The Cytotoxic Effect of Small and Large Molecules of PMF Fraction Extracted from Camel Urine on Cancer Cells

Handle URI:
http://hdl.handle.net/10754/550090
Title:
The Cytotoxic Effect of Small and Large Molecules of PMF Fraction Extracted from Camel Urine on Cancer Cells
Authors:
Khorshid, Faten; Emwas, Abdul-Hamid M.; Mahboub, Faiza
Abstract:
Aim of the work: Animal urine, including that of camels, has long been used for the therapeutic management of human ailments. In this study, we sought to characterize the cytotoxic properties of newly derived purified fractions from previously described camel urine extract (PMF) on various cancer cell lines. Methodology: Two new size dissimilar fractions of PMF (large and small) were obtained by fractionalizing PMF using 3kD and 50kD membrane filters. A SRB cytotoxicity assay of the PMF fractions was performed on cancer cell lines (A549, HCT116, HepG2, MCF-7, U251 and Hela) as well as normal cell lines (human fibroblast cell line and Vero). Results: This study showed that the newly derived and more purified fraction of PMF (new PMF) possesses effective and selective anti-cancer properties against several types of cancer cell lines. Conclusion: This study, as well as previous ones, suggests that camel urine extracts (old and new PMF) may provide newer therapeutic alternatives to clinically manage cancer patients. However, further studies are needed to verify these positive preliminary results.
KAUST Department:
Advanced Nanofabrication, Imaging and Characterization Core Lab
Citation:
The Cytotoxic Effect of Small and Large Molecules of PMF Fraction Extracted from Camel Urine on Cancer Cells 2015, 6 (4):384 British Journal of Medicine and Medical Research
Publisher:
Sciencedomain International
Journal:
British Journal of Medicine and Medical Research
Issue Date:
10-Jan-2015
DOI:
10.9734/BJMMR/2015/12271
Type:
Article
ISSN:
22310614
Additional Links:
http://www.sciencedomain.org/abstract.php?iid=723&id=12&aid=7351
Appears in Collections:
Articles; Advanced Nanofabrication, Imaging and Characterization Core Lab

Full metadata record

DC FieldValue Language
dc.contributor.authorKhorshid, Fatenen
dc.contributor.authorEmwas, Abdul-Hamid M.en
dc.contributor.authorMahboub, Faizaen
dc.date.accessioned2015-04-14T13:04:35Zen
dc.date.available2015-04-14T13:04:35Zen
dc.date.issued2015-01-10en
dc.identifier.citationThe Cytotoxic Effect of Small and Large Molecules of PMF Fraction Extracted from Camel Urine on Cancer Cells 2015, 6 (4):384 British Journal of Medicine and Medical Researchen
dc.identifier.issn22310614en
dc.identifier.doi10.9734/BJMMR/2015/12271en
dc.identifier.urihttp://hdl.handle.net/10754/550090en
dc.description.abstractAim of the work: Animal urine, including that of camels, has long been used for the therapeutic management of human ailments. In this study, we sought to characterize the cytotoxic properties of newly derived purified fractions from previously described camel urine extract (PMF) on various cancer cell lines. Methodology: Two new size dissimilar fractions of PMF (large and small) were obtained by fractionalizing PMF using 3kD and 50kD membrane filters. A SRB cytotoxicity assay of the PMF fractions was performed on cancer cell lines (A549, HCT116, HepG2, MCF-7, U251 and Hela) as well as normal cell lines (human fibroblast cell line and Vero). Results: This study showed that the newly derived and more purified fraction of PMF (new PMF) possesses effective and selective anti-cancer properties against several types of cancer cell lines. Conclusion: This study, as well as previous ones, suggests that camel urine extracts (old and new PMF) may provide newer therapeutic alternatives to clinically manage cancer patients. However, further studies are needed to verify these positive preliminary results.en
dc.publisherSciencedomain Internationalen
dc.relation.urlhttp://www.sciencedomain.org/abstract.php?iid=723&id=12&aid=7351en
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.titleThe Cytotoxic Effect of Small and Large Molecules of PMF Fraction Extracted from Camel Urine on Cancer Cellsen
dc.typeArticleen
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Laben
dc.identifier.journalBritish Journal of Medicine and Medical Researchen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionBiology Department, Faculty of Applied Science, Umm Al-Qura University, Makah Al-Mukaramah, Saudi Arabiaen
dc.contributor.institutionDepartment of Biology, Faculty of Science, King Abdulaziz University (KAU), Saudi Arabiaen
kaust.authorEmwas, Abdul-Hamid M.en
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