A constitutive model of soft tissue: From nanoscale collagen to tissue continuum

Handle URI:
http://hdl.handle.net/10754/561415
Title:
A constitutive model of soft tissue: From nanoscale collagen to tissue continuum
Authors:
Tang, Huang; Buehler, Markus J.; Moran, Brian ( 0000-0002-6875-8630 )
Abstract:
Soft collagenous tissue features many hierarchies of structure, starting from tropocollagen molecules that form fibrils, and proceeding to a bundle of fibrils that form fibers. Here we report the development of an atomistically informed continuum model of collagenous tissue. Results from full atomistic and molecular modeling are linked with a continuum theory of a fiber-reinforced composite, handshaking the fibril scale to the fiber and continuum scale in a hierarchical multi-scale simulation approach. Our model enables us to study the continuum-level response of the tissue as a function of cross-link density, making a link between nanoscale collagen features and material properties at larger tissue scales. The results illustrate a strong dependence of the continuum response as a function of nanoscopic structural features, providing evidence for the notion that the molecular basis for protein materials is important in defining their larger-scale mechanical properties. © 2009 Biomedical Engineering Society.
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Mechanical Engineering Program
Publisher:
Springer Verlag
Journal:
Annals of Biomedical Engineering
Issue Date:
8-Apr-2009
DOI:
10.1007/s10439-009-9679-0
Type:
Article
ISSN:
00906964
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Mechanical Engineering Program

Full metadata record

DC FieldValue Language
dc.contributor.authorTang, Huangen
dc.contributor.authorBuehler, Markus J.en
dc.contributor.authorMoran, Brianen
dc.date.accessioned2015-08-02T09:10:38Zen
dc.date.available2015-08-02T09:10:38Zen
dc.date.issued2009-04-08en
dc.identifier.issn00906964en
dc.identifier.doi10.1007/s10439-009-9679-0en
dc.identifier.urihttp://hdl.handle.net/10754/561415en
dc.description.abstractSoft collagenous tissue features many hierarchies of structure, starting from tropocollagen molecules that form fibrils, and proceeding to a bundle of fibrils that form fibers. Here we report the development of an atomistically informed continuum model of collagenous tissue. Results from full atomistic and molecular modeling are linked with a continuum theory of a fiber-reinforced composite, handshaking the fibril scale to the fiber and continuum scale in a hierarchical multi-scale simulation approach. Our model enables us to study the continuum-level response of the tissue as a function of cross-link density, making a link between nanoscale collagen features and material properties at larger tissue scales. The results illustrate a strong dependence of the continuum response as a function of nanoscopic structural features, providing evidence for the notion that the molecular basis for protein materials is important in defining their larger-scale mechanical properties. © 2009 Biomedical Engineering Society.en
dc.publisherSpringer Verlagen
dc.subjectCollagenen
dc.subjectContinuumen
dc.subjectDeformationen
dc.subjectFailureen
dc.subjectFinite elementen
dc.subjectMechanical propertiesen
dc.subjectMolecular mechanicsen
dc.subjectMulti-scale modelen
dc.subjectSoft tissueen
dc.titleA constitutive model of soft tissue: From nanoscale collagen to tissue continuumen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentMechanical Engineering Programen
dc.identifier.journalAnnals of Biomedical Engineeringen
dc.contributor.institutionDepartment of Civil and Environmental Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3109, United Statesen
dc.contributor.institutionLaboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA, United Statesen
kaust.authorMoran, Brianen
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