Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands

Handle URI:
http://hdl.handle.net/10754/348543
Title:
Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands
Authors:
Altaf, Muhammad; Monim-ul-Mehboob, M.; Seliman, Adam A.A.; Sohail, Manzar; Wazeer, Mohammed I.M.; Isab, Anvarhusein A.; Li, L.; Dhuna, V.; Bhatia, G.; Dhuna, K.
Abstract:
Two new gold(I) complexes that contain tri-ter-butylphosphine and dialkyl dithiocarbamate ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic voltammetry, elemental analysis and X-ray diffraction. The in vitro cytotoxicity of both complexes was examined against A549 (lung cancer), MCF7 (breast cancer), and HeLa (cervical cancer) human cancer cell lines. Both complexes exhibit very strong in vitro cytotoxic effects against A549, MCF7 and HeLa cell lines. The screening of the cytotoxic activity based on IC50 data against the A549, MCF7, and HeLa lines shows that the synthesized gold(I) complexes are highly effective, particularly against HeLa cancer cell line. Based on IC50 data, the cytotoxic activity of both complexes is better than well-known commercial anticancer drug cisplatin against all the three cancer lines tested.
KAUST Department:
King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900 Jeddah, Saudi Arabia
Citation:
Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands 2015 European Journal of Medicinal Chemistry
Publisher:
Elsevier
Journal:
European Journal of Medicinal Chemistry
Issue Date:
10-Mar-2015
DOI:
10.1016/j.ejmech.2015.03.019
Type:
Article
ISSN:
02235234
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0223523415001865
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorAltaf, Muhammaden
dc.contributor.authorMonim-ul-Mehboob, M.en
dc.contributor.authorSeliman, Adam A.A.en
dc.contributor.authorSohail, Manzaren
dc.contributor.authorWazeer, Mohammed I.M.en
dc.contributor.authorIsab, Anvarhusein A.en
dc.contributor.authorLi, L.en
dc.contributor.authorDhuna, V.en
dc.contributor.authorBhatia, G.en
dc.contributor.authorDhuna, K.en
dc.date.accessioned2015-04-06T09:18:03Zen
dc.date.available2015-04-06T09:18:03Zen
dc.date.issued2015-03-10en
dc.identifier.citationSynthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands 2015 European Journal of Medicinal Chemistryen
dc.identifier.issn02235234en
dc.identifier.doi10.1016/j.ejmech.2015.03.019en
dc.identifier.urihttp://hdl.handle.net/10754/348543en
dc.description.abstractTwo new gold(I) complexes that contain tri-ter-butylphosphine and dialkyl dithiocarbamate ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic voltammetry, elemental analysis and X-ray diffraction. The in vitro cytotoxicity of both complexes was examined against A549 (lung cancer), MCF7 (breast cancer), and HeLa (cervical cancer) human cancer cell lines. Both complexes exhibit very strong in vitro cytotoxic effects against A549, MCF7 and HeLa cell lines. The screening of the cytotoxic activity based on IC50 data against the A549, MCF7, and HeLa lines shows that the synthesized gold(I) complexes are highly effective, particularly against HeLa cancer cell line. Based on IC50 data, the cytotoxic activity of both complexes is better than well-known commercial anticancer drug cisplatin against all the three cancer lines tested.en
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0223523415001865en
dc.rightsArchived with thanks to European Journal of Medicinal Chemistry. Copyright © 2015 Published by Elsevier Masson SASen
dc.titleSynthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligandsen
dc.typeArticleen
dc.contributor.departmentKing Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900 Jeddah, Saudi Arabiaen
dc.identifier.journalEuropean Journal of Medicinal Chemistryen
dc.eprint.versionPost-printen
dc.contributor.institutionDepartment of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabiaen
dc.contributor.institutionCenter of Excellence in Nanotechnology, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabiaen
dc.contributor.institutionDept. of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, Indiaen
dc.contributor.institutionDepartment of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, Indiaen
kaust.authorLi, L.en
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