Dopamine receptor genes and evolutionary differentiation in the domestication of fighting cocks and long-crowing chickens

Handle URI:
http://hdl.handle.net/10754/334560
Title:
Dopamine receptor genes and evolutionary differentiation in the domestication of fighting cocks and long-crowing chickens
Authors:
Komiyama, Tomoyoshi; Iwama, Hisakazu; Osada, Naoki; Nakamura, Yoji; Kobayashi, Hiroyuki; Tateno, Yoshio; Gojobori, Takashi ( 0000-0001-7850-1743 )
Abstract:
The chicken domestication process represents a typical model of artificial selection, and gives significant insight into the general understanding of the influence of artificial selection on recognizable phenotypes. Two Japanese domesticated chicken varieties, the fighting cock (Shamo) and the long-crowing chicken (Naganakidori), have been selectively bred for dramatically different phenotypes. The former has been selected exclusively for aggressiveness and the latter for long crowing with an obedient sitting posture. To understand the particular mechanism behind these genetic changes during domestication, we investigated the degree of genetic differentiation in the aforementioned chickens, focusing on dopamine receptor D2, D3, and D4 genes. We studied other ornamental chickens such as Chabo chickens as a reference for comparison. When genetic differentiation was measured by an index of nucleotide differentiation (NST) newly devised in this study, we found that the NST value of DRD4 for Shamo (0.072) was distinctively larger than those of the other genes among the three populations, suggesting that aggressiveness has been selected for in Shamo by collecting a variety of single nucleotide polymorphisms. In addition, we found that in DRD4 in Naganakidori, there is a deletion variant of one proline at the 24th residue in the repeat of nine prolines of exon 1. We thus conclude that artificial selection has operated on these different kinds of genetic variation in the DRD4 genes of Shamo and Naganakidori so strongly that the two domesticated varieties have differentiated to obtain their present opposite features in a relatively short period of time. © 2014 Komiyama et al.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Computational Bioscience Research Center (CBRC)
Citation:
Komiyama T, Iwama H, Osada N, Nakamura Y, Kobayashi H, et al. (2014) Dopamine Receptor Genes and Evolutionary Differentiation in the Domestication of Fighting Cocks and Long-Crowing Chickens. PLoS ONE 9: e101778. doi:10.1371/journal.pone.0101778.
Publisher:
Public Library of Science
Journal:
PLoS ONE
Issue Date:
31-Jul-2014
DOI:
10.1371/journal.pone.0101778
PubMed ID:
25078403
PubMed Central ID:
PMC4117491
Type:
Article
ISSN:
19326203
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC); Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorKomiyama, Tomoyoshien
dc.contributor.authorIwama, Hisakazuen
dc.contributor.authorOsada, Naokien
dc.contributor.authorNakamura, Yojien
dc.contributor.authorKobayashi, Hiroyukien
dc.contributor.authorTateno, Yoshioen
dc.contributor.authorGojobori, Takashien
dc.date.accessioned2014-11-11T14:29:38Z-
dc.date.available2014-11-11T14:29:38Z-
dc.date.issued2014-07-31en
dc.identifier.citationKomiyama T, Iwama H, Osada N, Nakamura Y, Kobayashi H, et al. (2014) Dopamine Receptor Genes and Evolutionary Differentiation in the Domestication of Fighting Cocks and Long-Crowing Chickens. PLoS ONE 9: e101778. doi:10.1371/journal.pone.0101778.en
dc.identifier.issn19326203en
dc.identifier.pmid25078403en
dc.identifier.doi10.1371/journal.pone.0101778en
dc.identifier.urihttp://hdl.handle.net/10754/334560en
dc.description.abstractThe chicken domestication process represents a typical model of artificial selection, and gives significant insight into the general understanding of the influence of artificial selection on recognizable phenotypes. Two Japanese domesticated chicken varieties, the fighting cock (Shamo) and the long-crowing chicken (Naganakidori), have been selectively bred for dramatically different phenotypes. The former has been selected exclusively for aggressiveness and the latter for long crowing with an obedient sitting posture. To understand the particular mechanism behind these genetic changes during domestication, we investigated the degree of genetic differentiation in the aforementioned chickens, focusing on dopamine receptor D2, D3, and D4 genes. We studied other ornamental chickens such as Chabo chickens as a reference for comparison. When genetic differentiation was measured by an index of nucleotide differentiation (NST) newly devised in this study, we found that the NST value of DRD4 for Shamo (0.072) was distinctively larger than those of the other genes among the three populations, suggesting that aggressiveness has been selected for in Shamo by collecting a variety of single nucleotide polymorphisms. In addition, we found that in DRD4 in Naganakidori, there is a deletion variant of one proline at the 24th residue in the repeat of nine prolines of exon 1. We thus conclude that artificial selection has operated on these different kinds of genetic variation in the DRD4 genes of Shamo and Naganakidori so strongly that the two domesticated varieties have differentiated to obtain their present opposite features in a relatively short period of time. © 2014 Komiyama et al.en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rightsArchived with thanks to PLoS ONEen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleDopamine receptor genes and evolutionary differentiation in the domestication of fighting cocks and long-crowing chickensen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalPLoS ONEen
dc.identifier.pmcidPMC4117491en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDepartment of Clinical Pharmacology, Tokai University School of Medicine, Shimokasuya, Isehara, Kanagawa, Japanen
dc.contributor.institutionKagawa University, Life Science Research Center, Kagawa, Japanen
dc.contributor.institutionNational Institute of Genetics, Shizuoka, Japanen
dc.contributor.institutionNational Research Institute of Fisheries Science, Fisheries Research Agency, Kanagawa, Japanen
dc.contributor.institutionSchool of New Biology, Daegu Gyoungbuk Institute of Science and Technology, Daegu, South Koreaen
dc.contributor.institutionSOKENDAI, Department of Genetics, Graduate School of Advanced Studies, Hayama, Kanagawa, Japanen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorGojobori, Takashien

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