On-chip bio-analyte detection utilizing the velocity of magnetic microparticles in a fluid

Handle URI:
http://hdl.handle.net/10754/552757
Title:
On-chip bio-analyte detection utilizing the velocity of magnetic microparticles in a fluid
Authors:
Giouroudi, Ioanna; van den Driesche, Sander; Kosel, Jürgen ( 0000-0002-8998-8275 ) ; Grössinger, Roland; Vellekoop, Michael J.
Abstract:
A biosensing principle utilizing the motion of suspended magnetic microparticles in a microfluidic system is presented. The system utilizes the innovative concept of the velocity dependence of magnetic microparticles (MPs) due to their volumetric change when analyte is attached to their surface via antibody–antigen binding. When the magnetic microparticles are attracted by a magnetic field within a microfluidic channel their velocity depends on the presence of analyte. Specifically, their velocity decreases drastically when the magnetic microparticles are covered by (nonmagnetic) analyte (LMPs) due to the increased drag force in the opposite direction to that of the magnetic force. Experiments were carried out as a proof of concept. A promising 52% decrease in the velocity of the LMPs in comparison to that of the MPs was measured when both of them were accelerated inside a microfluidic channel using an external permanent magnet. The presented biosensing methodology offers a compact and integrated solution for a new kind of on-chip analysis with potentially high sensitivity and shorter acquisition time than conventional laboratory based systems.
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Citation:
On-chip bio-analyte detection utilizing the velocity of magnetic microparticles in a fluid 2011, 109 (7):07B304 Journal of Applied Physics
Publisher:
AIP Publishing
Journal:
Journal of Applied Physics
Issue Date:
22-Mar-2011
DOI:
10.1063/1.3556952
Type:
Article
ISSN:
00218979
Additional Links:
http://scitation.aip.org/content/aip/journal/jap/109/7/10.1063/1.3556952
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorGiouroudi, Ioannaen
dc.contributor.authorvan den Driesche, Sanderen
dc.contributor.authorKosel, Jürgenen
dc.contributor.authorGrössinger, Rolanden
dc.contributor.authorVellekoop, Michael J.en
dc.date.accessioned2015-05-14T07:07:11Zen
dc.date.available2015-05-14T07:07:11Zen
dc.date.issued2011-03-22en
dc.identifier.citationOn-chip bio-analyte detection utilizing the velocity of magnetic microparticles in a fluid 2011, 109 (7):07B304 Journal of Applied Physicsen
dc.identifier.issn00218979en
dc.identifier.doi10.1063/1.3556952en
dc.identifier.urihttp://hdl.handle.net/10754/552757en
dc.description.abstractA biosensing principle utilizing the motion of suspended magnetic microparticles in a microfluidic system is presented. The system utilizes the innovative concept of the velocity dependence of magnetic microparticles (MPs) due to their volumetric change when analyte is attached to their surface via antibody–antigen binding. When the magnetic microparticles are attracted by a magnetic field within a microfluidic channel their velocity depends on the presence of analyte. Specifically, their velocity decreases drastically when the magnetic microparticles are covered by (nonmagnetic) analyte (LMPs) due to the increased drag force in the opposite direction to that of the magnetic force. Experiments were carried out as a proof of concept. A promising 52% decrease in the velocity of the LMPs in comparison to that of the MPs was measured when both of them were accelerated inside a microfluidic channel using an external permanent magnet. The presented biosensing methodology offers a compact and integrated solution for a new kind of on-chip analysis with potentially high sensitivity and shorter acquisition time than conventional laboratory based systems.en
dc.publisherAIP Publishingen
dc.relation.urlhttp://scitation.aip.org/content/aip/journal/jap/109/7/10.1063/1.3556952en
dc.rightsArchived with thanks to Journal of Applied Physicsen
dc.titleOn-chip bio-analyte detection utilizing the velocity of magnetic microparticles in a fluiden
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalJournal of Applied Physicsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionInstitute of Sensor and Actuator Systems, Vienna University of Technology, 1040, Vienna, Austriaen
dc.contributor.institutionInstitute of Solid State Physics, Vienna University of Technology, 1040, Vienna, Austriaen
kaust.authorKosel, Jürgenen
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