Acute Toxicity of the Antifouling Compound Butenolide in Non-Target Organisms

Handle URI:
http://hdl.handle.net/10754/550219
Title:
Acute Toxicity of the Antifouling Compound Butenolide in Non-Target Organisms
Authors:
Zhang, Yi-Fan; Xiao, Kang; Chandramouli, Kondethimmanahalli ( 0000-0002-0104-1993 ) ; Xu, Ying; Pan, Ke; Wang, Wen-Xiong; Qian, Pei-Yuan
Abstract:
Butenolide [5-octylfuran-2(5H)-one] is a recently discovered and very promising anti-marine-fouling compound. In this study, the acute toxicity of butenolide was assessed in several non-target organisms, including micro algae, crustaceans, and fish. Results were compared with previously reported results on the effective concentrations used on fouling (target) organisms. According to OECD's guideline, the predicted no effect concentration (PNEC) was 0.168 µg l^(−1), which was among one of the highest in representative new biocides. Mechanistically, the phenotype of butenolide-treated Danio rerio (zebrafish) embryos was similar to the phenotype of the pro-caspase-3 over-expression mutant with pericardial edema, small eyes, small brains, and increased numbers of apoptotic cells in the bodies of zebrafish embryos. Butenolide also induced apoptosis in HeLa cells, with the activation of c-Jun N-terminal kinases (JNK), Bcl-2 family proteins, and caspases and proteasomes/lysosomes involved in this process. This is the first detailed toxicity and toxicology study on this antifouling compound.
Citation:
Acute Toxicity of the Antifouling Compound Butenolide in Non-Target Organisms 2011, 6 (8):e23803 PLoS ONE
Publisher:
Public Library of Science (PLoS)
Journal:
PLoS ONE
KAUST Grant Number:
SA-C0040; UK-C0016
Issue Date:
29-Aug-2011
DOI:
10.1371/journal.pone.0023803
PubMed ID:
21897857
PubMed Central ID:
PMC3163639
Type:
Article
ISSN:
1932-6203
Sponsors:
This work was supported by an award [SA-C0040/UK-C0016] from the King Abdullah University of Science and Technology (http://www.kaust.edu.sa/) and grants from the Research Grants Council of HKSAR (http://www.ugc.edu.hk/eng/rgc/index.htm) [N_HKUST602/09, AoE/P-04/04-2-II] to PY Qian. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Additional Links:
http://dx.plos.org/10.1371/journal.pone.0023803
Appears in Collections:
Publications Acknowledging KAUST Support

Full metadata record

DC FieldValue Language
dc.contributor.authorZhang, Yi-Fanen
dc.contributor.authorXiao, Kangen
dc.contributor.authorChandramouli, Kondethimmanahallien
dc.contributor.authorXu, Yingen
dc.contributor.authorPan, Keen
dc.contributor.authorWang, Wen-Xiongen
dc.contributor.authorQian, Pei-Yuanen
dc.date.accessioned2015-04-16T14:02:34Zen
dc.date.available2015-04-16T14:02:34Zen
dc.date.issued2011-08-29en
dc.identifier.citationAcute Toxicity of the Antifouling Compound Butenolide in Non-Target Organisms 2011, 6 (8):e23803 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid21897857en
dc.identifier.doi10.1371/journal.pone.0023803en
dc.identifier.urihttp://hdl.handle.net/10754/550219en
dc.description.abstractButenolide [5-octylfuran-2(5H)-one] is a recently discovered and very promising anti-marine-fouling compound. In this study, the acute toxicity of butenolide was assessed in several non-target organisms, including micro algae, crustaceans, and fish. Results were compared with previously reported results on the effective concentrations used on fouling (target) organisms. According to OECD's guideline, the predicted no effect concentration (PNEC) was 0.168 µg l^(−1), which was among one of the highest in representative new biocides. Mechanistically, the phenotype of butenolide-treated Danio rerio (zebrafish) embryos was similar to the phenotype of the pro-caspase-3 over-expression mutant with pericardial edema, small eyes, small brains, and increased numbers of apoptotic cells in the bodies of zebrafish embryos. Butenolide also induced apoptosis in HeLa cells, with the activation of c-Jun N-terminal kinases (JNK), Bcl-2 family proteins, and caspases and proteasomes/lysosomes involved in this process. This is the first detailed toxicity and toxicology study on this antifouling compound.en
dc.description.sponsorshipThis work was supported by an award [SA-C0040/UK-C0016] from the King Abdullah University of Science and Technology (http://www.kaust.edu.sa/) and grants from the Research Grants Council of HKSAR (http://www.ugc.edu.hk/eng/rgc/index.htm) [N_HKUST602/09, AoE/P-04/04-2-II] to PY Qian. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.publisherPublic Library of Science (PLoS)en
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0023803en
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.titleAcute Toxicity of the Antifouling Compound Butenolide in Non-Target Organismsen
dc.typeArticleen
dc.identifier.journalPLoS ONEen
dc.identifier.pmcidPMC3163639en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDivision of Life Science, Hong Kong University of Division of Life Science, Hong Kong University of Science and Technology, Hong Kong, SAR, ChinaScience and Technology, Hong Kong SAR, Chinaen
kaust.authorZhang, Yi-Fanen
kaust.authorXiao, Kangen
kaust.authorChandramouli, Kondethimmanahallien
kaust.authorXu, Yingen
kaust.authorQian, Pei-Yuanen
kaust.grant.numberSA-C0040en
kaust.grant.numberUK-C0016en
kaust.grant.programKAUST Global Collaborative Research Programen
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