The role of ontologies in biological and biomedical research: a functional perspective

Handle URI:
http://hdl.handle.net/10754/543733
Title:
The role of ontologies in biological and biomedical research: a functional perspective
Authors:
Hoehndorf, Robert ( 0000-0001-8149-5890 ) ; Schofield, P. N.; Gkoutos, G. V.
Abstract:
Ontologies are widely used in biological and biomedical research. Their success lies in their combination of four main features present in almost all ontologies: provision of standard identifiers for classes and relations that represent the phenomena within a domain; provision of a vocabulary for a domain; provision of metadata that describes the intended meaning of the classes and relations in ontologies; and the provision of machine-readable axioms and definitions that enable computational access to some aspects of the meaning of classes and relations. While each of these features enables applications that facilitate data integration, data access and analysis, a great potential lies in the possibility of combining these four features to support integrative analysis and interpretation of multimodal data. Here, we provide a functional perspective on ontologies in biology and biomedicine, focusing on what ontologies can do and describing how they can be used in support of integrative research. We also outline perspectives for using ontologies in data-driven science, in particular their application in structured data mining and machine learning applications.
KAUST Department:
Computational Bioscience Research Center (CBRC)
Citation:
The role of ontologies in biological and biomedical research: a functional perspective 2015 Briefings in Bioinformatics
Journal:
Briefings in Bioinformatics
Issue Date:
10-Apr-2015
DOI:
10.1093/bib/bbv011
Type:
Article
ISSN:
1467-5463; 1477-4054
Additional Links:
http://bib.oxfordjournals.org/cgi/doi/10.1093/bib/bbv011
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC)

Full metadata record

DC FieldValue Language
dc.contributor.authorHoehndorf, Roberten
dc.contributor.authorSchofield, P. N.en
dc.contributor.authorGkoutos, G. V.en
dc.date.accessioned2015-04-14T07:58:36Zen
dc.date.available2015-04-14T07:58:36Zen
dc.date.issued2015-04-10en
dc.identifier.citationThe role of ontologies in biological and biomedical research: a functional perspective 2015 Briefings in Bioinformaticsen
dc.identifier.issn1467-5463en
dc.identifier.issn1477-4054en
dc.identifier.doi10.1093/bib/bbv011en
dc.identifier.urihttp://hdl.handle.net/10754/543733en
dc.description.abstractOntologies are widely used in biological and biomedical research. Their success lies in their combination of four main features present in almost all ontologies: provision of standard identifiers for classes and relations that represent the phenomena within a domain; provision of a vocabulary for a domain; provision of metadata that describes the intended meaning of the classes and relations in ontologies; and the provision of machine-readable axioms and definitions that enable computational access to some aspects of the meaning of classes and relations. While each of these features enables applications that facilitate data integration, data access and analysis, a great potential lies in the possibility of combining these four features to support integrative analysis and interpretation of multimodal data. Here, we provide a functional perspective on ontologies in biology and biomedicine, focusing on what ontologies can do and describing how they can be used in support of integrative research. We also outline perspectives for using ontologies in data-driven science, in particular their application in structured data mining and machine learning applications.en
dc.relation.urlhttp://bib.oxfordjournals.org/cgi/doi/10.1093/bib/bbv011en
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.titleThe role of ontologies in biological and biomedical research: a functional perspectiveen
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalBriefings in Bioinformaticsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionBiomedical Informatics at the University of Cambridgeen
dc.contributor.institutionBioinformatics at the University of Aberystwythen
kaust.authorHoehndorf, Roberten
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