Gibberellic acid and cGMP-dependent transcriptional regulation in arabidopsis thaliana

Handle URI:
http://hdl.handle.net/10754/561498
Title:
Gibberellic acid and cGMP-dependent transcriptional regulation in arabidopsis thaliana
Authors:
Bastian, René; Dawe, Adam Sean; Meier, Stuart Kurt; Ludidi, Ndiko N.; Bajic, Vladimir B. ( 0000-0001-5435-4750 ) ; Gehring, Christoph A. ( 0000-0003-4355-4591 )
Abstract:
An ever increasing amount of transcriptomic data and analysis tools provide novel insight into complex responses of biological systems. Given these resources we have undertaken to review aspects of transcriptional regulation in response to the plant hormone gibberellic acid (GA) and its second messenger guanosine 3',5'-cyclic monophosphate (cGMP) in Arabidopsis thaliana, both wild type and selected mutants. Evidence suggests enrichment of GA-responsive (GARE) elements in promoters of genes that are transcriptionally upregulated in response to cGMP but downregulated in a GA insensitive mutant (ga1-3). In contrast, in the genes upregulated in the mutant, no enrichment in the GARE is observed suggesting that GARE motifs are diagnostic for GA-induced and cGMP-dependent transcriptional upregulation. Further, we review how expression studies of GA-dependent transcription factors and transcriptional networks based on common promoter signatures derived from ab initio analyses can contribute to our understanding of plant responses at the systems level. © 2010 Landes Bioscience.
KAUST Department:
Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Applied Mathematics and Computational Science Program; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Molecular Signalling Group
Publisher:
Taylor & Francis
Journal:
Plant Signaling and Behavior
Issue Date:
Mar-2010
DOI:
10.4161/psb.5.3.10718
PubMed ID:
20118660
Type:
Article
ISSN:
15592316
Appears in Collections:
Articles; Bioscience Program; Applied Mathematics and Computational Science Program; Computational Bioscience Research Center (CBRC); Biological and Environmental Sciences and Engineering (BESE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorBastian, Renéen
dc.contributor.authorDawe, Adam Seanen
dc.contributor.authorMeier, Stuart Kurten
dc.contributor.authorLudidi, Ndiko N.en
dc.contributor.authorBajic, Vladimir B.en
dc.contributor.authorGehring, Christoph A.en
dc.date.accessioned2015-08-02T09:12:50Zen
dc.date.available2015-08-02T09:12:50Zen
dc.date.issued2010-03en
dc.identifier.issn15592316en
dc.identifier.pmid20118660en
dc.identifier.doi10.4161/psb.5.3.10718en
dc.identifier.urihttp://hdl.handle.net/10754/561498en
dc.description.abstractAn ever increasing amount of transcriptomic data and analysis tools provide novel insight into complex responses of biological systems. Given these resources we have undertaken to review aspects of transcriptional regulation in response to the plant hormone gibberellic acid (GA) and its second messenger guanosine 3',5'-cyclic monophosphate (cGMP) in Arabidopsis thaliana, both wild type and selected mutants. Evidence suggests enrichment of GA-responsive (GARE) elements in promoters of genes that are transcriptionally upregulated in response to cGMP but downregulated in a GA insensitive mutant (ga1-3). In contrast, in the genes upregulated in the mutant, no enrichment in the GARE is observed suggesting that GARE motifs are diagnostic for GA-induced and cGMP-dependent transcriptional upregulation. Further, we review how expression studies of GA-dependent transcription factors and transcriptional networks based on common promoter signatures derived from ab initio analyses can contribute to our understanding of plant responses at the systems level. © 2010 Landes Bioscience.en
dc.publisherTaylor & Francisen
dc.subject5'-cyclic monophosphate (cGMP)en
dc.subjectGibberellic aciden
dc.subjectGibberellic acid response elements (GARE)en
dc.subjectGuanosine 3'en
dc.subjectPlant homeostasisen
dc.titleGibberellic acid and cGMP-dependent transcriptional regulation in arabidopsis thalianaen
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentApplied Mathematics and Computational Science Programen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentBioscience Programen
dc.contributor.departmentMolecular Signalling Groupen
dc.identifier.journalPlant Signaling and Behavioren
dc.contributor.institutionDepartment of Biotechnology, University of the Western Cape, Bellville, South Africaen
dc.contributor.institutionInstitute for Plant Biotechnology, Stellenbosch University, Matieland, South Africaen
kaust.authorDawe, Adam Seanen
kaust.authorMeier, Stuart Kurten
kaust.authorBajic, Vladimir B.en
kaust.authorGehring, Christoph A.en

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