Re-growth, morphogenesis and differentiation during starfish arm regeneration

Handle URI:
http://hdl.handle.net/10754/558682
Title:
Re-growth, morphogenesis and differentiation during starfish arm regeneration
Authors:
Khadra, Yousra Ben; Ferrario, Cinzia; Said, Khaled; Di Benedetto, Cristiano; Bonasoro, Francesco; Candia Carnevali, M. Daniela; Sugni, Michela
Abstract:
The red starfish Echinaster sepositus is an excellent model for studying arm regeneration processes following traumatic amputation. The initial repair phase was described in a previous paper in terms of the early cicatrisation phenomena, and tissue and cell involvement. In this work we attempt to provide a further comprehensive description of the later regenerative stages in this species. Here we present the results of a detailed microscopic and submicroscopic investigation of the long regenerative phase, which can be subdivided into two sub-phases: early and advanced regenerative phases. The early regenerative phase (1-6 weeks p.a.) is characterized by tissue rearrangement, morphogenetic processes and initial differentiation events (mainly neurogenesis and skeletogenesis). The advanced regenerative phase (after 6 weeks p.a.) is characterized by further differentiation processes (early myogenesis), and obvious morphogenesis and re-growth of the regenerate. As in other starfish, the regenerative process in E. sepositus is relatively slow in comparison with that of crinoids and many ophiuroids, which is usually interpreted as resulting mainly from size-related aspects and of the more conspicuous involvement of morphallactic processes. Light and electron microscopy analyses suggest that some of the amputated structures, such as muscles, are not able to replace their missing parts by directly regrowing them from the remaining tissues, whereas others tissues, such as the skeleton and the radial nerve cord, appear to undergo direct re-growth. The overall process is in agreement with the distalization-intercalation model proposed by Agata and co-workers (1). Further experiments are needed to confirm this hypothesis. This article is protected by copyright. All rights reserved.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Re-growth, morphogenesis and differentiation during starfish arm regeneration 2015:n/a Wound Repair and Regeneration
Journal:
Wound Repair and Regeneration
Issue Date:
25-Jun-2015
DOI:
10.1111/wrr.12336
Type:
Article
ISSN:
10671927
Additional Links:
http://doi.wiley.com/10.1111/wrr.12336
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorKhadra, Yousra Benen
dc.contributor.authorFerrario, Cinziaen
dc.contributor.authorSaid, Khaleden
dc.contributor.authorDi Benedetto, Cristianoen
dc.contributor.authorBonasoro, Francescoen
dc.contributor.authorCandia Carnevali, M. Danielaen
dc.contributor.authorSugni, Michelaen
dc.date.accessioned2015-06-30T14:31:06Zen
dc.date.available2015-06-30T14:31:06Zen
dc.date.issued2015-06-25en
dc.identifier.citationRe-growth, morphogenesis and differentiation during starfish arm regeneration 2015:n/a Wound Repair and Regenerationen
dc.identifier.issn10671927en
dc.identifier.doi10.1111/wrr.12336en
dc.identifier.urihttp://hdl.handle.net/10754/558682en
dc.description.abstractThe red starfish Echinaster sepositus is an excellent model for studying arm regeneration processes following traumatic amputation. The initial repair phase was described in a previous paper in terms of the early cicatrisation phenomena, and tissue and cell involvement. In this work we attempt to provide a further comprehensive description of the later regenerative stages in this species. Here we present the results of a detailed microscopic and submicroscopic investigation of the long regenerative phase, which can be subdivided into two sub-phases: early and advanced regenerative phases. The early regenerative phase (1-6 weeks p.a.) is characterized by tissue rearrangement, morphogenetic processes and initial differentiation events (mainly neurogenesis and skeletogenesis). The advanced regenerative phase (after 6 weeks p.a.) is characterized by further differentiation processes (early myogenesis), and obvious morphogenesis and re-growth of the regenerate. As in other starfish, the regenerative process in E. sepositus is relatively slow in comparison with that of crinoids and many ophiuroids, which is usually interpreted as resulting mainly from size-related aspects and of the more conspicuous involvement of morphallactic processes. Light and electron microscopy analyses suggest that some of the amputated structures, such as muscles, are not able to replace their missing parts by directly regrowing them from the remaining tissues, whereas others tissues, such as the skeleton and the radial nerve cord, appear to undergo direct re-growth. The overall process is in agreement with the distalization-intercalation model proposed by Agata and co-workers (1). Further experiments are needed to confirm this hypothesis. This article is protected by copyright. All rights reserved.en
dc.relation.urlhttp://doi.wiley.com/10.1111/wrr.12336en
dc.rightsThis is the peer reviewed version of the following article: Khadra, Yousra Ben, Cinzia Ferrario, Khaled Said, Cristiano Di Benedetto, Francesco Bonasoro, M. Daniela Candia Carnevali, and Michela Sugni. "Re‐growth, morphogenesis and differentiation during starfish arm regeneration." Wound Repair and Regeneration (2015)., which has been published in final form at http://doi.wiley.com/10.1111/wrr.12336. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.en
dc.subjectEchinaster sepositusen
dc.subjectoutgrowthen
dc.subjectmorphogenesisen
dc.subjectregenerative phaseen
dc.subjectArm-tip regenerationen
dc.titleRe-growth, morphogenesis and differentiation during starfish arm regenerationen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalWound Repair and Regenerationen
dc.eprint.versionPost-printen
dc.contributor.institutionLaboratoire de Recherche, Génétique, Biodiversité et Valorisation des Bioressources, Institut Supérieur de Biotechnologie de Monastir; Université de Monastir; Monastir Tunisiaen
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italyen
dc.contributor.institutionLaboratoire de Recherche, Génétique, Biodiversité et Valorisation des Bioressources, Institut Supérieur de Biotechnologie de Monastir; Université de Monastir; Monastir Tunisiaen
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italyen
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italyen
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italyen
dc.contributor.institutionDipartimento di Bioscienze; Università degli Studi di Milano; 20133 Milano Italyen
kaust.authorDi Benedetto, Cristianoen
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