How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions

Handle URI:
http://hdl.handle.net/10754/558299
Title:
How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions
Authors:
Walkiewicz, Katarzyna Wiktoria; Girault, Jean-Antoine; Arold, Stefan T. ( 0000-0001-5278-0668 )
Abstract:
The focal adhesion kinase (FAK) and the related protein-tyrosine kinase 2-beta (Pyk2) are highly versatile multidomain scaffolds central to cell adhesion, migration, and survival. Due to their key role in cancer metastasis, understanding and inhibiting their functions are important for the development of targeted therapy. Because FAK and Pyk2 are involved in many different cellular functions, designing drugs with partial and function-specific inhibitory effects would be desirable. Here, we summarise recent progress in understanding the structural mechanism of how the tug-of-war between intramolecular and intermolecular interactions allows these protein ‘nanomachines’ to become activated in a site-specific manner.
KAUST Department:
Computational Bioscience Research Center (CBRC); Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions 2015 Progress in Biophysics and Molecular Biology
Publisher:
Elsevier BV
Journal:
Progress in Biophysics and Molecular Biology
Issue Date:
17-Jun-2015
DOI:
10.1016/j.pbiomolbio.2015.06.001
Type:
Article
ISSN:
00796107
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0079610715000760
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC); Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorWalkiewicz, Katarzyna Wiktoriaen
dc.contributor.authorGirault, Jean-Antoineen
dc.contributor.authorArold, Stefan T.en
dc.date.accessioned2015-06-21T09:29:41Zen
dc.date.available2015-06-21T09:29:41Zen
dc.date.issued2015-06-17en
dc.identifier.citationHow to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions 2015 Progress in Biophysics and Molecular Biologyen
dc.identifier.issn00796107en
dc.identifier.doi10.1016/j.pbiomolbio.2015.06.001en
dc.identifier.urihttp://hdl.handle.net/10754/558299en
dc.description.abstractThe focal adhesion kinase (FAK) and the related protein-tyrosine kinase 2-beta (Pyk2) are highly versatile multidomain scaffolds central to cell adhesion, migration, and survival. Due to their key role in cancer metastasis, understanding and inhibiting their functions are important for the development of targeted therapy. Because FAK and Pyk2 are involved in many different cellular functions, designing drugs with partial and function-specific inhibitory effects would be desirable. Here, we summarise recent progress in understanding the structural mechanism of how the tug-of-war between intramolecular and intermolecular interactions allows these protein ‘nanomachines’ to become activated in a site-specific manner.en
dc.publisherElsevier BVen
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0079610715000760en
dc.rightsArchived with thanks to Progress in Biophysics and Molecular Biology. Under a Creative Commons license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectMultidomain proteinen
dc.subjectAdhesomeen
dc.subjectX-ray crystallographyen
dc.subjectMolecular dynamicsen
dc.subjectHybrid methodsen
dc.subjectCalcium signallingen
dc.titleHow to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactionsen
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalProgress in Biophysics and Molecular Biologyen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionInserm, UMR-S 839, F-75005 Paris, Franceen
dc.contributor.institutionUniversité Pierre & Marie Curie (UPMC), Sorbonne Universités, F-75005 Paris, Franceen
dc.contributor.institutionInstitut du Fer à Moulin, F-75005 Paris, Franceen
kaust.authorArold, Stefan T.en
kaust.authorWalkiewicz, Katarzyna Wiktoriaen
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