Period doubling induced by thermal noise amplification in genetic circuits

Handle URI:
http://hdl.handle.net/10754/337009
Title:
Period doubling induced by thermal noise amplification in genetic circuits
Authors:
Ruocco, G.; Fratalocchi, Andrea ( 0000-0001-6769-4439 )
Abstract:
Rhythms of life are dictated by oscillations, which take place in a wide rage of biological scales. In bacteria, for example, oscillations have been proven to control many fundamental processes, ranging from gene expression to cell divisions. In genetic circuits, oscillations originate from elemental block such as autorepressors and toggle switches, which produce robust and noise-free cycles with well defined frequency. In some circumstances, the oscillation period of biological functions may double, thus generating bistable behaviors whose ultimate origin is at the basis of intense investigations. Motivated by brain studies, we here study an “elemental” genetic circuit, where a simple nonlinear process interacts with a noisy environment. In the proposed system, nonlinearity naturally arises from the mechanism of cooperative stability, which regulates the concentration of a protein produced during a transcription process. In this elemental model, bistability results from the coherent amplification of environmental fluctuations due to a stochastic resonance of nonlinear origin. This suggests that the period doubling observed in many biological functions might result from the intrinsic interplay between nonlinearity and thermal noise.
KAUST Department:
PRIMALIGHT Research Group; Electrical Engineering Program; Applied Mathematics and Computational Science Program
Citation:
Period doubling induced by thermal noise amplification in genetic circuits 2014, 4:7088 Scientific Reports
Publisher:
Nature Publishing Group
Journal:
Scientific Reports
Issue Date:
18-Nov-2014
DOI:
10.1038/srep07088
Type:
Article
ISSN:
2045-2322
Sponsors:
A. Fratalocchi acknowledges funding from KAUST (Award No. CRG-1-2012- FRA-005). For parallel computing, this research used the resources of the Primalight group at KAUST University.
Additional Links:
http://www.nature.com/doifinder/10.1038/srep07088
Appears in Collections:
Articles; Applied Mathematics and Computational Science Program; PRIMALIGHT Research Group; Electrical Engineering Program

Full metadata record

DC FieldValue Language
dc.contributor.authorRuocco, G.en
dc.contributor.authorFratalocchi, Andreaen
dc.date.accessioned2014-12-10T06:33:54Z-
dc.date.available2014-12-10T06:33:54Z-
dc.date.issued2014-11-18en
dc.identifier.citationPeriod doubling induced by thermal noise amplification in genetic circuits 2014, 4:7088 Scientific Reportsen
dc.identifier.issn2045-2322en
dc.identifier.doi10.1038/srep07088en
dc.identifier.urihttp://hdl.handle.net/10754/337009en
dc.description.abstractRhythms of life are dictated by oscillations, which take place in a wide rage of biological scales. In bacteria, for example, oscillations have been proven to control many fundamental processes, ranging from gene expression to cell divisions. In genetic circuits, oscillations originate from elemental block such as autorepressors and toggle switches, which produce robust and noise-free cycles with well defined frequency. In some circumstances, the oscillation period of biological functions may double, thus generating bistable behaviors whose ultimate origin is at the basis of intense investigations. Motivated by brain studies, we here study an “elemental” genetic circuit, where a simple nonlinear process interacts with a noisy environment. In the proposed system, nonlinearity naturally arises from the mechanism of cooperative stability, which regulates the concentration of a protein produced during a transcription process. In this elemental model, bistability results from the coherent amplification of environmental fluctuations due to a stochastic resonance of nonlinear origin. This suggests that the period doubling observed in many biological functions might result from the intrinsic interplay between nonlinearity and thermal noise.en
dc.description.sponsorshipA. Fratalocchi acknowledges funding from KAUST (Award No. CRG-1-2012- FRA-005). For parallel computing, this research used the resources of the Primalight group at KAUST University.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://www.nature.com/doifinder/10.1038/srep07088en
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.subjectBiophysicsen
dc.subjectPhysicsen
dc.titlePeriod doubling induced by thermal noise amplification in genetic circuitsen
dc.typeArticleen
dc.contributor.departmentPRIMALIGHT Research Groupen
dc.contributor.departmentElectrical Engineering Programen
dc.contributor.departmentApplied Mathematics and Computational Science Programen
dc.identifier.journalScientific Reportsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionSapienza University of Rome, Department of Physics, Piazzale Aldo Moro 5, 00185 Rome, Italyen
dc.contributor.institutionCenter for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161, Rome, Italyen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorFratalocchi, Andreaen
kaust.authorRuocco, Giancarloen
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