Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts

Handle URI:
http://hdl.handle.net/10754/336097
Title:
Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts
Authors:
Otto, Thomas D.; Rayner, Julian C.; Böhme, Ulrike; Pain, Arnab ( 0000-0002-1755-2819 ) ; Spottiswoode, Natasha; Sanders, Mandy; Quail, Michael; Ollomo, Benjamin; Renaud, François; Thomas, Alan W.; Prugnolle, Franck; Conway, David J.; Newbold, Chris; Berriman, Matthew
Abstract:
Plasmodium falciparum causes most human malaria deaths, having prehistorically evolved from parasites of African Great Apes. Here we explore the genomic basis of P. falciparum adaptation to human hosts by fully sequencing the genome of the closely related chimpanzee parasite species P. reichenowi, and obtaining partial sequence data from a more distantly related chimpanzee parasite (P. gaboni). The close relationship between P. reichenowi and P. falciparum is emphasized by almost complete conservation of genomic synteny, but against this strikingly conserved background we observe major differences at loci involved in erythrocyte invasion. The organization of most virulence-associated multigene families, including the hypervariable var genes, is broadly conserved, but P. falciparum has a smaller subset of rif and stevor genes whose products are expressed on the infected erythrocyte surface. Genome-wide analysis identifies other loci under recent positive selection, but a limited number of changes at the host–parasite interface may have mediated host switching.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Computational Bioscience Research Center (CBRC)
Citation:
Otto, T. D., Rayner, J. C., Böhme, U., Pain, A., Spottiswoode, N., Sanders, M., . . . Berriman, M. (2014). Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts. Nat Commun, 5. doi: 10.1038/ncomms5754
Publisher:
Springer Nature
Journal:
Nature Communications
Issue Date:
9-Sep-2014
DOI:
10.1038/ncomms5754
PubMed ID:
25203297
PubMed Central ID:
PMC4166903
Type:
Article
ISSN:
2041-1723
Sponsors:
This work was supported by the Wellcome Trust (grant number WT 098051) with additional funding to T.D.O. from the European Community’s Seventh Framework Programme (FP7/2007-2013), under grant agreement number 242095; J.C.R., from the National Institutes of Health (R01 AI091595); B.O. from Centre International de Recherches Médicales de Franceville; F.R. and F.P., from CNRS and IRD; F.R., B.O. and F.P. from the Agence Nationale de la Recherche (grant ANR JCJC SVSE 7-2012 ORIGIN); D.J.C. from an ERC Advanced Award (grant number 294428); and C.N. from the Wellcome Trust (grant number WT 082130/Z/07/Z).
Additional Links:
http://www.nature.com/doifinder/10.1038/ncomms5754
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC); Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorOtto, Thomas D.en
dc.contributor.authorRayner, Julian C.en
dc.contributor.authorBöhme, Ulrikeen
dc.contributor.authorPain, Arnaben
dc.contributor.authorSpottiswoode, Natashaen
dc.contributor.authorSanders, Mandyen
dc.contributor.authorQuail, Michaelen
dc.contributor.authorOllomo, Benjaminen
dc.contributor.authorRenaud, Françoisen
dc.contributor.authorThomas, Alan W.en
dc.contributor.authorPrugnolle, Francken
dc.contributor.authorConway, David J.en
dc.contributor.authorNewbold, Chrisen
dc.contributor.authorBerriman, Matthewen
dc.date.accessioned2014-11-25T13:59:42Z-
dc.date.available2014-11-25T13:59:42Z-
dc.date.issued2014-09-09en
dc.identifier.citationOtto, T. D., Rayner, J. C., Böhme, U., Pain, A., Spottiswoode, N., Sanders, M., . . . Berriman, M. (2014). Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts. Nat Commun, 5. doi: 10.1038/ncomms5754en
dc.identifier.issn2041-1723en
dc.identifier.pmid25203297en
dc.identifier.doi10.1038/ncomms5754en
dc.identifier.urihttp://hdl.handle.net/10754/336097en
dc.description.abstractPlasmodium falciparum causes most human malaria deaths, having prehistorically evolved from parasites of African Great Apes. Here we explore the genomic basis of P. falciparum adaptation to human hosts by fully sequencing the genome of the closely related chimpanzee parasite species P. reichenowi, and obtaining partial sequence data from a more distantly related chimpanzee parasite (P. gaboni). The close relationship between P. reichenowi and P. falciparum is emphasized by almost complete conservation of genomic synteny, but against this strikingly conserved background we observe major differences at loci involved in erythrocyte invasion. The organization of most virulence-associated multigene families, including the hypervariable var genes, is broadly conserved, but P. falciparum has a smaller subset of rif and stevor genes whose products are expressed on the infected erythrocyte surface. Genome-wide analysis identifies other loci under recent positive selection, but a limited number of changes at the host–parasite interface may have mediated host switching.en
dc.description.sponsorshipThis work was supported by the Wellcome Trust (grant number WT 098051) with additional funding to T.D.O. from the European Community’s Seventh Framework Programme (FP7/2007-2013), under grant agreement number 242095; J.C.R., from the National Institutes of Health (R01 AI091595); B.O. from Centre International de Recherches Médicales de Franceville; F.R. and F.P., from CNRS and IRD; F.R., B.O. and F.P. from the Agence Nationale de la Recherche (grant ANR JCJC SVSE 7-2012 ORIGIN); D.J.C. from an ERC Advanced Award (grant number 294428); and C.N. from the Wellcome Trust (grant number WT 082130/Z/07/Z).en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.relation.urlhttp://www.nature.com/doifinder/10.1038/ncomms5754en
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/en
dc.titleGenome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hostsen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalNature Communicationsen
dc.identifier.pmcidPMC4166903en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionParasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UKen
dc.contributor.institutionNational Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USAen
dc.contributor.institutionWeatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UKen
dc.contributor.institutionCentre International de Recherches Médicales de Franceville, CIRMF, BP 769 Franceville, Gabonen
dc.contributor.institutionLaboratoire MIVEGEC, UMR 5290 CNRS-IRD-UMI-UMII, IRD, BP 64501, 34394 Montpellier, Franceen
dc.contributor.institutionBiomedical Primate Research Centre, Department of Parasitology, 2280 GH Rijswijk, The Netherlandsen
dc.contributor.institutionDepartment of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UKen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorPain, Arnaben

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