Biosensing utilizing the motion of magnetic microparticles in a microfluidic system

Handle URI:
http://hdl.handle.net/10754/552525
Title:
Biosensing utilizing the motion of magnetic microparticles in a microfluidic system
Authors:
Giouroudi, Ioanna; Driesche, Sander van den; Kosel, Jürgen ( 0000-0002-8998-8275 )
Abstract:
The study for the design of a compact and inexpensive biosensing device, which can be operated either by primary care personnel or by patients as opposed to skilled operators, is presented. The main parts of the proposed device are a microfluidic channel, permanent magnets and functionalized magnetic microparticles. The innovative aspect of the proposed biosensing method is that it utilizes the volumetric increase of magnetic microparticles when analyte binds to their surface. Their velocity decreases drastically when they are accelerated by an externally applied magnetic force within a microfluidic channel. This effect is utilized to detect the presence of analyte e.g. microbes. Analytical calculations showed that a decrease in velocity of approximately 23% can be achieved due to the volumetric change of a magnetic microparticle of View the MathML source1μm diameter when HIV virions of approximately View the MathML source0,135μm are bound to its surface and by keeping its magnetic properties the same. Preliminary experiments were carried out utilizing superparamagnetic microparticles coated with streptavidin and polystyrene microparticles coated with biotin.
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Citation:
Biosensing utilizing the motion of magnetic microparticles in a microfluidic system 2010, 5:824 Procedia Engineering
Journal:
Procedia Engineering
Conference/Event name:
24th Eurosensors Conference
Issue Date:
23-Oct-2010
DOI:
10.1016/j.proeng.2010.09.235
Type:
Conference Paper
ISSN:
18777058
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S1877705810007824
Appears in Collections:
Conference Papers; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorGiouroudi, Ioannaen
dc.contributor.authorDriesche, Sander van denen
dc.contributor.authorKosel, Jürgenen
dc.date.accessioned2015-05-10T14:18:37Zen
dc.date.available2015-05-10T14:18:37Zen
dc.date.issued2010-10-23en
dc.identifier.citationBiosensing utilizing the motion of magnetic microparticles in a microfluidic system 2010, 5:824 Procedia Engineeringen
dc.identifier.issn18777058en
dc.identifier.doi10.1016/j.proeng.2010.09.235en
dc.identifier.urihttp://hdl.handle.net/10754/552525en
dc.description.abstractThe study for the design of a compact and inexpensive biosensing device, which can be operated either by primary care personnel or by patients as opposed to skilled operators, is presented. The main parts of the proposed device are a microfluidic channel, permanent magnets and functionalized magnetic microparticles. The innovative aspect of the proposed biosensing method is that it utilizes the volumetric increase of magnetic microparticles when analyte binds to their surface. Their velocity decreases drastically when they are accelerated by an externally applied magnetic force within a microfluidic channel. This effect is utilized to detect the presence of analyte e.g. microbes. Analytical calculations showed that a decrease in velocity of approximately 23% can be achieved due to the volumetric change of a magnetic microparticle of View the MathML source1μm diameter when HIV virions of approximately View the MathML source0,135μm are bound to its surface and by keeping its magnetic properties the same. Preliminary experiments were carried out utilizing superparamagnetic microparticles coated with streptavidin and polystyrene microparticles coated with biotin.en
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S1877705810007824en
dc.rightsArchived with thanks to Procedia Engineering. http://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectMicrofluidicsen
dc.subjectMagnetic microparticlesen
dc.subjectBiosensorsen
dc.subjectOn chipen
dc.titleBiosensing utilizing the motion of magnetic microparticles in a microfluidic systemen
dc.typeConference Paperen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalProcedia Engineeringen
dc.conference.date2010-09-05 to 2010-09-08en
dc.conference.name24th Eurosensors Conferenceen
dc.conference.locationLinz, AUTen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionInstitute of Sensor and Actuator Systems, Vienna University of Technology, Gusshausstrasse 27-29/366-ISS, Vienna, 1040, Austriaen
kaust.authorKosel, Jürgenen
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