Stimuli-Responsive Materials for Controlled Release Applications

Handle URI:
http://hdl.handle.net/10754/552156
Title:
Stimuli-Responsive Materials for Controlled Release Applications
Authors:
Li, Song ( 0000-0003-4463-733X )
Abstract:
The controlled release of therapeutics has been one of the major challenges for scientists and engineers during the past three decades. To address this outstanding problem, the design and fabrication of stimuli-responsive materials are pursued to guarantee the controlled release of cargo at a specific time and with an accurate amount. Upon applying different stimuli such as light, magnetic field, heat, pH change, enzymes or redox, functional materials change their physicochemical properties through physical transformation or chemical reactions, allowing the release of payload agents on demand. This dissertation studied three stimuli-responsive membrane systems for controlled release from films of macro sizes to microcapsules of nano sizes. The first membrane system is a polymeric composite film which can decrease and sustain diffusion upon light irradiation. The photo-response of membranes is based on the photoreaction of cinnamic derivatives. The second one is composite membrane which can improve diffusion upon heating. The thermo-response of membranes comes from the volume phase transition ability of hydrogels. The third one is microcapsule which can release encapsulated agents upon light irradiation. The photo-response of capsules results from the photoreaction of nitrobenzyl derivatives. The study on these membrane systems reveals that stimuli-responsive release can be achieved by utilizing different functional materials on either macro or micro level. Based on the abundant family of smart materials, designing and fabricating stimuli-responsive systems shall lead to various advanced release processes on demand for biomedical applications.
Advisors:
Khashab, Niveen M. ( 0000-0003-2728-0666 )
Committee Member:
Hadjichristidis, Nikolaos ( 0000-0003-1442-1714 ) ; Han, Yu ( 0000-0003-1462-1118 ) ; Kosel, Jürgen ( 0000-0002-8998-8275 )
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Program:
Chemical Sciences
Issue Date:
Apr-2015
Type:
Dissertation
Appears in Collections:
Dissertations; Physical Sciences and Engineering (PSE) Division; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.advisorKhashab, Niveen M.en
dc.contributor.authorLi, Songen
dc.date.accessioned2015-05-04T13:57:18Zen
dc.date.available2015-05-04T13:57:18Zen
dc.date.issued2015-04en
dc.identifier.urihttp://hdl.handle.net/10754/552156en
dc.description.abstractThe controlled release of therapeutics has been one of the major challenges for scientists and engineers during the past three decades. To address this outstanding problem, the design and fabrication of stimuli-responsive materials are pursued to guarantee the controlled release of cargo at a specific time and with an accurate amount. Upon applying different stimuli such as light, magnetic field, heat, pH change, enzymes or redox, functional materials change their physicochemical properties through physical transformation or chemical reactions, allowing the release of payload agents on demand. This dissertation studied three stimuli-responsive membrane systems for controlled release from films of macro sizes to microcapsules of nano sizes. The first membrane system is a polymeric composite film which can decrease and sustain diffusion upon light irradiation. The photo-response of membranes is based on the photoreaction of cinnamic derivatives. The second one is composite membrane which can improve diffusion upon heating. The thermo-response of membranes comes from the volume phase transition ability of hydrogels. The third one is microcapsule which can release encapsulated agents upon light irradiation. The photo-response of capsules results from the photoreaction of nitrobenzyl derivatives. The study on these membrane systems reveals that stimuli-responsive release can be achieved by utilizing different functional materials on either macro or micro level. Based on the abundant family of smart materials, designing and fabricating stimuli-responsive systems shall lead to various advanced release processes on demand for biomedical applications.en
dc.language.isoenen
dc.subjectcontrolled releaseen
dc.subjectstimuli-responseen
dc.subjectphoto-responseen
dc.subjectcomposite membraneen
dc.subjectcolloidosomeen
dc.titleStimuli-Responsive Materials for Controlled Release Applicationsen
dc.typeDissertationen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
thesis.degree.grantorKing Abdullah University of Science and Technologyen_GB
dc.contributor.committeememberHadjichristidis, Nikolaosen
dc.contributor.committeememberHan, Yuen
dc.contributor.committeememberKosel, Jürgenen
thesis.degree.disciplineChemical Sciencesen
thesis.degree.nameDoctor of Philosophyen
dc.person.id118442en
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.