Stimuli-Responsive Liposomes for Controlled Drug Delivery

Handle URI:
http://hdl.handle.net/10754/335801
Title:
Stimuli-Responsive Liposomes for Controlled Drug Delivery
Authors:
Li, Wengang ( 0000-0002-1838-8360 )
Abstract:
Liposomes are promising drug delivery vesicles due to their biodegradibility, large volume and biocompatibility towards both hydrophilic and hydrophobic drugs. They suffer, however, from poor stability which limits their use in controlled delivery applications. Herein, a novel method was devised for modification of liposomes with small molecules, polymers or nanoparticles to afford stimuli responsive systems that release on demand and stay relatively stable in the absence of the trigger.. This dissertation discusses thermosensitive, pH sensitive, light sensitive and magnetically triggered liposomes that have been prepared for controlled drug delivery application. RAFT polymerization was utilized for the preparation of thermosensitive liposomes (Cholesterol-PNIPAm) and acid-labile liposomes (DOPE-PAA). With low Mw Cholesterol-PNIPAm, the thermosensitive liposomes proved to be effective for controlled release and decreased the cytotoxicity of PNIPAm by eliciting the polymer doses. By crosslinking the DOPE-PAA on liposome surface with acid-labile diamine linkers, DOPE-PAA liposomes were verified to be sensitive at low pH. The effects of polymer structures (linear or hyperbranched) have also been studied for the stability and release properties of liposomes. Finally, a dual-responsive Au@SPIO embedded liposome hybrid (ALHs) was prepared with light-induced “on-and-off” function by photo-thermal process (visible light) and instant release properties triggered by alternating magnetic field, respectively. The ALH system would be further applied into the cellular imaging field as MRI contrast agent.
Advisors:
Khashab, Niveen ( 0000-0003-2728-0666 )
Committee Member:
Takanabe, Kazuhiro ( 0000-0001-5374-9451 ) ; Han, Yu ( 0000-0003-1462-1118 ) ; Wang, Peng ( 0000-0003-0856-0865 )
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Program:
Chemical Sciences
Issue Date:
Sep-2014
Type:
Dissertation
Appears in Collections:
Dissertations; Physical Sciences and Engineering (PSE) Division; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.advisorKhashab, Niveenen
dc.contributor.authorLi, Wengangen
dc.date.accessioned2014-11-19T11:51:21Z-
dc.date.available2014-11-19T11:51:21Z-
dc.date.issued2014-09en
dc.identifier.urihttp://hdl.handle.net/10754/335801en
dc.description.abstractLiposomes are promising drug delivery vesicles due to their biodegradibility, large volume and biocompatibility towards both hydrophilic and hydrophobic drugs. They suffer, however, from poor stability which limits their use in controlled delivery applications. Herein, a novel method was devised for modification of liposomes with small molecules, polymers or nanoparticles to afford stimuli responsive systems that release on demand and stay relatively stable in the absence of the trigger.. This dissertation discusses thermosensitive, pH sensitive, light sensitive and magnetically triggered liposomes that have been prepared for controlled drug delivery application. RAFT polymerization was utilized for the preparation of thermosensitive liposomes (Cholesterol-PNIPAm) and acid-labile liposomes (DOPE-PAA). With low Mw Cholesterol-PNIPAm, the thermosensitive liposomes proved to be effective for controlled release and decreased the cytotoxicity of PNIPAm by eliciting the polymer doses. By crosslinking the DOPE-PAA on liposome surface with acid-labile diamine linkers, DOPE-PAA liposomes were verified to be sensitive at low pH. The effects of polymer structures (linear or hyperbranched) have also been studied for the stability and release properties of liposomes. Finally, a dual-responsive Au@SPIO embedded liposome hybrid (ALHs) was prepared with light-induced “on-and-off” function by photo-thermal process (visible light) and instant release properties triggered by alternating magnetic field, respectively. The ALH system would be further applied into the cellular imaging field as MRI contrast agent.en
dc.language.isoenen
dc.subjectLiposomesen
dc.subjectdrug deliveryen
dc.subjectstimuli responsiveen
dc.subjectlipid polymeren
dc.titleStimuli-Responsive Liposomes for Controlled Drug Deliveryen
dc.typeDissertationen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
thesis.degree.grantorKing Abdullah University of Science and Technologyen_GB
dc.contributor.committeememberTakanabe, Kazuhiroen
dc.contributor.committeememberHan, Yuen
dc.contributor.committeememberWang, Pengen
thesis.degree.disciplineChemical Sciencesen
thesis.degree.nameDoctor of Philosophyen
dc.person.id101989en
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