Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging

Handle URI:
http://hdl.handle.net/10754/558874
Title:
Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging
Authors:
Fatieiev, Yevhen ( 0000-0002-2844-8427 ) ; Croissant, Jonas G.; Julfakyan, Khachatur ( 0000-0003-2482-0911 ) ; Deng, Lin ( 0000-0001-8954-5610 ) ; Anjum, Dalaver H.; Gurinov, Andrei; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Non-aggregated dense bridged silsesquioxane (BS) nanoparticles based on nature-inspired oxamide bridges are shown to degrade in simulated biological media upon cleavage with endopeptidase. Fluorescent BS nanoprobes with incorporated fluorescein dyes were applied for in-vitro imaging in cancer cells.
KAUST Department:
Smart Hybrid Materials (SHMs) lab; Advanced Membranes and Porous Materials Research Center; Advanced Nanofabrication and Thin Film Core Lab; Imaging and Characterization Core Lab
Citation:
Enzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging 2015 Nanoscale
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Nanoscale
Issue Date:
30-Jun-2015
DOI:
10.1039/C5NR03065J
Type:
Article
ISSN:
2040-3364; 2040-3372
Additional Links:
http://pubs.rsc.org/en/Content/ArticleLanding/2015/NR/C5NR03065J
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Advanced Nanofabrication, Imaging and Characterization Core Lab; Controlled Release and Delivery Laboratory

Full metadata record

DC FieldValue Language
dc.contributor.authorFatieiev, Yevhenen
dc.contributor.authorCroissant, Jonas G.en
dc.contributor.authorJulfakyan, Khachaturen
dc.contributor.authorDeng, Linen
dc.contributor.authorAnjum, Dalaver H.en
dc.contributor.authorGurinov, Andreien
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2015-07-05T12:28:16Zen
dc.date.available2015-07-05T12:28:16Zen
dc.date.issued2015-06-30en
dc.identifier.citationEnzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imaging 2015 Nanoscaleen
dc.identifier.issn2040-3364en
dc.identifier.issn2040-3372en
dc.identifier.doi10.1039/C5NR03065Jen
dc.identifier.urihttp://hdl.handle.net/10754/558874en
dc.description.abstractNon-aggregated dense bridged silsesquioxane (BS) nanoparticles based on nature-inspired oxamide bridges are shown to degrade in simulated biological media upon cleavage with endopeptidase. Fluorescent BS nanoprobes with incorporated fluorescein dyes were applied for in-vitro imaging in cancer cells.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.relation.urlhttp://pubs.rsc.org/en/Content/ArticleLanding/2015/NR/C5NR03065Jen
dc.rightsArchived with thanks to Nanoscaleen
dc.titleEnzymatically Degradable Hybrid Organic-Inorganic Bridged Silsesquioxane Nanoparticles for In-Vitro Imagingen
dc.typeArticleen
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentAdvanced Nanofabrication and Thin Film Core Laben
dc.contributor.departmentImaging and Characterization Core Laben
dc.identifier.journalNanoscaleen
dc.eprint.versionPost-printen
kaust.authorCroissant, Jonas G.en
kaust.authorAnjum, Dalaver H.en
kaust.authorKhashab, Niveen M.en
kaust.authorFatieiev, Yevhenen
kaust.authorJulfakyan, Khachaturen
kaust.authorDeng, L.en
kaust.authorGurinov, Andreien
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