Non-chemotoxic induction of cancer cell death using magnetic nanowires

Handle URI:
http://hdl.handle.net/10754/346981
Title:
Non-chemotoxic induction of cancer cell death using magnetic nanowires
Authors:
Contreras, Maria F. ( 0000-0001-6239-5325 ) ; Sougrat, Rachid; Zaher, Amir Omar; Ravasi, Timothy ( 0000-0002-9950-465X ) ; Kosel, Jürgen ( 0000-0002-8998-8275 )
Abstract:
In this paper, we show that magnetic nanowires with weak magnetic fields and low frequencies can induce cell death via a mechanism that does not involve heat production. We incubated colon cancer cells with two concentrations (2.4 and 12 μg/mL) of nickel nanowires that were 35 nm in diameter and exposed the cells and nanowires to an alternating magnetic field (0.5 mT and 1 Hz or 1 kHz) for 10 or 30 minutes. This low-power field exerted a force on the magnetic nanowires, causing a mechanical disturbance to the cells. Transmission electron microscopy images showed that the nanostructures were internalized into the cells within 1 hour of incubation. Cell viability studies showed that the magnetic field and the nanowires separately had minor deleterious effects on the cells; however, when combined, the magnetic field and nanowires caused the cell viability values to drop by up to 39%, depending on the strength of the magnetic field and the concentration of the nanowires. Cell membrane leakage experiments indicated membrane leakage of 20%, suggesting that cell death mechanisms induced by the nanowires and magnetic field involve some cell membrane rupture. Results suggest that magnetic nanowires can kill cancer cells. The proposed process requires simple and low-cost equipment with exposure to only very weak magnetic fields for short time periods. © 2015 Contreras et al.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Advanced Nanofabrication, Imaging and Characterization Core Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Citation:
Non-chemotoxic induction of cancer cell death using magnetic nanowires 2015:2141 International Journal of Nanomedicine
Publisher:
Dove Medical Press Ltd.
Journal:
International Journal of Nanomedicine
Issue Date:
Mar-2015
DOI:
10.2147/IJN.S77081
PubMed ID:
25834430
PubMed Central ID:
PMC4370947
Type:
Article
ISSN:
1178-2013
Additional Links:
http://www.dovepress.com/non-chemotoxic-induction-of-cancer-cell-death-using-magnetic-nanowires-peer-reviewed-article-IJN; https://youtu.be/mYNeEfAOu0M
Appears in Collections:
Articles; Advanced Nanofabrication, Imaging and Characterization Core Lab; Biological and Environmental Sciences and Engineering (BESE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorContreras, Maria F.en
dc.contributor.authorSougrat, Rachiden
dc.contributor.authorZaher, Amir Omaren
dc.contributor.authorRavasi, Timothyen
dc.contributor.authorKosel, Jürgenen
dc.date.accessioned2015-03-23T08:19:38Zen
dc.date.available2015-03-23T08:19:38Zen
dc.date.issued2015-03en
dc.identifier.citationNon-chemotoxic induction of cancer cell death using magnetic nanowires 2015:2141 International Journal of Nanomedicineen
dc.identifier.issn1178-2013en
dc.identifier.pmid25834430en
dc.identifier.doi10.2147/IJN.S77081en
dc.identifier.urihttp://hdl.handle.net/10754/346981en
dc.description.abstractIn this paper, we show that magnetic nanowires with weak magnetic fields and low frequencies can induce cell death via a mechanism that does not involve heat production. We incubated colon cancer cells with two concentrations (2.4 and 12 μg/mL) of nickel nanowires that were 35 nm in diameter and exposed the cells and nanowires to an alternating magnetic field (0.5 mT and 1 Hz or 1 kHz) for 10 or 30 minutes. This low-power field exerted a force on the magnetic nanowires, causing a mechanical disturbance to the cells. Transmission electron microscopy images showed that the nanostructures were internalized into the cells within 1 hour of incubation. Cell viability studies showed that the magnetic field and the nanowires separately had minor deleterious effects on the cells; however, when combined, the magnetic field and nanowires caused the cell viability values to drop by up to 39%, depending on the strength of the magnetic field and the concentration of the nanowires. Cell membrane leakage experiments indicated membrane leakage of 20%, suggesting that cell death mechanisms induced by the nanowires and magnetic field involve some cell membrane rupture. Results suggest that magnetic nanowires can kill cancer cells. The proposed process requires simple and low-cost equipment with exposure to only very weak magnetic fields for short time periods. © 2015 Contreras et al.en
dc.publisherDove Medical Press Ltd.en
dc.relation.urlhttp://www.dovepress.com/non-chemotoxic-induction-of-cancer-cell-death-using-magnetic-nanowires-peer-reviewed-article-IJNen
dc.relation.urlhttps://youtu.be/mYNeEfAOu0Men
dc.rightsThis work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.phpen
dc.titleNon-chemotoxic induction of cancer cell death using magnetic nanowiresen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Laben
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.identifier.journalInternational Journal of Nanomedicineen
dc.identifier.pmcidPMC4370947en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorSougrat, Rachiden
kaust.authorRavasi, Timothyen
kaust.authorKosel, Jürgenen
kaust.authorContreras, Maria F.en
kaust.authorZaher, Amir Omaren

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