Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines

Handle URI:
http://hdl.handle.net/10754/561648
Title:
Guanidine-catalyzed enantioselective desymmetrization of meso-aziridines
Authors:
Zhang, Yan; Kee, Choonwee; Lee, Richmond; Fu, Xiao; Soh, J. Y T; Loh, E. M F; Huang, Kuo-Wei ( 0000-0003-1900-2658 ) ; Tan, Choonhong
Abstract:
An amino-indanol derived chiral guanidine was developed as an efficient Brønsted base catalyst for the desymmetrization of meso-aziridines with both thiols and carbamodithioic acids as nucleophiles, which provided 1,2-difunctionalized ring-opened products in high yields and enantioselectivities. © The Royal Society of Chemistry.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; KAUST Catalysis Center (KCC); Chemical Science Program; Physical Sciences and Engineering (PSE) Division; HCL
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Chemical Communications
Issue Date:
2011
DOI:
10.1039/c0cc05840h
PubMed ID:
21336394
Type:
Article
ISSN:
13597345
Is Supplemented By:
Zhang, Y., Kee, C. W., Lee, R., Fu, X., Soh, J. Y.-T., Loh, E. M. F., … Tan, C.-H. (2011). CCDC 806368: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccw22ww; DOI:10.5517/ccw22ww; HANDLE:http://hdl.handle.net/10754/624627; Zhang, Y., Kee, C. W., Lee, R., Fu, X., Soh, J. Y.-T., Loh, E. M. F., … Tan, C.-H. (2011). CCDC 806369: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccw22xx; DOI:10.5517/ccw22xx; HANDLE:http://hdl.handle.net/10754/624628
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; KAUST Catalysis Center (KCC); Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorZhang, Yanen
dc.contributor.authorKee, Choonweeen
dc.contributor.authorLee, Richmonden
dc.contributor.authorFu, Xiaoen
dc.contributor.authorSoh, J. Y Ten
dc.contributor.authorLoh, E. M Fen
dc.contributor.authorHuang, Kuo-Weien
dc.contributor.authorTan, Choonhongen
dc.date.accessioned2015-08-03T09:01:20Zen
dc.date.available2015-08-03T09:01:20Zen
dc.date.issued2011en
dc.identifier.issn13597345en
dc.identifier.pmid21336394en
dc.identifier.doi10.1039/c0cc05840hen
dc.identifier.urihttp://hdl.handle.net/10754/561648en
dc.description.abstractAn amino-indanol derived chiral guanidine was developed as an efficient Brønsted base catalyst for the desymmetrization of meso-aziridines with both thiols and carbamodithioic acids as nucleophiles, which provided 1,2-difunctionalized ring-opened products in high yields and enantioselectivities. © The Royal Society of Chemistry.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleGuanidine-catalyzed enantioselective desymmetrization of meso-aziridinesen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentKAUST Catalysis Center (KCC)en
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentHCLen
dc.identifier.journalChemical Communicationsen
dc.contributor.institutionDepartment of Chemistry, National University of Singapore (NUS), 3 Science Drive 3, 117543 Singapore, Singaporeen
kaust.authorLee, Richmonden
kaust.authorHuang, Kuo-Weien
dc.relation.isSupplementedByZhang, Y., Kee, C. W., Lee, R., Fu, X., Soh, J. Y.-T., Loh, E. M. F., … Tan, C.-H. (2011). CCDC 806368: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccw22wwen
dc.relation.isSupplementedByDOI:10.5517/ccw22wwen
dc.relation.isSupplementedByHANDLE:http://hdl.handle.net/10754/624627en
dc.relation.isSupplementedByZhang, Y., Kee, C. W., Lee, R., Fu, X., Soh, J. Y.-T., Loh, E. M. F., … Tan, C.-H. (2011). CCDC 806369: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccw22xxen
dc.relation.isSupplementedByDOI:10.5517/ccw22xxen
dc.relation.isSupplementedByHANDLE:http://hdl.handle.net/10754/624628en

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