PH-triggered micellar membrane for controlled release microchips

Handle URI:
http://hdl.handle.net/10754/561664
Title:
PH-triggered micellar membrane for controlled release microchips
Authors:
Yang, Xiaoqiang; Moosa, Basem ( 0000-0002-2350-4100 ) ; Deng, Lin ( 0000-0001-8954-5610 ) ; Zhao, L. J.; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
A pH-responsive membrane based on polystyrene-b-poly(4-vinylpyridine) (PS-b-P4VP) block copolymer was developed on a model glass microchip as a promising controlled polymer delivery system. The PS-b-P4VP copolymer assembles into spherical and/or worm-like micelles with styrene block cores and pyridine coronas in selective solvents. The self-assembled worm-like morphology exhibited pH-responsive behaviour due to the protonation of the P4VP block at low pH and it's deprotonation at high pH and thus constituting a switchable "off/on" system. Doxorubicin (Dox) was used as cargo to test the PS-b-P4VP membrane. Luminescence experiments indicated that the membrane was able to store Dox molecules within its micellar structure at neutral pH and then release them as soon as the pH was raised to 8.0. The performance of the cast membrane was predictable and most importantly reproducible. The physiochemical and biological properties were also investigated carefully in terms of morphology, cell viability and cell uptake. This journal is © The Royal Society of Chemistry.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab; Advanced Nanofabrication, Imaging and Characterization Core Lab; Physical Sciences and Engineering (PSE) Division; Chemical Science Program
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Polymer Chemistry
Issue Date:
2011
DOI:
10.1039/c1py00300c
Type:
Article
ISSN:
17599954
Sponsors:
The research presented is fully sponsored by King Abdullah University of Science and Technology (KAUST). The authors thank his excellency minister Ali Ibrahim Al Naimi for his constant support to the research environment at KAUST.
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Advanced Nanofabrication, Imaging and Characterization Core Lab; Physical Sciences and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.authorYang, Xiaoqiangen
dc.contributor.authorMoosa, Basemen
dc.contributor.authorDeng, Linen
dc.contributor.authorZhao, L. J.en
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2015-08-03T09:01:48Zen
dc.date.available2015-08-03T09:01:48Zen
dc.date.issued2011en
dc.identifier.issn17599954en
dc.identifier.doi10.1039/c1py00300cen
dc.identifier.urihttp://hdl.handle.net/10754/561664en
dc.description.abstractA pH-responsive membrane based on polystyrene-b-poly(4-vinylpyridine) (PS-b-P4VP) block copolymer was developed on a model glass microchip as a promising controlled polymer delivery system. The PS-b-P4VP copolymer assembles into spherical and/or worm-like micelles with styrene block cores and pyridine coronas in selective solvents. The self-assembled worm-like morphology exhibited pH-responsive behaviour due to the protonation of the P4VP block at low pH and it's deprotonation at high pH and thus constituting a switchable "off/on" system. Doxorubicin (Dox) was used as cargo to test the PS-b-P4VP membrane. Luminescence experiments indicated that the membrane was able to store Dox molecules within its micellar structure at neutral pH and then release them as soon as the pH was raised to 8.0. The performance of the cast membrane was predictable and most importantly reproducible. The physiochemical and biological properties were also investigated carefully in terms of morphology, cell viability and cell uptake. This journal is © The Royal Society of Chemistry.en
dc.description.sponsorshipThe research presented is fully sponsored by King Abdullah University of Science and Technology (KAUST). The authors thank his excellency minister Ali Ibrahim Al Naimi for his constant support to the research environment at KAUST.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titlePH-triggered micellar membrane for controlled release microchipsen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Laben
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.identifier.journalPolymer Chemistryen
kaust.authorYang, Xiaoqiangen
kaust.authorMoosa, Basemen
kaust.authorDeng, Linen
kaust.authorKhashab, Niveen M.en
kaust.authorZhao, L. J.en
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