RNA-directed DNA methylation: Mechanisms and functions

Handle URI:
http://hdl.handle.net/10754/561530
Title:
RNA-directed DNA methylation: Mechanisms and functions
Authors:
Mahfouz, Magdy M. ( 0000-0002-0616-6365 )
Abstract:
Epigenetic RNA based gene silencing mechanisms play a major role in genome stability and control of gene expression. Transcriptional gene silencing via RNA-directed DNA methylation (RdDM) guides the epigenetic regulation of the genome in response to disease states, growth, developmental and stress signals. RdDM machinery is composed of proteins that produce and modify 24-nt- long siRNAs, recruit the RdDM complex to genomic targets, methylate DNA and remodel chromatin. The final DNA methylation pattern is determined by either DNA methyltransferase alone or by the combined action of DNA methyltransferases and demethylases. The dynamic interaction between RdDM and demethylases may render the plant epigenome plastic to growth, developmental, and environmental cues. The epigenome plasticity may allow the plant genome to assume many epigenomes and to have the right epigenome at the right time in response to intracellular or extracellular stimuli. This review discusses recent advances in RdDM research and considers future perspectives.
KAUST Department:
Center for Desert Agriculture; Bioscience Program; Biological and Environmental Sciences and Engineering (BESE) Division
Publisher:
Informa UK Limited
Journal:
Plant Signaling & Behavior
Issue Date:
Jul-2010
DOI:
10.4161/psb.5.7.11695
PubMed ID:
20421728
PubMed Central ID:
PMC3115029
Type:
Article
ISSN:
15592316
Additional Links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115029
Appears in Collections:
Articles; Bioscience Program; Center for Desert Agriculture; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorMahfouz, Magdy M.en
dc.date.accessioned2015-08-02T09:13:34Zen
dc.date.available2015-08-02T09:13:34Zen
dc.date.issued2010-07en
dc.identifier.issn15592316en
dc.identifier.pmid20421728en
dc.identifier.doi10.4161/psb.5.7.11695en
dc.identifier.urihttp://hdl.handle.net/10754/561530en
dc.description.abstractEpigenetic RNA based gene silencing mechanisms play a major role in genome stability and control of gene expression. Transcriptional gene silencing via RNA-directed DNA methylation (RdDM) guides the epigenetic regulation of the genome in response to disease states, growth, developmental and stress signals. RdDM machinery is composed of proteins that produce and modify 24-nt- long siRNAs, recruit the RdDM complex to genomic targets, methylate DNA and remodel chromatin. The final DNA methylation pattern is determined by either DNA methyltransferase alone or by the combined action of DNA methyltransferases and demethylases. The dynamic interaction between RdDM and demethylases may render the plant epigenome plastic to growth, developmental, and environmental cues. The epigenome plasticity may allow the plant genome to assume many epigenomes and to have the right epigenome at the right time in response to intracellular or extracellular stimuli. This review discusses recent advances in RdDM research and considers future perspectives.en
dc.publisherInforma UK Limiteden
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115029en
dc.titleRNA-directed DNA methylation: Mechanisms and functionsen
dc.typeArticleen
dc.contributor.departmentCenter for Desert Agricultureen
dc.contributor.departmentBioscience Programen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalPlant Signaling & Behavioren
dc.identifier.pmcidPMC3115029en
dc.contributor.institutionAgricultural Genetic Engineering research institute (AGERI), Agricultural research Center, Giza, Egypten
kaust.authorMahfouz, Magdy M.en

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