Simple and reusable picoinjector for liquid delivery via nanofluidics approach

Handle URI:
http://hdl.handle.net/10754/334601
Title:
Simple and reusable picoinjector for liquid delivery via nanofluidics approach
Authors:
Li, Shunbo; Cao, Wenbin; Hui, Yu Sanna; Wen, Weijia
Abstract:
Precise control of sample volume is one of the most important functions in lab-on-a-chip (LOC) systems, especially for chemical and biological reactions. The common approach used for liquid delivery involves the employment of capillaries and microstructures for generating a droplet which has a volume in the nanoliter or picoliter range. Here, we report a novel approach for constructing a picoinjector which is based on well-controlled electroosmotic (EO) flow to electrokinetically drive sample solutions. This picoinjector comprises an array of interconnected nanochannels for liquid delivery. Such technique for liquid delivery has the advantages of well-controlled sample volume and reusable nanofluidic chip, and it was reported for the first time. In the study of the pumping process for this picoinjector, the EO flow rate was determined by the intensity of the fluorescent probe. The influence of ion concentration in electrolyte solutions over the EO flow rate was also investigated and discussed. The application of this EO-driven picoinjector for chemical reactions was demonstrated by the reaction between Fluo-4 and calcium chloride with the reaction cycle controlled by the applied square waves of different duty cycles. The precision of our device can reach down to picoliter per second, which is much smaller than that of most existing technologies. This new approach, thus, opens further possibilities of adopting nanofluidics for well-controlled chemical reactions with particular applications in nanoparticle synthesis, bimolecular synthesis, drug delivery, and diagnostic testing.
KAUST Department:
Department of Physics and Joint KAUST-HKUST Micro/Nano-Fluidics Laboratory, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
Citation:
Li S, Cao W, Hui Y, Wen W (2014) Simple and reusable picoinjector for liquid delivery via nanofluidics approach. Nanoscale Research Letters 9: 147. doi:10.1186/1556-276X-9-147.
Publisher:
Springer
Journal:
Nanoscale Research Letters
Issue Date:
25-Mar-2014
DOI:
10.1186/1556-276X-9-147
PubMed ID:
24666418
PubMed Central ID:
PMC3987644
Type:
Article
ISSN:
1931-7573
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Shunboen
dc.contributor.authorCao, Wenbinen
dc.contributor.authorHui, Yu Sannaen
dc.contributor.authorWen, Weijiaen
dc.date.accessioned2014-11-11T14:31:35Z-
dc.date.available2014-11-11T14:31:35Z-
dc.date.issued2014-03-25en
dc.identifier.citationLi S, Cao W, Hui Y, Wen W (2014) Simple and reusable picoinjector for liquid delivery via nanofluidics approach. Nanoscale Research Letters 9: 147. doi:10.1186/1556-276X-9-147.en
dc.identifier.issn1931-7573en
dc.identifier.pmid24666418en
dc.identifier.doi10.1186/1556-276X-9-147en
dc.identifier.urihttp://hdl.handle.net/10754/334601en
dc.description.abstractPrecise control of sample volume is one of the most important functions in lab-on-a-chip (LOC) systems, especially for chemical and biological reactions. The common approach used for liquid delivery involves the employment of capillaries and microstructures for generating a droplet which has a volume in the nanoliter or picoliter range. Here, we report a novel approach for constructing a picoinjector which is based on well-controlled electroosmotic (EO) flow to electrokinetically drive sample solutions. This picoinjector comprises an array of interconnected nanochannels for liquid delivery. Such technique for liquid delivery has the advantages of well-controlled sample volume and reusable nanofluidic chip, and it was reported for the first time. In the study of the pumping process for this picoinjector, the EO flow rate was determined by the intensity of the fluorescent probe. The influence of ion concentration in electrolyte solutions over the EO flow rate was also investigated and discussed. The application of this EO-driven picoinjector for chemical reactions was demonstrated by the reaction between Fluo-4 and calcium chloride with the reaction cycle controlled by the applied square waves of different duty cycles. The precision of our device can reach down to picoliter per second, which is much smaller than that of most existing technologies. This new approach, thus, opens further possibilities of adopting nanofluidics for well-controlled chemical reactions with particular applications in nanoparticle synthesis, bimolecular synthesis, drug delivery, and diagnostic testing.en
dc.language.isoenen
dc.publisherSpringeren
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleSimple and reusable picoinjector for liquid delivery via nanofluidics approachen
dc.typeArticleen
dc.contributor.departmentDepartment of Physics and Joint KAUST-HKUST Micro/Nano-Fluidics Laboratory, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kongen
dc.identifier.journalNanoscale Research Lettersen
dc.identifier.pmcidPMC3987644en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionNano Science and Technology Program and Department of Physics, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kongen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorLi, Shunboen
kaust.authorWen, Weijiaen

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