Genomic analysis of the causative agents of coccidiosis in domestic chickens

Handle URI:
http://hdl.handle.net/10754/346998
Title:
Genomic analysis of the causative agents of coccidiosis in domestic chickens
Authors:
Reid, Adam J.; Blake, Damer P.; Ansari, Hifzur R.; Billington, Karen; Browne, Hilary P.; Bryant, Josephine; Dunn, Matt; Hung, Stacy S.; Kawahara, Fumiya; Miranda-Saavedra, Diego; Malas, Tareq B.; Mourier, Tobias; Naghra, Hardeep; Nair, Mridul; Otto, Thomas D.; Rawlings, Neil D.; Rivailler, Pierre; Sanchez-Flores, Alejandro; Sanders, Mandy; Subramaniam, Chandra; Tay, Yea-Ling; Woo, Yong; Wu, Xikun; Barrell, Bart; Dear, Paul H.; Doerig, Christian; Gruber, Arthur; Ivens, Alasdair C.; Parkinson, John; Rajandream, Marie-Adèle; Shirley, Martin W.; Wan, Kiew-Lian; Berriman, Matthew; Tomley, Fiona M.; Pain, Arnab ( 0000-0002-1755-2819 )
Abstract:
Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.
KAUST Department:
Computational Bioscience Research Center (CBRC)
Citation:
Genomic analysis of the causative agents of coccidiosis in domestic chickens 2014, 24 (10):1676 Genome Research
Publisher:
Cold Spring Harbor Laboratory Press
Journal:
Genome Research
Issue Date:
Oct-2014
DOI:
10.1101/gr.168955.113
PubMed ID:
25015382
PubMed Central ID:
PMC4199364
Type:
Article
ISSN:
1088-9051; 1549-5469
Additional Links:
http://genome.cshlp.org/lookup/doi/10.1101/gr.168955.113
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC)

Full metadata record

DC FieldValue Language
dc.contributor.authorReid, Adam J.en
dc.contributor.authorBlake, Damer P.en
dc.contributor.authorAnsari, Hifzur R.en
dc.contributor.authorBillington, Karenen
dc.contributor.authorBrowne, Hilary P.en
dc.contributor.authorBryant, Josephineen
dc.contributor.authorDunn, Matten
dc.contributor.authorHung, Stacy S.en
dc.contributor.authorKawahara, Fumiyaen
dc.contributor.authorMiranda-Saavedra, Diegoen
dc.contributor.authorMalas, Tareq B.en
dc.contributor.authorMourier, Tobiasen
dc.contributor.authorNaghra, Hardeepen
dc.contributor.authorNair, Mridulen
dc.contributor.authorOtto, Thomas D.en
dc.contributor.authorRawlings, Neil D.en
dc.contributor.authorRivailler, Pierreen
dc.contributor.authorSanchez-Flores, Alejandroen
dc.contributor.authorSanders, Mandyen
dc.contributor.authorSubramaniam, Chandraen
dc.contributor.authorTay, Yea-Lingen
dc.contributor.authorWoo, Yongen
dc.contributor.authorWu, Xikunen
dc.contributor.authorBarrell, Barten
dc.contributor.authorDear, Paul H.en
dc.contributor.authorDoerig, Christianen
dc.contributor.authorGruber, Arthuren
dc.contributor.authorIvens, Alasdair C.en
dc.contributor.authorParkinson, Johnen
dc.contributor.authorRajandream, Marie-Adèleen
dc.contributor.authorShirley, Martin W.en
dc.contributor.authorWan, Kiew-Lianen
dc.contributor.authorBerriman, Matthewen
dc.contributor.authorTomley, Fiona M.en
dc.contributor.authorPain, Arnaben
dc.date.accessioned2015-03-23T08:20:42Zen
dc.date.available2015-03-23T08:20:42Zen
dc.date.issued2014-10en
dc.identifier.citationGenomic analysis of the causative agents of coccidiosis in domestic chickens 2014, 24 (10):1676 Genome Researchen
dc.identifier.issn1088-9051en
dc.identifier.issn1549-5469en
dc.identifier.pmid25015382en
dc.identifier.doi10.1101/gr.168955.113en
dc.identifier.urihttp://hdl.handle.net/10754/346998en
dc.description.abstractGlobal production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.en
dc.publisherCold Spring Harbor Laboratory Pressen
dc.relation.urlhttp://genome.cshlp.org/lookup/doi/10.1101/gr.168955.113en
dc.rightsThis article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.en
dc.titleGenomic analysis of the causative agents of coccidiosis in domestic chickensen
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalGenome Researchen
dc.identifier.pmcidPMC4199364en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionWellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdomen
dc.contributor.institutionRoyal Veterinary College, North Mymms, Hertfordshire AL9 7TA, United Kingdomen
dc.contributor.institutionThe Pirbright Institute, Compton Laboratory, Newbury, Berkshire RG20 7NN, United Kingdomen
dc.contributor.institutionProgram in Molecular Structure and Function, Hospital for Sick Children and Departments of Biochemistry and Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canadaen
dc.contributor.institutionNippon Institute for Biological Science, Ome, Tokyo 198-0024, Japanen
dc.contributor.institutionFibrosis Laboratories, Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdomen
dc.contributor.institutionCentre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, 1350 Copenhagen, Denmarken
dc.contributor.institutionSchool of Life Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdomen
dc.contributor.institutionEuropean Bioinformatics Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdomen
dc.contributor.institutionDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USAen
dc.contributor.institutionUnidad Universitaria de Apoyo Bioinformático, Institute of Biotechnology, Universidad Nacional Autónoma de México, Cuernavaca, Morelos 62210, Mexicoen
dc.contributor.institutionSchool of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor DE, Malaysiaen
dc.contributor.institutionMalaysia Genome Institute, Jalan Bangi, 43000 Kajang, Selangor DE, Malaysiaen
dc.contributor.institutionAmgen Limited, Uxbridge UB8 1DH, United Kingdomen
dc.contributor.institutionMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdomen
dc.contributor.institutionDepartment of Microbiology, Monash University, Clayton VIC 3800, Australiaen
dc.contributor.institutionDepartament of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazilen
dc.contributor.institutionCentre for Immunity, Infection and Evolution, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdomen
dc.contributor.institutionThe Pirbright Institute, Pirbright Laboratory, Pirbright, Surrey GU24 0NF, United Kingdomen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorAnsari, Hifzur Rahmanen
kaust.authorMalas, Tareq Majed Yasinen
kaust.authorNair, Mridulen
kaust.authorWoo, Yongen
kaust.authorPain, Arnaben

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