Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles

Handle URI:
http://hdl.handle.net/10754/550220
Title:
Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles
Authors:
Wang, Xiang; Li, Shunbo; Wang, Limu; Yi, Xin; Hui, Yu Sanna; Qin, Jianhua; Wen, Weijia
Abstract:
We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.
KAUST Department:
KAUST-HKUST Joint Micro/Nanofluidic Laboratory
Citation:
Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles 2013, 2013:1 Journal of Nanomaterials
Publisher:
Hindawi Publishing Corporation
Journal:
Journal of Nanomaterials
Issue Date:
Jan-2013
DOI:
10.1155/2013/864584
Type:
Article
ISSN:
1687-4110; 1687-4129
Additional Links:
http://www.hindawi.com/journals/jnm/2013/864584/
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorWang, Xiangen
dc.contributor.authorLi, Shunboen
dc.contributor.authorWang, Limuen
dc.contributor.authorYi, Xinen
dc.contributor.authorHui, Yu Sannaen
dc.contributor.authorQin, Jianhuaen
dc.contributor.authorWen, Weijiaen
dc.date.accessioned2015-04-16T14:03:08Zen
dc.date.available2015-04-16T14:03:08Zen
dc.date.issued2013-01en
dc.identifier.citationMicrofluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles 2013, 2013:1 Journal of Nanomaterialsen
dc.identifier.issn1687-4110en
dc.identifier.issn1687-4129en
dc.identifier.doi10.1155/2013/864584en
dc.identifier.urihttp://hdl.handle.net/10754/550220en
dc.description.abstractWe report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.en
dc.publisherHindawi Publishing Corporationen
dc.relation.urlhttp://www.hindawi.com/journals/jnm/2013/864584/en
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproductio n in any medium, provided the original work is properly cited.en
dc.titleMicrofluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticlesen
dc.typeArticleen
dc.contributor.departmentKAUST-HKUST Joint Micro/Nanofluidic Laboratoryen
dc.identifier.journalJournal of Nanomaterialsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionNanoscience and Nanotechnology Program, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kongen
dc.contributor.institutionDepartment of Physics, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kongen
dc.contributor.institutionDalian Institute of Chemical Physics, Chinese Academy of Science, 457 Zhongshan Road, Dalian, Chinaen
kaust.authorLi, Shunboen
kaust.authorWen, Weijiaen
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