Effect of passivation on the sensitivity and stability of pentacene transistor sensors in aqueous media

Handle URI:
http://hdl.handle.net/10754/561788
Title:
Effect of passivation on the sensitivity and stability of pentacene transistor sensors in aqueous media
Authors:
Khan, Hadayat Ullah; Jang, Junhyuk; Kim, Jangjoo; Knoll, Wolfgang
Abstract:
Charge-detecting biosensors have recently become the focal point of biosensor research, especially research onto organic thin-film transistors (OTFTs), which combine compactness, a low cost, and fast and label-free detection to realize simple and stable in vivo diagnostic systems. We fabricated organic pentacene-based bottom-contact thin-film transistors with an ultra-thin insulating layer of a cyclized perfluoro polymer called CYTOP (Asahi Glass Co., Tokyo, Japan) on SiO2 for operation in aqueous media. The stability and sensitivity of these transistor sensors were examined in aqueous buffer media with solutions of variable pH levels after the passivation of perfluoro polymers with thicknesses ranging from 50 to 300nm. These transistor sensors were further modified with an ultra-thin film (5nm) functional layer for selective BSA/antiBSA detection in aqueous buffer media, demonstrating a detection capability as low as 500nM of concentrated antiBSA. The dissociation constant from the antiBSA detection results was 2.1×10-6M. Thus, this study represents a significant step forward in the development of organic electronics for a disposable and versatile chemical and bio-sensing platform. © 2011 Elsevier B.V.
KAUST Department:
Materials Science and Engineering Program; Physical Sciences and Engineering (PSE) Division
Publisher:
Elsevier
Journal:
Biosensors and Bioelectronics
Issue Date:
Jun-2011
DOI:
10.1016/j.bios.2011.03.031
PubMed ID:
21546238
Type:
Article
ISSN:
09565663
Sponsors:
H.U.K. acknowledges the financial support from IRTG/1404 (funded by the DFG) and the Max-Planck Society (Germany). J.-J.K. acknowledges the WCU (R31-2008-000-10075-0) and BSR (R15-2008-006-01001-0) support through the NRF funded by the Ministry of Education, Science and Technology of Korea.
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Materials Science and Engineering Program

Full metadata record

DC FieldValue Language
dc.contributor.authorKhan, Hadayat Ullahen
dc.contributor.authorJang, Junhyuken
dc.contributor.authorKim, Jangjooen
dc.contributor.authorKnoll, Wolfgangen
dc.date.accessioned2015-08-03T09:04:38Zen
dc.date.available2015-08-03T09:04:38Zen
dc.date.issued2011-06en
dc.identifier.issn09565663en
dc.identifier.pmid21546238en
dc.identifier.doi10.1016/j.bios.2011.03.031en
dc.identifier.urihttp://hdl.handle.net/10754/561788en
dc.description.abstractCharge-detecting biosensors have recently become the focal point of biosensor research, especially research onto organic thin-film transistors (OTFTs), which combine compactness, a low cost, and fast and label-free detection to realize simple and stable in vivo diagnostic systems. We fabricated organic pentacene-based bottom-contact thin-film transistors with an ultra-thin insulating layer of a cyclized perfluoro polymer called CYTOP (Asahi Glass Co., Tokyo, Japan) on SiO2 for operation in aqueous media. The stability and sensitivity of these transistor sensors were examined in aqueous buffer media with solutions of variable pH levels after the passivation of perfluoro polymers with thicknesses ranging from 50 to 300nm. These transistor sensors were further modified with an ultra-thin film (5nm) functional layer for selective BSA/antiBSA detection in aqueous buffer media, demonstrating a detection capability as low as 500nM of concentrated antiBSA. The dissociation constant from the antiBSA detection results was 2.1×10-6M. Thus, this study represents a significant step forward in the development of organic electronics for a disposable and versatile chemical and bio-sensing platform. © 2011 Elsevier B.V.en
dc.description.sponsorshipH.U.K. acknowledges the financial support from IRTG/1404 (funded by the DFG) and the Max-Planck Society (Germany). J.-J.K. acknowledges the WCU (R31-2008-000-10075-0) and BSR (R15-2008-006-01001-0) support through the NRF funded by the Ministry of Education, Science and Technology of Korea.en
dc.publisherElsevieren
dc.subjectAntiBSA detectionen
dc.subjectBioelectronicsen
dc.subjectEncapsulation effecten
dc.subjectOTFT sensorsen
dc.subjectPH sensoren
dc.titleEffect of passivation on the sensitivity and stability of pentacene transistor sensors in aqueous mediaen
dc.typeArticleen
dc.contributor.departmentMaterials Science and Engineering Programen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalBiosensors and Bioelectronicsen
dc.contributor.institutionMax-Planck-Institut for Polymerforschung, Ackermannweg 10, D-55128 Mainz, Germanyen
dc.contributor.institutionOLED Center, Department of Materials Science and Engineering, Seoul National University, Seoul, 151-744, South Koreaen
dc.contributor.institutionAustrian Institute of Technology (AIT) GmbH, Donau-City-Str. 1, 1220 Vienna, Austriaen
kaust.authorKhan, Hadayat Ullahen

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