Importance of the Genetic Diversity within the Mycobacterium tuberculosis Complex for the Development of Novel Antibiotics and Diagnostic Tests of Drug Resistance

Handle URI:
http://hdl.handle.net/10754/554104
Title:
Importance of the Genetic Diversity within the Mycobacterium tuberculosis Complex for the Development of Novel Antibiotics and Diagnostic Tests of Drug Resistance
Authors:
Koser, C. U.; Feuerriegel, S.; Summers, D. K.; Archer, John A.C. ( 0000-0002-3302-3933 ) ; Niemann, S.
Abstract:
Despite being genetically monomorphic, the limited genetic diversity within the Mycobacterium tuberculosis complex (MTBC) has practical consequences for molecular methods for drug susceptibility testing and for the use of current antibiotics and those in clinical trials. It renders some representatives of MTBC intrinsically resistant against one or multiple antibiotics and affects the spectrum and consequences of resistance mutations selected for during treatment. Moreover, neutral or silent changes within genes responsible for drug resistance can cause false-positive results with hybridization-based assays, which have been recently introduced to replace slower phenotypic methods. We discuss the consequences of these findings and propose concrete steps to rigorously assess the genetic diversity of MTBC to support ongoing clinical trials.
KAUST Department:
Computational Bioscience Research Center (CBRC)
Citation:
Importance of the Genetic Diversity within the Mycobacterium tuberculosis Complex for the Development of Novel Antibiotics and Diagnostic Tests of Drug Resistance 2012, 56 (12):6080 Antimicrobial Agents and Chemotherapy
Journal:
Antimicrobial Agents and Chemotherapy
Issue Date:
24-Sep-2012
DOI:
10.1128/AAC.01641-12
PubMed ID:
23006760
PubMed Central ID:
PMC3497208
Type:
Article
ISSN:
0066-4804; 1098-6596
Additional Links:
http://aac.asm.org/cgi/doi/10.1128/AAC.01641-12
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC); Computational Bioscience Research Center (CBRC)

Full metadata record

DC FieldValue Language
dc.contributor.authorKoser, C. U.en
dc.contributor.authorFeuerriegel, S.en
dc.contributor.authorSummers, D. K.en
dc.contributor.authorArcher, John A.C.en
dc.contributor.authorNiemann, S.en
dc.date.accessioned2015-05-18T21:52:32Zen
dc.date.available2015-05-18T21:52:32Zen
dc.date.issued2012-09-24en
dc.identifier.citationImportance of the Genetic Diversity within the Mycobacterium tuberculosis Complex for the Development of Novel Antibiotics and Diagnostic Tests of Drug Resistance 2012, 56 (12):6080 Antimicrobial Agents and Chemotherapyen
dc.identifier.issn0066-4804en
dc.identifier.issn1098-6596en
dc.identifier.pmid23006760en
dc.identifier.doi10.1128/AAC.01641-12en
dc.identifier.urihttp://hdl.handle.net/10754/554104en
dc.description.abstractDespite being genetically monomorphic, the limited genetic diversity within the Mycobacterium tuberculosis complex (MTBC) has practical consequences for molecular methods for drug susceptibility testing and for the use of current antibiotics and those in clinical trials. It renders some representatives of MTBC intrinsically resistant against one or multiple antibiotics and affects the spectrum and consequences of resistance mutations selected for during treatment. Moreover, neutral or silent changes within genes responsible for drug resistance can cause false-positive results with hybridization-based assays, which have been recently introduced to replace slower phenotypic methods. We discuss the consequences of these findings and propose concrete steps to rigorously assess the genetic diversity of MTBC to support ongoing clinical trials.en
dc.relation.urlhttp://aac.asm.org/cgi/doi/10.1128/AAC.01641-12en
dc.rightsArchived with thanks to Antimicrobial Agents and Chemotherapyen
dc.titleImportance of the Genetic Diversity within the Mycobacterium tuberculosis Complex for the Development of Novel Antibiotics and Diagnostic Tests of Drug Resistanceen
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalAntimicrobial Agents and Chemotherapyen
dc.identifier.pmcidPMC3497208en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDepartment of Medicine, University of Cambridge, Cambridge, United Kingdomen
dc.contributor.institutionHealth Protection Agency, Cambridge, United Kingdomen
dc.contributor.institutionMolecular Mycobacteriology, Research Center Borstel, Borstel, Germanyen
dc.contributor.institutionDepartment of Genetics, University of Cambridge, Cambridge, United Kingdomen
kaust.authorArcher, John A.C.en

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