Structural Molecular Components of Septate Junctions in Cnidarians Point to the Origin of Epithelial Junctions in Eukaryotes

Handle URI:
http://hdl.handle.net/10754/550141
Title:
Structural Molecular Components of Septate Junctions in Cnidarians Point to the Origin of Epithelial Junctions in Eukaryotes
Authors:
Ganot, P.; Zoccola, D.; Tambutte, E.; Voolstra, Christian R. ( 0000-0003-4555-3795 ) ; Aranda, Manuel ( 0000-0001-6673-016X ) ; Allemand, D.; Tambutte, S.
Abstract:
Septate junctions (SJs) insure barrier properties and control paracellular diffusion of solutes across epithelia in invertebrates. However, the origin and evolution of their molecular constituents in Metazoa have not been firmly established. Here, we investigated the genomes of early branching metazoan representatives to reconstruct the phylogeny of the molecular components of SJs. Although Claudins and SJ cytoplasmic adaptor components appeared successively throughout metazoan evolution, the structural components of SJs arose at the time of Placozoa/Cnidaria/Bilateria radiation. We also show that in the scleractinian coral Stylophora pistillata, the structural SJ component Neurexin IV colocalizes with the cortical actin network at the apical border of the cells, at the place of SJs. We propose a model for SJ components in Cnidaria. Moreover, our study reveals an unanticipated diversity of SJ structural component variants in cnidarians. This diversity correlates with gene-specific expression in calcifying and noncalcifying tissues, suggesting specific paracellular pathways across the cell layers of these diploblastic animals.
KAUST Department:
Red Sea Research Center (RSRC)
Citation:
Structural Molecular Components of Septate Junctions in Cnidarians Point to the Origin of Epithelial Junctions in Eukaryotes 2014, 32 (1):44 Molecular Biology and Evolution
Publisher:
Oxford University Press (OUP)
Journal:
Molecular Biology and Evolution
Issue Date:
21-Sep-2014
DOI:
10.1093/molbev/msu265
Type:
Article
ISSN:
0737-4038; 1537-1719
Additional Links:
http://mbe.oxfordjournals.org/cgi/doi/10.1093/molbev/msu265
Appears in Collections:
Articles; Red Sea Research Center (RSRC)

Full metadata record

DC FieldValue Language
dc.contributor.authorGanot, P.en
dc.contributor.authorZoccola, D.en
dc.contributor.authorTambutte, E.en
dc.contributor.authorVoolstra, Christian R.en
dc.contributor.authorAranda, Manuelen
dc.contributor.authorAllemand, D.en
dc.contributor.authorTambutte, S.en
dc.date.accessioned2015-04-15T14:05:07Zen
dc.date.available2015-04-15T14:05:07Zen
dc.date.issued2014-09-21en
dc.identifier.citationStructural Molecular Components of Septate Junctions in Cnidarians Point to the Origin of Epithelial Junctions in Eukaryotes 2014, 32 (1):44 Molecular Biology and Evolutionen
dc.identifier.issn0737-4038en
dc.identifier.issn1537-1719en
dc.identifier.doi10.1093/molbev/msu265en
dc.identifier.urihttp://hdl.handle.net/10754/550141en
dc.description.abstractSeptate junctions (SJs) insure barrier properties and control paracellular diffusion of solutes across epithelia in invertebrates. However, the origin and evolution of their molecular constituents in Metazoa have not been firmly established. Here, we investigated the genomes of early branching metazoan representatives to reconstruct the phylogeny of the molecular components of SJs. Although Claudins and SJ cytoplasmic adaptor components appeared successively throughout metazoan evolution, the structural components of SJs arose at the time of Placozoa/Cnidaria/Bilateria radiation. We also show that in the scleractinian coral Stylophora pistillata, the structural SJ component Neurexin IV colocalizes with the cortical actin network at the apical border of the cells, at the place of SJs. We propose a model for SJ components in Cnidaria. Moreover, our study reveals an unanticipated diversity of SJ structural component variants in cnidarians. This diversity correlates with gene-specific expression in calcifying and noncalcifying tissues, suggesting specific paracellular pathways across the cell layers of these diploblastic animals.en
dc.publisherOxford University Press (OUP)en
dc.relation.urlhttp://mbe.oxfordjournals.org/cgi/doi/10.1093/molbev/msu265en
dc.rightsThis is a pre-copyedited, author-produced PDF of an article accepted for publication in MBE following peer review. The definitive publisher-authenticated version Ganot, Philippe, Didier Zoccola, Eric Tambutté, Christian R. Voolstra, Manuel Aranda, Denis Allemand, and Sylvie Tambutté. "Structural molecular components of Septate Junctions in cnidarians point to the origin of epithelial junctions in Eukaryotes." Molecular biology and evolution 32, no. 1 (2015): 44-62 is available online at http://mbe.oxfordjournals.org/content/32/1/44.en
dc.subjectEpitheliozoaen
dc.subjectClaudinen
dc.subjectNeurexinen
dc.subjectContactinen
dc.subjectNeuroglianen
dc.subjectCoracleen
dc.subjectMAGUKen
dc.subjectNa+/K+ ATPase transporteren
dc.subjectDSCAMen
dc.subjectNbl4en
dc.subjectpara-cellular pathwayen
dc.subjectpermselectivityen
dc.subjectcoralsen
dc.subjectctenophoresen
dc.subjectporiferansen
dc.subjectMonosigaen
dc.subjectCapsasporaen
dc.titleStructural Molecular Components of Septate Junctions in Cnidarians Point to the Origin of Epithelial Junctions in Eukaryotesen
dc.typeArticleen
dc.contributor.departmentRed Sea Research Center (RSRC)en
dc.identifier.journalMolecular Biology and Evolutionen
dc.eprint.versionPost-printen
dc.contributor.institutionMarine Biology Department, Centre Scientifique de Monaco, Quai Antoine Premier, Monacoen
kaust.authorVoolstra, Christian R.en
kaust.authorAranda, Manuelen
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