.accessioned2015-08-03T09:32:18Zen
dc.date.available2015-08-03T09:32:18Zen
dc.date.issued2011-08-20en
dc.identifier.issn01787675en
dc.identifier.doi10.1007/s00466-011-0633-2en
dc.identifier.urihttp://hdl.handle.net/10754/561845en
dc.description.abstractThe majority of heart attacks occur when there is a sudden rupture of atherosclerotic plaque, exposing prothrombotic emboli to coronary blood flow, forming clots that can cause blockages of the arterial lumen. Diseased arteries can be treated with drugs delivered locally to vulnerable plaques. The objective of this work was to develop a computational tool-set to support the design and analysis of a catheter-based nanoparticulate drug delivery system to treat vulnerable plaques and diffuse atherosclerosis. A threedimensional mathematical model of coupled mass transport of drug and drug-encapsulated nanoparticles was developed and solved numerically utilizing isogeometric finite element analysis. Simulations were run on a patient-specific multilayered coronary artery wall segment with a vulnerable plaque and the effect of artery and plaque inhomogeneity was analyzed. The method captured trends observed in local drug delivery and demonstrated potential for optimizing drug design parameters, including delivery location, nanoparticle surface properties, and drug release rate. © Springer-Verlag 2011.en
dc.description.sponsorshipThis work was partially supported by research Grant No. UTA05-663 from Abbott Vascular Inc. Support of the Texas Advanced Research Program of the Texas Higher Education Coordinating Board through Grant No. 003658-0025-2006 and Portuguese CoLab Grant No. 04A is also gratefully acknowledged.en
dc.publisherSpringer Verlagen
dc.subjectAtherosclerosisen
dc.subjectDrug deliveryen
dc.subjectIsogeometricen
dc.subjectNanoparticleen
dc.subjectTransporten
dc.titleMathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery wallsen
dc.typeArticleen
dc.contributor.departmentApplied Mathematics and Computational Science Programen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentEnvironmental Science and Engineering Programen
dc.contributor.departmentNumerical Porous Media SRI Center (NumPor)en
dc.identifier.journalComputational Mechanicsen
dc.contributor.institutionInstitute for Computational Engineering and Sciences, University of Texas at Austin, 1 University Station, C0200, Austin, TX 78712, United Statesen
dc.contributor.institutionNew Business Venture, Abbott Vascular, MS 232, 3200, Lakeside Drive, Santa Clara, CA 95054, United Statesen
dc.contributor.institutionDepartment of Structural Engineering, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093, United Statesen
kaust.authorCalo, Victor M.en
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