NeuroLines: A Subway Map Metaphor for Visualizing Nanoscale Neuronal Connectivity

Handle URI:
http://hdl.handle.net/10754/556113
Title:
NeuroLines: A Subway Map Metaphor for Visualizing Nanoscale Neuronal Connectivity
Authors:
Al-Awami, Ali K.; Beyer, Johanna; Strobelt, Hendrik; Kasthuri, Narayanan; Lichtman, Jeff W.; Pfister, Hanspeter; Hadwiger, Markus ( 0000-0003-1239-4871 )
Abstract:
We present NeuroLines, a novel visualization technique designed for scalable detailed analysis of neuronal connectivity at the nanoscale level. The topology of 3D brain tissue data is abstracted into a multi-scale, relative distance-preserving subway map visualization that allows domain scientists to conduct an interactive analysis of neurons and their connectivity. Nanoscale connectomics aims at reverse-engineering the wiring of the brain. Reconstructing and analyzing the detailed connectivity of neurons and neurites (axons, dendrites) will be crucial for understanding the brain and its development and diseases. However, the enormous scale and complexity of nanoscale neuronal connectivity pose big challenges to existing visualization techniques in terms of scalability. NeuroLines offers a scalable visualization framework that can interactively render thousands of neurites, and that supports the detailed analysis of neuronal structures and their connectivity. We describe and analyze the design of NeuroLines based on two real-world use-cases of our collaborators in developmental neuroscience, and investigate its scalability to large-scale neuronal connectivity data.
KAUST Department:
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Citation:
NeuroLines: A Subway Map Metaphor for Visualizing Nanoscale Neuronal Connectivity 2014, 20 (12):2369 IEEE Transactions on Visualization and Computer Graphics
Publisher:
IEEE
Journal:
IEEE Transactions on Visualization and Computer Graphics
Issue Date:
31-Dec-2014
DOI:
10.1109/TVCG.2014.2346312
Type:
Article
ISSN:
1077-2626
Additional Links:
http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=6875935; http://people.seas.harvard.edu/~jbeyer/neurolines.html
Appears in Collections:
Articles; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorAl-Awami, Ali K.en
dc.contributor.authorBeyer, Johannaen
dc.contributor.authorStrobelt, Hendriken
dc.contributor.authorKasthuri, Narayananen
dc.contributor.authorLichtman, Jeff W.en
dc.contributor.authorPfister, Hanspeteren
dc.contributor.authorHadwiger, Markusen
dc.date.accessioned2015-06-02T11:41:20Zen
dc.date.available2015-06-02T11:41:20Zen
dc.date.issued2014-12-31en
dc.identifier.citationNeuroLines: A Subway Map Metaphor for Visualizing Nanoscale Neuronal Connectivity 2014, 20 (12):2369 IEEE Transactions on Visualization and Computer Graphicsen
dc.identifier.issn1077-2626en
dc.identifier.doi10.1109/TVCG.2014.2346312en
dc.identifier.urihttp://hdl.handle.net/10754/556113en
dc.description.abstractWe present NeuroLines, a novel visualization technique designed for scalable detailed analysis of neuronal connectivity at the nanoscale level. The topology of 3D brain tissue data is abstracted into a multi-scale, relative distance-preserving subway map visualization that allows domain scientists to conduct an interactive analysis of neurons and their connectivity. Nanoscale connectomics aims at reverse-engineering the wiring of the brain. Reconstructing and analyzing the detailed connectivity of neurons and neurites (axons, dendrites) will be crucial for understanding the brain and its development and diseases. However, the enormous scale and complexity of nanoscale neuronal connectivity pose big challenges to existing visualization techniques in terms of scalability. NeuroLines offers a scalable visualization framework that can interactively render thousands of neurites, and that supports the detailed analysis of neuronal structures and their connectivity. We describe and analyze the design of NeuroLines based on two real-world use-cases of our collaborators in developmental neuroscience, and investigate its scalability to large-scale neuronal connectivity data.en
dc.publisherIEEEen
dc.relation.urlhttp://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=6875935en
dc.relation.urlhttp://people.seas.harvard.edu/~jbeyer/neurolines.htmlen
dc.rights(c) 2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.en
dc.subjectNeuroscienceen
dc.subjectMulti-Treesen
dc.subjectFocus+Contexten
dc.subjectData Abstractionen
dc.subjectConnectomicsen
dc.titleNeuroLines: A Subway Map Metaphor for Visualizing Nanoscale Neuronal Connectivityen
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.identifier.journalIEEE Transactions on Visualization and Computer Graphicsen
dc.eprint.versionPost-printen
dc.contributor.institutionSchool of Engineering and Applied Sciences at Harvard Universityen
kaust.authorAl-Awami, Alien
kaust.authorHadwiger, Markusen
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