Snap-top nanocarriers

Handle URI:
http://hdl.handle.net/10754/561502
Title:
Snap-top nanocarriers
Authors:
Ambrogio, Michael W.; Pecorelli, Travis A.; Patel, Kaushik I.; Khashab, Niveen M. ( 0000-0003-2728-0666 ) ; Trabolsi, Ali; Khatib, Hussam A.; Botros, Youssry Y.; Zink, Jeffrey I.; Stoddart, Fraser Fraser Raser
Abstract:
(Equation Presented). An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks,-which are encircled by cucurbit[6]uril or α-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles. © 2010 American Chemical Society.
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab
Publisher:
American Chemical Society
Journal:
Organic Letters
Issue Date:
6-Aug-2010
DOI:
10.1021/ol101286a
PubMed ID:
20608669
Type:
Article
ISSN:
15237060
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.authorAmbrogio, Michael W.en
dc.contributor.authorPecorelli, Travis A.en
dc.contributor.authorPatel, Kaushik I.en
dc.contributor.authorKhashab, Niveen M.en
dc.contributor.authorTrabolsi, Alien
dc.contributor.authorKhatib, Hussam A.en
dc.contributor.authorBotros, Youssry Y.en
dc.contributor.authorZink, Jeffrey I.en
dc.contributor.authorStoddart, Fraser Fraser Raseren
dc.date.accessioned2015-08-02T09:12:56Zen
dc.date.available2015-08-02T09:12:56Zen
dc.date.issued2010-08-06en
dc.identifier.issn15237060en
dc.identifier.pmid20608669en
dc.identifier.doi10.1021/ol101286aen
dc.identifier.urihttp://hdl.handle.net/10754/561502en
dc.description.abstract(Equation Presented). An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks,-which are encircled by cucurbit[6]uril or α-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles. © 2010 American Chemical Society.en
dc.publisherAmerican Chemical Societyen
dc.titleSnap-top nanocarriersen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.identifier.journalOrganic Lettersen
dc.contributor.institutionDepartment of Chemistry, Materials Science and Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113, United Statesen
dc.contributor.institutionDepartment of Chemistry and Biochemistry, California NanoSystems Institute, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095-1569, United Statesen
dc.contributor.institutionIntel Labs, Building RNB-6-61, 2200 Mission College Blvd., Santa Clara, CA 95054-1549, United Statesen
dc.contributor.institutionNational Center for Nano Technology Research, King Abdulaziz City for Science and Technology (KACST), P.O. BOX 6086, Riyadh 11442, Saudi Arabiaen
kaust.authorKhashab, Niveen M.en

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