To die or not to die? Lessons from lesion mimic mutants

Handle URI:
http://hdl.handle.net/10754/346613
Title:
To die or not to die? Lessons from lesion mimic mutants
Authors:
Bruggeman, Quentin; Raynaud, Cécile; Benhamed, Moussa ( 0000-0002-4181-1702 ) ; Delarue, Marianne
Abstract:
Programmed cell death (PCD) is a ubiquitous genetically regulated process consisting in an activation of finely controlled signaling pathways that lead to cellular suicide. Although some aspects of PCD control appear evolutionary conserved between plants, animals and fungi, the extent of conservation remains controversial. Over the last decades, identification and characterization of several lesion mimic mutants (LMM) has been a powerful tool in the quest to unravel PCD pathways in plants. Thanks to progress in molecular genetics, mutations causing the phenotype of a large number of LMM and their related suppressors were mapped, and the identification of the mutated genes shed light on major pathways in the onset of plant PCD such as (i) the involvements of chloroplasts and light energy, (ii) the roles of sphingolipids and fatty acids, (iii) a signal perception at the plasma membrane that requires efficient membrane trafficking, (iv) secondary messengers such as ion fluxes and ROS and (v) the control of gene expression as the last integrator of the signaling pathways.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
To die or not to die? Lessons from lesion mimic mutants 2015, 6 Frontiers in Plant Science
Publisher:
Frontiers Media SA
Journal:
Frontiers in Plant Science
Issue Date:
30-Jan-2015
DOI:
10.3389/fpls.2015.00024
PubMed ID:
25688254
PubMed Central ID:
PMC4311611
Type:
Article
ISSN:
1664-462X
Additional Links:
http://journal.frontiersin.org/article/10.3389/fpls.2015.00024/abstract
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorBruggeman, Quentinen
dc.contributor.authorRaynaud, Cécileen
dc.contributor.authorBenhamed, Moussaen
dc.contributor.authorDelarue, Marianneen
dc.date.accessioned2015-03-15T14:07:52Zen
dc.date.available2015-03-15T14:07:52Zen
dc.date.issued2015-01-30en
dc.identifier.citationTo die or not to die? Lessons from lesion mimic mutants 2015, 6 Frontiers in Plant Scienceen
dc.identifier.issn1664-462Xen
dc.identifier.pmid25688254en
dc.identifier.doi10.3389/fpls.2015.00024en
dc.identifier.urihttp://hdl.handle.net/10754/346613en
dc.description.abstractProgrammed cell death (PCD) is a ubiquitous genetically regulated process consisting in an activation of finely controlled signaling pathways that lead to cellular suicide. Although some aspects of PCD control appear evolutionary conserved between plants, animals and fungi, the extent of conservation remains controversial. Over the last decades, identification and characterization of several lesion mimic mutants (LMM) has been a powerful tool in the quest to unravel PCD pathways in plants. Thanks to progress in molecular genetics, mutations causing the phenotype of a large number of LMM and their related suppressors were mapped, and the identification of the mutated genes shed light on major pathways in the onset of plant PCD such as (i) the involvements of chloroplasts and light energy, (ii) the roles of sphingolipids and fatty acids, (iii) a signal perception at the plasma membrane that requires efficient membrane trafficking, (iv) secondary messengers such as ion fluxes and ROS and (v) the control of gene expression as the last integrator of the signaling pathways.en
dc.publisherFrontiers Media SAen
dc.relation.urlhttp://journal.frontiersin.org/article/10.3389/fpls.2015.00024/abstracten
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.titleTo die or not to die? Lessons from lesion mimic mutantsen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalFrontiers in Plant Scienceen
dc.identifier.pmcidPMC4311611en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorBenhamed, Moussaen

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