Fano lineshapes of 'Peak-tracking chip' spatial profiles analyzed with correlation analysis for bioarray imaging and refractive index sensing

Handle URI:
http://hdl.handle.net/10754/555710
Title:
Fano lineshapes of 'Peak-tracking chip' spatial profiles analyzed with correlation analysis for bioarray imaging and refractive index sensing
Authors:
Bougot-Robin, K.; Li, S.; Yue, W.; Chen, L. Q.; Zhang, Xixiang ( 0000-0002-3478-6414 ) ; Wen, W. J.; Benisty, H.
Abstract:
The asymmetric Fano resonance lineshapes, resulting from interference between background and a resonant scattering, is archetypal in resonant waveguide grating (RWG) reflectivity. Resonant profile shift resulting from a change of refractive index (from fluid medium or biomolecules at the chip surface) is classically used to perform label-free sensing. Lineshapes are sometimes sampled at discretized “detuning” values to relax instrumental demands, the highest reflectivity element giving a coarse resonance estimate. A finer extraction, needed to increase sensor sensitivity, can be obtained using a correlation approach, correlating the sensed signal to a zero-shifted reference signal. Fabrication process is presented leading to discrete Fano profiles. Our findings are illustrated with resonance profiles from silicon nitride RWGs operated at visible wavelengths. We recently demonstrated that direct imaging multi-assay RWGs sensing may be rendered more reliable using “chirped” RWG chips, by varying a RWG structure parameter. Then, the spatial reflectivity profiles of tracks composed of RWGs units with slowly varying filling factor (thus slowly varying resonance condition) are measured under monochromatic conditions. Extracting the resonance location using spatial Fano profiles allows multiplex refractive index based sensing. Discretization and sensitivity are discussed both through simulation and experiment for different filling factor variation, here Δf=0.0222 and Δf=0.0089. This scheme based on a “Peak-tracking chip” demonstrates a new technique for bioarray imaging using a simpler set-up that maintains high performance with cheap lenses, with down to Δn=2×10-5 RIU sensitivity for the highest sampling of Fano lineshapes. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
KAUST Department:
Advanced Nanofabrication, Imaging and Characterization Core Lab; KAUST-HKUST Micro/Nanofluidic Joint Laboratory
Citation:
Bougot-Robin, Kristelle, Shunbo Li, Weisheng Yue, L. Q. Chen, X. X. Zhang, W. J. Wen, and Henri Benisty. "Fano lineshapes of'Peak-tracking chip'spatial profiles analyzed with correlation analysis for bioarray imaging and refractive index sensing." In SPIE Microtechnologies, pp. 876703-876703. International Society for Optics and Photonics, 2013
Publisher:
SPIE-Intl Soc Optical Eng
Journal:
Integrated Photonics: Materials, Devices, and Applications II
Conference/Event name:
Integrated Photonics: Materials, Devices, and Applications II
Issue Date:
22-May-2013
DOI:
10.1117/12.2018316
Type:
Conference Paper
Additional Links:
http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2018316
Appears in Collections:
Conference Papers; Advanced Nanofabrication, Imaging and Characterization Core Lab; Advanced Nanofabrication, Imaging and Characterization Core Lab

Full metadata record

DC FieldValue Language
dc.contributor.authorBougot-Robin, K.en
dc.contributor.authorLi, S.en
dc.contributor.authorYue, W.en
dc.contributor.authorChen, L. Q.en
dc.contributor.authorZhang, Xixiangen
dc.contributor.authorWen, W. J.en
dc.contributor.authorBenisty, H.en
dc.date.accessioned2015-05-25T14:48:59Zen
dc.date.available2015-05-25T14:48:59Zen
dc.date.issued2013-05-22en
dc.identifier.citationBougot-Robin, Kristelle, Shunbo Li, Weisheng Yue, L. Q. Chen, X. X. Zhang, W. J. Wen, and Henri Benisty. "Fano lineshapes of'Peak-tracking chip'spatial profiles analyzed with correlation analysis for bioarray imaging and refractive index sensing." In SPIE Microtechnologies, pp. 876703-876703. International Society for Optics and Photonics, 2013en
dc.identifier.doi10.1117/12.2018316en
dc.identifier.urihttp://hdl.handle.net/10754/555710en
dc.description.abstractThe asymmetric Fano resonance lineshapes, resulting from interference between background and a resonant scattering, is archetypal in resonant waveguide grating (RWG) reflectivity. Resonant profile shift resulting from a change of refractive index (from fluid medium or biomolecules at the chip surface) is classically used to perform label-free sensing. Lineshapes are sometimes sampled at discretized “detuning” values to relax instrumental demands, the highest reflectivity element giving a coarse resonance estimate. A finer extraction, needed to increase sensor sensitivity, can be obtained using a correlation approach, correlating the sensed signal to a zero-shifted reference signal. Fabrication process is presented leading to discrete Fano profiles. Our findings are illustrated with resonance profiles from silicon nitride RWGs operated at visible wavelengths. We recently demonstrated that direct imaging multi-assay RWGs sensing may be rendered more reliable using “chirped” RWG chips, by varying a RWG structure parameter. Then, the spatial reflectivity profiles of tracks composed of RWGs units with slowly varying filling factor (thus slowly varying resonance condition) are measured under monochromatic conditions. Extracting the resonance location using spatial Fano profiles allows multiplex refractive index based sensing. Discretization and sensitivity are discussed both through simulation and experiment for different filling factor variation, here Δf=0.0222 and Δf=0.0089. This scheme based on a “Peak-tracking chip” demonstrates a new technique for bioarray imaging using a simpler set-up that maintains high performance with cheap lenses, with down to Δn=2×10-5 RIU sensitivity for the highest sampling of Fano lineshapes. © (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.en
dc.publisherSPIE-Intl Soc Optical Engen
dc.relation.urlhttp://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2018316en
dc.rightsArchived with thanks to Proceedings of SPIEen
dc.titleFano lineshapes of 'Peak-tracking chip' spatial profiles analyzed with correlation analysis for bioarray imaging and refractive index sensingen
dc.typeConference Paperen
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Laben
dc.contributor.departmentKAUST-HKUST Micro/Nanofluidic Joint Laboratoryen
dc.identifier.journalIntegrated Photonics: Materials, Devices, and Applications IIen
dc.conference.date2013-04-24 to 2013-04-26en
dc.conference.nameIntegrated Photonics: Materials, Devices, and Applications IIen
dc.conference.locationGrenoble, USAen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionInstitute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong-Kong, Chinaen
dc.contributor.institutionDepartment of Physics, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong-Kong, Chinaen
dc.contributor.institutionLaboratoire Charles Fabry, Institut Optique Graduate School, 2 avenue Fresnel, CNRS, Univ P Sud, 91127 Palaiseau, Franceen
kaust.authorYue, Weishengen
kaust.authorChen, Longqingen
kaust.authorZhang, Xixiangen
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