Functionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)responsive Coating and their Application in Hyperthermia and Heat-Triggered Drug Delivery

Handle URI:
http://hdl.handle.net/10754/350276
Title:
Functionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)responsive Coating and their Application in Hyperthermia and Heat-Triggered Drug Delivery
Authors:
Kakwere, Hamilton; Pernia Leal, Manuel; Materia, Maria-Elena; Curcio, Alberto; Guardia, Pablo; Niculaes, Dina; Marotta, Roberto; Falqui, Andrea ( 0000-0002-1476-7742 ) ; Pellegrino, Teresa
Abstract:
Herein we prepare nanohybrids by incorporating iron oxide nanocubes (cubic-IONPs) within a thermo-responsive polymer shell that can act as drug carriers for doxorubicin(doxo). The cubic-shaped nanoparticles employed are at the interface between superparamagnetic and ferromagnetic behavior and have an exceptionally high specific absorption rate (SAR) but their functionalization is extremely challenging compared to bare superparamagnetic iron oxide nanoparticles as they strongly interact with each other. By conducting the polymer grafting reaction using reversible addition-fragmentation chain transfer (RAFT) polymerization in a viscous solvent medium, we have here developed a facile approach to decorate the nanocubes with stimuli-responsive polymers. When the thermo-responsive shell is composed of poly(N-isopropyl acrylamide-co-polyethylene glycolmethylether acrylate), nanohybrids have a phase transition temperature, the lower critical solution temperature (LCST), above 37 °C in physiological conditions. Doxo loaded nanohybrids exhibited a negligible drug release below 37 °C but showed a consistent release of their cargo on demand by exploiting the capability of the nanocubes to generate heat under an alternating magnetic field (AMF). Moreover, the drug free nanocarrier does not exhibit cytotoxicity even when administered at high concentration of nanocubes (1g/L of iron) and internalized at high extent (260 pg of iron per cell). We have also implemented the synthesis protocol to decorate the surface of nanocubes with poly(vinylpyridine) polymer and thus prepare pH-responsive shell coated nanocubes.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Functionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)responsive Coating and their Application in Hyperthermia and Heat-Triggered Drug Delivery 2015:150403101542007 ACS Applied Materials & Interfaces
Publisher:
American Chemical Society
Journal:
ACS Applied Materials & Interfaces
Issue Date:
3-Apr-2015
DOI:
10.1021/am5088117
Type:
Article
ISSN:
1944-8244; 1944-8252
Additional Links:
http://pubs.acs.org/doi/abs/10.1021/am5088117
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorKakwere, Hamiltonen
dc.contributor.authorPernia Leal, Manuelen
dc.contributor.authorMateria, Maria-Elenaen
dc.contributor.authorCurcio, Albertoen
dc.contributor.authorGuardia, Pabloen
dc.contributor.authorNiculaes, Dinaen
dc.contributor.authorMarotta, Robertoen
dc.contributor.authorFalqui, Andreaen
dc.contributor.authorPellegrino, Teresaen
dc.date.accessioned2015-04-08T12:30:44Zen
dc.date.available2015-04-08T12:30:44Zen
dc.date.issued2015-04-03en
dc.identifier.citationFunctionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)responsive Coating and their Application in Hyperthermia and Heat-Triggered Drug Delivery 2015:150403101542007 ACS Applied Materials & Interfacesen
dc.identifier.issn1944-8244en
dc.identifier.issn1944-8252en
dc.identifier.doi10.1021/am5088117en
dc.identifier.urihttp://hdl.handle.net/10754/350276en
dc.description.abstractHerein we prepare nanohybrids by incorporating iron oxide nanocubes (cubic-IONPs) within a thermo-responsive polymer shell that can act as drug carriers for doxorubicin(doxo). The cubic-shaped nanoparticles employed are at the interface between superparamagnetic and ferromagnetic behavior and have an exceptionally high specific absorption rate (SAR) but their functionalization is extremely challenging compared to bare superparamagnetic iron oxide nanoparticles as they strongly interact with each other. By conducting the polymer grafting reaction using reversible addition-fragmentation chain transfer (RAFT) polymerization in a viscous solvent medium, we have here developed a facile approach to decorate the nanocubes with stimuli-responsive polymers. When the thermo-responsive shell is composed of poly(N-isopropyl acrylamide-co-polyethylene glycolmethylether acrylate), nanohybrids have a phase transition temperature, the lower critical solution temperature (LCST), above 37 °C in physiological conditions. Doxo loaded nanohybrids exhibited a negligible drug release below 37 °C but showed a consistent release of their cargo on demand by exploiting the capability of the nanocubes to generate heat under an alternating magnetic field (AMF). Moreover, the drug free nanocarrier does not exhibit cytotoxicity even when administered at high concentration of nanocubes (1g/L of iron) and internalized at high extent (260 pg of iron per cell). We have also implemented the synthesis protocol to decorate the surface of nanocubes with poly(vinylpyridine) polymer and thus prepare pH-responsive shell coated nanocubes.en
dc.publisherAmerican Chemical Societyen
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/am5088117en
dc.rightsArchived with thanks to ACS Applied Materials & Interfacesen
dc.titleFunctionalization of Strongly Interacting Magnetic Nanocubes with (Thermo)responsive Coating and their Application in Hyperthermia and Heat-Triggered Drug Deliveryen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalACS Applied Materials & Interfacesen
dc.eprint.versionPost-printen
dc.contributor.institutionIstituto Italiano di Tecnologia, via Morego 30, 16143, Genova, Italyen
kaust.authorFalqui, Andreaen
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