Proteomics insights: proteins related to larval attachment and metamorphosis of marine invertebrates

Handle URI:
http://hdl.handle.net/10754/334953
Title:
Proteomics insights: proteins related to larval attachment and metamorphosis of marine invertebrates
Authors:
Chandramouli, Kondethimmanahalli ( 0000-0002-0104-1993 ) ; Qian, Pei-Yuan; Ravasi, Timothy ( 0000-0002-9950-465X )
Abstract:
The transition in an animal from a pelagic larval stage to a sessile benthic juvenile typically requires major morphological and behavioral changes. Larval competency, attachment and initiation of metamorphosis are thought to be regulated by intrinsic chemical signals and specific sets of proteins. However, the molecular mechanisms that regulate larval attachment and metamorphosis in marine invertebrates have yet to be fully elucidated. Despite the many challenges associated with analysis of the larvae proteome, recent proteomic technologies have been used to address specific questions in larval developmental biology. These and other molecular studies have generated substantial amount of information of the proteins and molecular pathways involved in larval attachment and metamorphosis. Furthermore, the results of these studies have shown that systematic changes in protein expression patterns and post-translational modifications (PTMs) are crucial for the transition from larva to juvenile. The degeneration of larval tissues is mediated by protein degradation, while the development of juvenile organs may require PTM. In terms of application, the identified proteins may serve as targets for antifouling compounds, and biomarkers for environmental stressors. In this review we highlight the strengths and limitations of proteomic tools in the context of the study of marine invertebrate larval biology.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Applied Mathematics and Computational Science Program; Computer Science Program; KAUST Global Collaborative Research Program; Integrative Systems Biology Lab
Citation:
Chandramouli KH, Qian P-Y and Ravasi T (2014) Proteomics insights: proteins related to larval attachment and metamorphosis of marine invertebrates. Front. Mar. Sci. 1:52. doi: 10.3389/fmars.2014.00052
Publisher:
Frontiers Media SA
Journal:
Frontiers in Marine Science
Issue Date:
31-Oct-2014
DOI:
10.3389/fmars.2014.00052
Type:
Article
ISSN:
2296-7745
Sponsors:
This study was supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region (662413) and an award from King Abdullah University of Science and Technology (SA-C0040/ UK-C0016).
Additional Links:
http://journal.frontiersin.org/journal/10.3389/fmars.2014.00052/full
Appears in Collections:
Articles; Applied Mathematics and Computational Science Program; Computer Science Program; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorChandramouli, Kondethimmanahallien
dc.contributor.authorQian, Pei-Yuanen
dc.contributor.authorRavasi, Timothyen
dc.date.accessioned2014-11-16T12:31:19Z-
dc.date.available2014-11-16T12:31:19Z-
dc.date.issued2014-10-31en
dc.identifier.citationChandramouli KH, Qian P-Y and Ravasi T (2014) Proteomics insights: proteins related to larval attachment and metamorphosis of marine invertebrates. Front. Mar. Sci. 1:52. doi: 10.3389/fmars.2014.00052en
dc.identifier.issn2296-7745en
dc.identifier.doi10.3389/fmars.2014.00052en
dc.identifier.urihttp://hdl.handle.net/10754/334953en
dc.description.abstractThe transition in an animal from a pelagic larval stage to a sessile benthic juvenile typically requires major morphological and behavioral changes. Larval competency, attachment and initiation of metamorphosis are thought to be regulated by intrinsic chemical signals and specific sets of proteins. However, the molecular mechanisms that regulate larval attachment and metamorphosis in marine invertebrates have yet to be fully elucidated. Despite the many challenges associated with analysis of the larvae proteome, recent proteomic technologies have been used to address specific questions in larval developmental biology. These and other molecular studies have generated substantial amount of information of the proteins and molecular pathways involved in larval attachment and metamorphosis. Furthermore, the results of these studies have shown that systematic changes in protein expression patterns and post-translational modifications (PTMs) are crucial for the transition from larva to juvenile. The degeneration of larval tissues is mediated by protein degradation, while the development of juvenile organs may require PTM. In terms of application, the identified proteins may serve as targets for antifouling compounds, and biomarkers for environmental stressors. In this review we highlight the strengths and limitations of proteomic tools in the context of the study of marine invertebrate larval biology.en
dc.description.sponsorshipThis study was supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region (662413) and an award from King Abdullah University of Science and Technology (SA-C0040/ UK-C0016).en
dc.language.isoenen
dc.publisherFrontiers Media SAen
dc.relation.urlhttp://journal.frontiersin.org/journal/10.3389/fmars.2014.00052/fullen
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.subjectmarine invertebratesen
dc.subjectlarvae metamorphosisen
dc.subjectbiofoulingen
dc.subjectproteomicsen
dc.subjectpost-translational modificationsen
dc.titleProteomics insights: proteins related to larval attachment and metamorphosis of marine invertebratesen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentApplied Mathematics and Computational Science Programen
dc.contributor.departmentComputer Science Programen
dc.contributor.departmentKAUST Global Collaborative Research Programen
dc.contributor.departmentIntegrative Systems Biology Laben
dc.identifier.journalFrontiers in Marine Scienceen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDivision of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kongen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorChandramouli, Kondethimmanahallien
kaust.authorRavasi, Timothyen
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