Wound repair during arm regeneration in the red starfish Echinaster sepositus

Handle URI:
http://hdl.handle.net/10754/558700
Title:
Wound repair during arm regeneration in the red starfish Echinaster sepositus
Authors:
Ben Khadra, Yousra; Ferrario, Cinzia; Di Benedetto, Cristiano; Said, Khaled; Bonasoro, Francesco; Candia Carnevali, M. Daniela; Sugni, Michela
Abstract:
Starfish can regenerate entire arms following their loss by both autotomic and traumatic amputation. Although the overall regenerative process has been studied several times in different asteroid species, there is still a considerable gap of knowledge as far as the detailed aspects of the repair phase at tissue and cellular level are concerned, particularly in post-traumatic regeneration. The present work is focused on the arm regeneration model in the Mediterranean red starfish Echinaster sepositus; in order to describe the early cellular mechanisms of arm regeneration following traumatic amputation, different microscopy techniques were employed. In E. sepositus, the repair phase was characterized by prompt wound healing by a syncytial network of phagocytes and re-epithelialisation followed by a localized subepidermal oedematous area formation. Scattered and apparently undifferentiated cells, intermixed with numerous phagocytes, were frequently found in the wound area during these first stages of regeneration and extensive dedifferentiation phenomena were seen at the level of the stump, particularly in the muscle bundles. A true localized blastema did not form. Our results confirm that regeneration in asteroids mainly relies on morphallactic processes, consisting in extensive rearrangement of the existing tissues which contribute to the new tissues through cell dedifferentiation, re-differentiation and/or migration. This article is protected by copyright. All rights reserved.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Wound repair during arm regeneration in the red starfish Echinaster sepositus 2015:n/a Wound Repair and Regeneration
Publisher:
Wiley-Blackwell
Journal:
Wound Repair and Regeneration
Issue Date:
24-Jun-2015
DOI:
10.1111/wrr.12333
Type:
Article
ISSN:
10671927
Additional Links:
http://doi.wiley.com/10.1111/wrr.12333
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorBen Khadra, Yousraen
dc.contributor.authorFerrario, Cinziaen
dc.contributor.authorDi Benedetto, Cristianoen
dc.contributor.authorSaid, Khaleden
dc.contributor.authorBonasoro, Francescoen
dc.contributor.authorCandia Carnevali, M. Danielaen
dc.contributor.authorSugni, Michelaen
dc.date.accessioned2015-06-30T14:16:12Zen
dc.date.available2015-06-30T14:16:12Zen
dc.date.issued2015-06-24en
dc.identifier.citationWound repair during arm regeneration in the red starfish Echinaster sepositus 2015:n/a Wound Repair and Regenerationen
dc.identifier.issn10671927en
dc.identifier.doi10.1111/wrr.12333en
dc.identifier.urihttp://hdl.handle.net/10754/558700en
dc.description.abstractStarfish can regenerate entire arms following their loss by both autotomic and traumatic amputation. Although the overall regenerative process has been studied several times in different asteroid species, there is still a considerable gap of knowledge as far as the detailed aspects of the repair phase at tissue and cellular level are concerned, particularly in post-traumatic regeneration. The present work is focused on the arm regeneration model in the Mediterranean red starfish Echinaster sepositus; in order to describe the early cellular mechanisms of arm regeneration following traumatic amputation, different microscopy techniques were employed. In E. sepositus, the repair phase was characterized by prompt wound healing by a syncytial network of phagocytes and re-epithelialisation followed by a localized subepidermal oedematous area formation. Scattered and apparently undifferentiated cells, intermixed with numerous phagocytes, were frequently found in the wound area during these first stages of regeneration and extensive dedifferentiation phenomena were seen at the level of the stump, particularly in the muscle bundles. A true localized blastema did not form. Our results confirm that regeneration in asteroids mainly relies on morphallactic processes, consisting in extensive rearrangement of the existing tissues which contribute to the new tissues through cell dedifferentiation, re-differentiation and/or migration. This article is protected by copyright. All rights reserved.en
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://doi.wiley.com/10.1111/wrr.12333en
dc.rightsThis is the peer reviewed version of the following article: Ben Khadra, Yousra, Cinzia Ferrario, Cristiano Di Benedetto, Khaled Said, Francesco Bonasoro, M. Daniela Candia Carnevali, and Michela Sugni. "Wound repair during arm regeneration in the red starfish Echinaster sepositus." Wound Repair and Regeneration (2015)., which has been published in final form at http://doi.wiley.com/10.1111/wrr.12333. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.en
dc.subjectwound healingen
dc.subjectsubepidermal oedematous areaen
dc.subjectrepair phaseen
dc.subjectarm regenerationen
dc.subjectEchinaster sepositusen
dc.subjectmorphallaxisen
dc.titleWound repair during arm regeneration in the red starfish Echinaster sepositusen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalWound Repair and Regenerationen
dc.eprint.versionPost-printen
dc.contributor.institutionLaboratoire de Recherche, Génétique, Biodiversité et Valorisation des Bioressources, Institut Supérieur de Biotechnologie de Monastir; Université de Monastir; Monastir Tunisiaen
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italyen
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italyen
dc.contributor.institutionLaboratoire de Recherche, Génétique, Biodiversité et Valorisation des Bioressources, Institut Supérieur de Biotechnologie de Monastir; Université de Monastir; Monastir Tunisiaen
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italyen
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italyen
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italyen
kaust.authorDi Benedetto, Cristianoen
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.