Polymorphisms in Isoniazid and Prothionamide Resistance Genes of the Mycobacterium tuberculosis Complex

Handle URI:
http://hdl.handle.net/10754/554098
Title:
Polymorphisms in Isoniazid and Prothionamide Resistance Genes of the Mycobacterium tuberculosis Complex
Authors:
Projahn, M.; Koser, C. U.; Homolka, S.; Summers, D. K.; Archer, John A.C. ( 0000-0002-3302-3933 ) ; Niemann, S.
Abstract:
Sequence analyses of 74 strains that encompassed major phylogenetic lineages of the Mycobacterium tuberculosis complex revealed 10 polymorphisms in mshA (Rv0486) and four polymorphisms in inhA (Rv1484) that were not responsible for isoniazid or prothionamide resistance. Instead, some of these mutations were phylogenetically informative. This genetic diversity must be taken into consideration for drug development and for the design of molecular tests for drug resistance.
KAUST Department:
Computational Bioscience Research Center (CBRC)
Citation:
Polymorphisms in Isoniazid and Prothionamide Resistance Genes of the Mycobacterium tuberculosis Complex 2011, 55 (9):4408 Antimicrobial Agents and Chemotherapy
Journal:
Antimicrobial Agents and Chemotherapy
Issue Date:
27-Jun-2011
DOI:
10.1128/AAC.00555-11
PubMed ID:
21709103
PubMed Central ID:
PMC3165319
Type:
Article
ISSN:
0066-4804; 1098-6596
Additional Links:
http://aac.asm.org/cgi/doi/10.1128/AAC.00555-11
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC); Computational Bioscience Research Center (CBRC)

Full metadata record

DC FieldValue Language
dc.contributor.authorProjahn, M.en
dc.contributor.authorKoser, C. U.en
dc.contributor.authorHomolka, S.en
dc.contributor.authorSummers, D. K.en
dc.contributor.authorArcher, John A.C.en
dc.contributor.authorNiemann, S.en
dc.date.accessioned2015-05-18T21:39:14Zen
dc.date.available2015-05-18T21:39:14Zen
dc.date.issued2011-06-27en
dc.identifier.citationPolymorphisms in Isoniazid and Prothionamide Resistance Genes of the Mycobacterium tuberculosis Complex 2011, 55 (9):4408 Antimicrobial Agents and Chemotherapyen
dc.identifier.issn0066-4804en
dc.identifier.issn1098-6596en
dc.identifier.pmid21709103en
dc.identifier.doi10.1128/AAC.00555-11en
dc.identifier.urihttp://hdl.handle.net/10754/554098en
dc.description.abstractSequence analyses of 74 strains that encompassed major phylogenetic lineages of the Mycobacterium tuberculosis complex revealed 10 polymorphisms in mshA (Rv0486) and four polymorphisms in inhA (Rv1484) that were not responsible for isoniazid or prothionamide resistance. Instead, some of these mutations were phylogenetically informative. This genetic diversity must be taken into consideration for drug development and for the design of molecular tests for drug resistance.en
dc.relation.urlhttp://aac.asm.org/cgi/doi/10.1128/AAC.00555-11en
dc.rightsArchived with thanks to Antimicrobial Agents and Chemotherapyen
dc.titlePolymorphisms in Isoniazid and Prothionamide Resistance Genes of the Mycobacterium tuberculosis Complexen
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalAntimicrobial Agents and Chemotherapyen
dc.identifier.pmcidPMC3165319en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionMolecular Mycobacteriology, Research Center Borstel, Parkallee 1, 23845 Borstel, Germanyen
dc.contributor.institutionDepartment of Genetics, University of Cambridge, Cambridge, United Kingdomen
kaust.authorArcher, John A.C.en
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