A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve

Handle URI:
http://hdl.handle.net/10754/561187
Title:
A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve
Authors:
Yi, Ying; Zaher, Amir ( 0000-0002-5521-5389 ) ; Yassine, Omar ( 0000-0002-0117-8017 ) ; Kosel, Jürgen ( 0000-0002-8998-8275 ) ; Foulds, Ian G.
Abstract:
Implantable drug delivery devices are becoming attractive due to their abilities of targeted and controlled dose release. Currently, two important issues are functional lifetime and non-controlled drug diffusion. In this work, we present a drug delivery device combining an electrolytic pump and a thermo-responsive valve, which are both remotely controlled by an electromagnetic field (40.5 mT and 450 kHz). Our proposed device exhibits a novel operation mechanism for long-term therapeutic treatments using a solid drug in reservoir approach. Our device also prevents undesired drug liquid diffusions. When the electromagnetic field is on, the electrolysis-induced bubble drives the drug liquid towards the Poly (N-Isopropylacrylamide) (PNIPAM) valve that consists of PNIPAM and iron micro-particles. The heat generated by the iron micro-particles causes the PNIPAM to shrink, resulting in an open valve. When the electromagnetic field is turned off, the PNIPAM starts to swell. In the meantime, the bubbles are catalytically recombined into water, reducing the pressure inside the pumping chamber, which leads to the refilling of the fresh liquid from outside the device. A catalytic reformer is included, allowing more liquid refilling during the limited valve's closing time. The amount of body liquid that refills the drug reservoir can further dissolve the solid drug, forming a reproducible drug solution for the next dose. By repeatedly turning on and off the electromagnetic field, the drug dose can be cyclically released, and the exit port of the device is effectively controlled.
KAUST Department:
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Citation:
A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve 2015, 9 (5):052608 Biomicrofluidics
Publisher:
AIP Publishing
Journal:
Biomicrofluidics
Issue Date:
22-Jul-2015
DOI:
10.1063/1.4927436
Type:
Article
ISSN:
1932-1058
Additional Links:
http://scitation.aip.org/content/aip/journal/bmf/9/5/10.1063/1.4927436
Appears in Collections:
Articles; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorYi, Yingen
dc.contributor.authorZaher, Amiren
dc.contributor.authorYassine, Omaren
dc.contributor.authorKosel, Jürgenen
dc.contributor.authorFoulds, Ian G.en
dc.date.accessioned2015-07-28T13:04:35Zen
dc.date.available2015-07-28T13:04:35Zen
dc.date.issued2015-07-22en
dc.identifier.citationA remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve 2015, 9 (5):052608 Biomicrofluidicsen
dc.identifier.issn1932-1058en
dc.identifier.doi10.1063/1.4927436en
dc.identifier.urihttp://hdl.handle.net/10754/561187en
dc.description.abstractImplantable drug delivery devices are becoming attractive due to their abilities of targeted and controlled dose release. Currently, two important issues are functional lifetime and non-controlled drug diffusion. In this work, we present a drug delivery device combining an electrolytic pump and a thermo-responsive valve, which are both remotely controlled by an electromagnetic field (40.5 mT and 450 kHz). Our proposed device exhibits a novel operation mechanism for long-term therapeutic treatments using a solid drug in reservoir approach. Our device also prevents undesired drug liquid diffusions. When the electromagnetic field is on, the electrolysis-induced bubble drives the drug liquid towards the Poly (N-Isopropylacrylamide) (PNIPAM) valve that consists of PNIPAM and iron micro-particles. The heat generated by the iron micro-particles causes the PNIPAM to shrink, resulting in an open valve. When the electromagnetic field is turned off, the PNIPAM starts to swell. In the meantime, the bubbles are catalytically recombined into water, reducing the pressure inside the pumping chamber, which leads to the refilling of the fresh liquid from outside the device. A catalytic reformer is included, allowing more liquid refilling during the limited valve's closing time. The amount of body liquid that refills the drug reservoir can further dissolve the solid drug, forming a reproducible drug solution for the next dose. By repeatedly turning on and off the electromagnetic field, the drug dose can be cyclically released, and the exit port of the device is effectively controlled.en
dc.publisherAIP Publishingen
dc.relation.urlhttp://scitation.aip.org/content/aip/journal/bmf/9/5/10.1063/1.4927436en
dc.rightsArchived with thanks to Biomicrofluidicsen
dc.titleA remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valveen
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.identifier.journalBiomicrofluidicsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionSchool of Engineering, University of British Columbia (UBC), Kelowna, British Columbia V1V 1V7, Canadaen
dc.contributor.institutionSchool of Engineering, University of British Columbia (UBC), Kelowna, British Columbia V1V 1V7, Canadaen
dc.contributor.institutionSchool of Engineering, University of British Columbia (UBC), Kelowna, British Columbia V1V 1V7, Canadaen
kaust.authorYassine, Omaren
kaust.authorKosel, Jürgenen
kaust.authorFoulds, Ian G.en
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