Glycogen metabolism and the homeostatic regulation of sleep

Handle URI:
http://hdl.handle.net/10754/337010
Title:
Glycogen metabolism and the homeostatic regulation of sleep
Authors:
Petit, Jean-Marie; Burlet-Godinot, Sophie; Magistretti, Pierre J. ( 0000-0002-6678-320X ) ; Allaman, Igor
Abstract:
In 1995 Benington and Heller formulated an energy hypothesis of sleep centered on a key role of glycogen. It was postulated that a major function of sleep is to replenish glycogen stores in the brain that have been depleted during wakefulness which is associated to an increased energy demand. Astrocytic glycogen depletion participates to an increase of extracellular adenosine release which influences sleep homeostasis. Here, we will review some evidence obtained by studies addressing the question of a key role played by glycogen metabolism in sleep regulation as proposed by this hypothesis or by an alternative hypothesis named “glycogenetic” hypothesis as well as the importance of the confounding effect of glucocorticoïds. Even though actual collected data argue in favor of a role of sleep in brain energy balance-homeostasis, they do not support a critical and direct involvement of glycogen metabolism on sleep regulation. For instance, glycogen levels during the sleep-wake cycle are driven by different physiological signals and therefore appear more as a marker-integrator of brain energy status than a direct regulator of sleep homeostasis. In support of this we provide evidence that blockade of glycogen mobilization does not induce more sleep episodes during the active period while locomotor activity is reduced. These observations do not invalidate the energy hypothesis of sleep but indicate that underlying cellular mechanisms are more complex than postulated by Benington and Heller.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Glycogen metabolism and the homeostatic regulation of sleep 2014 Metabolic Brain Disease
Publisher:
Springer
Journal:
Metabolic Brain Disease
Issue Date:
16-Nov-2014
DOI:
10.1007/s11011-014-9629-x
Type:
Article
ISSN:
0885-7490; 1573-7365
Sponsors:
This work was supported by grants from Swiss National Science Foundation (FNRS) (no. 310030B-148169/1), from the NCCR Synapsy and from the Biaggi and Panacée Foundations to P.J.M.
Additional Links:
http://link.springer.com/10.1007/s11011-014-9629-x
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorPetit, Jean-Marieen
dc.contributor.authorBurlet-Godinot, Sophieen
dc.contributor.authorMagistretti, Pierre J.en
dc.contributor.authorAllaman, Igoren
dc.date.accessioned2014-12-10T06:46:35Zen
dc.date.available2014-12-10T06:46:35Zen
dc.date.issued2014-11-16en
dc.identifier.citationGlycogen metabolism and the homeostatic regulation of sleep 2014 Metabolic Brain Diseaseen
dc.identifier.issn0885-7490en
dc.identifier.issn1573-7365en
dc.identifier.doi10.1007/s11011-014-9629-xen
dc.identifier.urihttp://hdl.handle.net/10754/337010en
dc.description.abstractIn 1995 Benington and Heller formulated an energy hypothesis of sleep centered on a key role of glycogen. It was postulated that a major function of sleep is to replenish glycogen stores in the brain that have been depleted during wakefulness which is associated to an increased energy demand. Astrocytic glycogen depletion participates to an increase of extracellular adenosine release which influences sleep homeostasis. Here, we will review some evidence obtained by studies addressing the question of a key role played by glycogen metabolism in sleep regulation as proposed by this hypothesis or by an alternative hypothesis named “glycogenetic” hypothesis as well as the importance of the confounding effect of glucocorticoïds. Even though actual collected data argue in favor of a role of sleep in brain energy balance-homeostasis, they do not support a critical and direct involvement of glycogen metabolism on sleep regulation. For instance, glycogen levels during the sleep-wake cycle are driven by different physiological signals and therefore appear more as a marker-integrator of brain energy status than a direct regulator of sleep homeostasis. In support of this we provide evidence that blockade of glycogen mobilization does not induce more sleep episodes during the active period while locomotor activity is reduced. These observations do not invalidate the energy hypothesis of sleep but indicate that underlying cellular mechanisms are more complex than postulated by Benington and Heller.en
dc.description.sponsorshipThis work was supported by grants from Swiss National Science Foundation (FNRS) (no. 310030B-148169/1), from the NCCR Synapsy and from the Biaggi and Panacée Foundations to P.J.M.en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttp://link.springer.com/10.1007/s11011-014-9629-xen
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.en
dc.subjectGliaen
dc.subjectPTGen
dc.subjectGlucocorticoïdsen
dc.subjectEnergy metabolismen
dc.subjectNoradrenalineen
dc.subjectBrainen
dc.titleGlycogen metabolism and the homeostatic regulation of sleepen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalMetabolic Brain Diseaseen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionCenter for Psychiatric Neuroscience, Department of Psychiatry, CHUV, 1008, Prilly, Switzerlanden
dc.contributor.institutionLaboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerlanden
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorMagistretti, Pierre J.en
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