Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures

Handle URI:
http://hdl.handle.net/10754/346796
Title:
Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures
Authors:
Zhang, Ye; Zhou, Ning; Shi, Junfeng; Pochapsky, Susan Sondej; Pochapsky, Thomas C.; Zhang, Bei; Zhang, Xixiang ( 0000-0002-3478-6414 ) ; Xu, Bing
Abstract:
While used extensively by nature to control the geometry of protein structures, and dynamics of proteins, such as self-organization, hydration forces and ionic interactions received less attention for controlling the behaviour of small molecules. Here we describe the synthesis and characterization of a novel zwitterionic metallopeptide consisting of a cationic core and three distal anionic groups linked by self-assembling peptide motifs. 2D NMR spectra, total correlated spectroscopy and nuclear Overhauser effect spectroscopy, show that the molecule exhibits a three-fold rotational symmetry and adopts a folded conformation in dimethyl sulfoxide due to Coulombic forces. When hydrated in water, the molecule unfolds to act as a self-assembling building block of supramolecular nanostructures. By combining ionic interactions with the unique geometry from metal complex and hydrophobic interactions from simple peptides, we demonstrate a new and effective way to design molecules for smart materials through mimicking a sophisticated biofunctional system using a conformational switch.
KAUST Department:
Nano-fabrication, Imaging & Characterization Core Lab
Citation:
Unfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures 2015, 6:6165 Nature Communications
Publisher:
Nature Publishing Group
Journal:
Nature Communications
Issue Date:
19-Feb-2015
DOI:
10.1038/ncomms7165
Type:
Article
ISSN:
2041-1723
Additional Links:
http://www.nature.com/doifinder/10.1038/ncomms7165
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorZhang, Yeen
dc.contributor.authorZhou, Ningen
dc.contributor.authorShi, Junfengen
dc.contributor.authorPochapsky, Susan Sondejen
dc.contributor.authorPochapsky, Thomas C.en
dc.contributor.authorZhang, Beien
dc.contributor.authorZhang, Xixiangen
dc.contributor.authorXu, Bingen
dc.date.accessioned2015-03-17T13:42:42Zen
dc.date.available2015-03-17T13:42:42Zen
dc.date.issued2015-02-19en
dc.identifier.citationUnfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructures 2015, 6:6165 Nature Communicationsen
dc.identifier.issn2041-1723en
dc.identifier.doi10.1038/ncomms7165en
dc.identifier.urihttp://hdl.handle.net/10754/346796en
dc.description.abstractWhile used extensively by nature to control the geometry of protein structures, and dynamics of proteins, such as self-organization, hydration forces and ionic interactions received less attention for controlling the behaviour of small molecules. Here we describe the synthesis and characterization of a novel zwitterionic metallopeptide consisting of a cationic core and three distal anionic groups linked by self-assembling peptide motifs. 2D NMR spectra, total correlated spectroscopy and nuclear Overhauser effect spectroscopy, show that the molecule exhibits a three-fold rotational symmetry and adopts a folded conformation in dimethyl sulfoxide due to Coulombic forces. When hydrated in water, the molecule unfolds to act as a self-assembling building block of supramolecular nanostructures. By combining ionic interactions with the unique geometry from metal complex and hydrophobic interactions from simple peptides, we demonstrate a new and effective way to design molecules for smart materials through mimicking a sophisticated biofunctional system using a conformational switch.en
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://www.nature.com/doifinder/10.1038/ncomms7165en
dc.rightsArchived with thanks to Nature Communicationsen
dc.titleUnfolding a molecular trefoil derived from a zwitterionic metallopeptide to form self-assembled nanostructuresen
dc.typeArticleen
dc.contributor.departmentNano-fabrication, Imaging & Characterization Core Laben
dc.identifier.journalNature Communicationsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454, USAen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorZhang, Beien
kaust.authorZhang, Xixiangen
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