A Sensitivity Analysis of fMRI Balloon Model

Handle URI:
http://hdl.handle.net/10754/552988
Title:
A Sensitivity Analysis of fMRI Balloon Model
Authors:
Zayane, Chadia ( 0000-0002-3035-3048 ) ; Laleg-Kirati, Taous-Meriem ( 0000-0001-5944-0121 )
Abstract:
Functional magnetic resonance imaging (fMRI) allows the mapping of the brain activation through measurements of the Blood Oxygenation Level Dependent (BOLD) contrast. The characterization of the pathway from the input stimulus to the output BOLD signal requires the selection of an adequate hemodynamic model and the satisfaction of some specific conditions while conducting the experiment and calibrating the model. This paper, focuses on the identifiability of the Balloon hemodynamic model. By identifiability, we mean the ability to estimate accurately the model parameters given the input and the output measurement. Previous studies of the Balloon model have somehow added knowledge either by choosing prior distributions for the parameters, freezing some of them, or looking for the solution as a projection on a natural basis of some vector space. In these studies, the identification was generally assessed using event-related paradigms. This paper justifies the reasons behind the need of adding knowledge, choosing certain paradigms, and completing the few existing identifiability studies through a global sensitivity analysis of the Balloon model in the case of blocked design experiment.
KAUST Department:
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Citation:
A Sensitivity Analysis of fMRI Balloon Model 2015, 2015:1 Computational and Mathematical Methods in Medicine
Journal:
Computational and Mathematical Methods in Medicine
Issue Date:
22-Apr-2015
DOI:
10.1155/2015/425475
PubMed ID:
26078776
PubMed Central ID:
PMC4442414
Type:
Article
ISSN:
1748-670X; 1748-6718
Additional Links:
http://www.hindawi.com/journals/cmmm/2015/425475/
Appears in Collections:
Articles; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorZayane, Chadiaen
dc.contributor.authorLaleg-Kirati, Taous-Meriemen
dc.date.accessioned2015-05-17T20:42:07Zen
dc.date.available2015-05-17T20:42:07Zen
dc.date.issued2015-04-22en
dc.identifier.citationA Sensitivity Analysis of fMRI Balloon Model 2015, 2015:1 Computational and Mathematical Methods in Medicineen
dc.identifier.issn1748-670Xen
dc.identifier.issn1748-6718en
dc.identifier.pmid26078776en
dc.identifier.doi10.1155/2015/425475en
dc.identifier.urihttp://hdl.handle.net/10754/552988en
dc.description.abstractFunctional magnetic resonance imaging (fMRI) allows the mapping of the brain activation through measurements of the Blood Oxygenation Level Dependent (BOLD) contrast. The characterization of the pathway from the input stimulus to the output BOLD signal requires the selection of an adequate hemodynamic model and the satisfaction of some specific conditions while conducting the experiment and calibrating the model. This paper, focuses on the identifiability of the Balloon hemodynamic model. By identifiability, we mean the ability to estimate accurately the model parameters given the input and the output measurement. Previous studies of the Balloon model have somehow added knowledge either by choosing prior distributions for the parameters, freezing some of them, or looking for the solution as a projection on a natural basis of some vector space. In these studies, the identification was generally assessed using event-related paradigms. This paper justifies the reasons behind the need of adding knowledge, choosing certain paradigms, and completing the few existing identifiability studies through a global sensitivity analysis of the Balloon model in the case of blocked design experiment.en
dc.relation.urlhttp://www.hindawi.com/journals/cmmm/2015/425475/en
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/en
dc.titleA Sensitivity Analysis of fMRI Balloon Modelen
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.identifier.journalComputational and Mathematical Methods in Medicineen
dc.identifier.pmcidPMC4442414en
dc.eprint.versionPublisher's Version/PDFen
kaust.authorZayane, Chadiaen
kaust.authorLaleg-Kirati, Taous-Meriemen

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