Developmental transcriptome of Aplysia californica'

Handle URI:
http://hdl.handle.net/10754/561640
Title:
Developmental transcriptome of Aplysia californica'
Authors:
Heyland, Andreas; Vue, Zer; Voolstra, Christian R. ( 0000-0003-4555-3795 ) ; Medina, Mónica; Moroz, Leonid L.
Abstract:
Genome-wide transcriptional changes in development provide important insight into mechanisms underlying growth, differentiation, and patterning. However, such large-scale developmental studies have been limited to a few representatives of Ecdysozoans and Chordates. Here, we characterize transcriptomes of embryonic, larval, and metamorphic development in the marine mollusc Aplysia californica and reveal novel molecular components associated with life history transitions. Specifically, we identify more than 20 signal peptides, putative hormones, and transcription factors in association with early development and metamorphic stages-many of which seem to be evolutionarily conserved elements of signal transduction pathways. We also characterize genes related to biomineralization-a critical process of molluscan development. In summary, our experiment provides the first large-scale survey of gene expression in mollusc development, and complements previous studies on the regulatory mechanisms underlying body plan patterning and the formation of larval and juvenile structures. This study serves as a resource for further functional annotation of transcripts and genes in Aplysia, specifically and molluscs in general. A comparison of the Aplysia developmental transcriptome with similar studies in the zebra fish Danio rerio, the fruit fly Drosophila melanogaster, the nematode Caenorhabditis elegans, and other studies on molluscs suggests an overall highly divergent pattern of gene regulatory mechanisms that are likely a consequence of the different developmental modes of these organisms. © 2010 Wiley-Liss, Inc., A Wiley Company.
KAUST Department:
Red Sea Research Center (RSRC); Biological and Environmental Sciences and Engineering (BESE) Division; Marine Science Program; Reef Genomics Lab
Publisher:
Wiley
Journal:
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution
Issue Date:
6-Dec-2010
DOI:
10.1002/jez.b.21383
PubMed ID:
21328528
PubMed Central ID:
PMC4028319
Type:
Article
ISSN:
15525007
Sponsors:
Grant Sponsors: Swiss National Science Foundation Stipendium fuer Angehende Forscher, Brain Research Foundation; NSERC; Grant number: C400230; Grant Sponsor: CFI; Grant number: 460175; Grant Sponsor: NIH; Grant numbers: P50HG002806; R01NS06076; RR025699; Grant Sponsor: NSF; Grant numbers: 0744649; DEB-0542330.
Additional Links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028319
Appears in Collections:
Articles; Red Sea Research Center (RSRC); Marine Science Program; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorHeyland, Andreasen
dc.contributor.authorVue, Zeren
dc.contributor.authorVoolstra, Christian R.en
dc.contributor.authorMedina, Mónicaen
dc.contributor.authorMoroz, Leonid L.en
dc.date.accessioned2015-08-03T09:01:07Zen
dc.date.available2015-08-03T09:01:07Zen
dc.date.issued2010-12-06en
dc.identifier.issn15525007en
dc.identifier.pmid21328528en
dc.identifier.doi10.1002/jez.b.21383en
dc.identifier.urihttp://hdl.handle.net/10754/561640en
dc.description.abstractGenome-wide transcriptional changes in development provide important insight into mechanisms underlying growth, differentiation, and patterning. However, such large-scale developmental studies have been limited to a few representatives of Ecdysozoans and Chordates. Here, we characterize transcriptomes of embryonic, larval, and metamorphic development in the marine mollusc Aplysia californica and reveal novel molecular components associated with life history transitions. Specifically, we identify more than 20 signal peptides, putative hormones, and transcription factors in association with early development and metamorphic stages-many of which seem to be evolutionarily conserved elements of signal transduction pathways. We also characterize genes related to biomineralization-a critical process of molluscan development. In summary, our experiment provides the first large-scale survey of gene expression in mollusc development, and complements previous studies on the regulatory mechanisms underlying body plan patterning and the formation of larval and juvenile structures. This study serves as a resource for further functional annotation of transcripts and genes in Aplysia, specifically and molluscs in general. A comparison of the Aplysia developmental transcriptome with similar studies in the zebra fish Danio rerio, the fruit fly Drosophila melanogaster, the nematode Caenorhabditis elegans, and other studies on molluscs suggests an overall highly divergent pattern of gene regulatory mechanisms that are likely a consequence of the different developmental modes of these organisms. © 2010 Wiley-Liss, Inc., A Wiley Company.en
dc.description.sponsorshipGrant Sponsors: Swiss National Science Foundation Stipendium fuer Angehende Forscher, Brain Research Foundation; NSERC; Grant number: C400230; Grant Sponsor: CFI; Grant number: 460175; Grant Sponsor: NIH; Grant numbers: P50HG002806; R01NS06076; RR025699; Grant Sponsor: NSF; Grant numbers: 0744649; DEB-0542330.en
dc.publisherWileyen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028319en
dc.titleDevelopmental transcriptome of Aplysia californica'en
dc.typeArticleen
dc.contributor.departmentRed Sea Research Center (RSRC)en
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentMarine Science Programen
dc.contributor.departmentReef Genomics Laben
dc.identifier.journalJournal of Experimental Zoology Part B: Molecular and Developmental Evolutionen
dc.identifier.pmcidPMC4028319en
dc.contributor.institutionIntegrative Biology, University of Guelph, ON, Canadaen
dc.contributor.institutionUniversity of California, School of Natural Sciences, Merced, CA, United Statesen
dc.contributor.institutionThe Whitney Laboratory for Marine Bioscience, University of Florida, FL, United Statesen
dc.contributor.institutionDepartment of Neuroscience, University of Florida, FL, United Statesen
kaust.authorVoolstra, Christian R.en

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