The five Ws (and one H) of super-hydrophobic surfaces in medicine

Handle URI:
http://hdl.handle.net/10754/334548
Title:
The five Ws (and one H) of super-hydrophobic surfaces in medicine
Authors:
Gentile, F.; Coluccio, M.L.; Limongi, T.; Perozziello, G.; Candeloro, P.; Di, Fabrizio, E.
Abstract:
Super-hydrophobic surfaces (SHSs) are bio-inspired, artificial microfabricated interfaces, in which a pattern of cylindrical micropillars is modified to incorporate details at the nanoscale. For those systems, the integration of different scales translates into superior properties, including the ability of manipulating biological solutions. The five Ws, five Ws and one H or the six Ws (6W), are questions, whose answers are considered basic in information-gathering. They constitute a formula for getting the complete story on a subject. According to the principle of the six Ws, a report can only be considered complete if it answers these questions starting with an interrogative word: who, why, what, where, when, how. Each question should have a factual answer. In what follows, SHSs and some of the most promising applications thereof are reviewed following the scheme of the 6W. We will show how these surfaces can be integrated into bio-photonic devices for the identification and detection of a single molecule. We will describe how SHSs and nanoporous silicon matrices can be combined to yield devices with the capability of harvesting small molecules, where the cut-off size can be adequately controlled. We will describe how this concept is utilized for obtaining a direct TEM image of a DNA molecule. 2014 by the authors; licensee MDPI, Basel, Switzerland.
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Citation:
Gentile F, Coluccio M, Limongi T, Perozziello G, Candeloro P, et al. (2014) The Five Ws (and one H) of Super-Hydrophobic Surfaces in Medicine. Micromachines 5: 239-262. doi:10.3390/mi5020239.
Publisher:
MDPI AG
Journal:
Micromachines
Issue Date:
5-May-2014
DOI:
10.3390/mi5020239
Type:
Article
ISSN:
2072666X
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorGentile, F.en
dc.contributor.authorColuccio, M.L.en
dc.contributor.authorLimongi, T.en
dc.contributor.authorPerozziello, G.en
dc.contributor.authorCandeloro, P.en
dc.contributor.authorDi, Fabrizio, E.en
dc.date.accessioned2014-11-11T14:29:15Z-
dc.date.available2014-11-11T14:29:15Z-
dc.date.issued2014-05-05en
dc.identifier.citationGentile F, Coluccio M, Limongi T, Perozziello G, Candeloro P, et al. (2014) The Five Ws (and one H) of Super-Hydrophobic Surfaces in Medicine. Micromachines 5: 239-262. doi:10.3390/mi5020239.en
dc.identifier.issn2072666Xen
dc.identifier.doi10.3390/mi5020239en
dc.identifier.urihttp://hdl.handle.net/10754/334548en
dc.description.abstractSuper-hydrophobic surfaces (SHSs) are bio-inspired, artificial microfabricated interfaces, in which a pattern of cylindrical micropillars is modified to incorporate details at the nanoscale. For those systems, the integration of different scales translates into superior properties, including the ability of manipulating biological solutions. The five Ws, five Ws and one H or the six Ws (6W), are questions, whose answers are considered basic in information-gathering. They constitute a formula for getting the complete story on a subject. According to the principle of the six Ws, a report can only be considered complete if it answers these questions starting with an interrogative word: who, why, what, where, when, how. Each question should have a factual answer. In what follows, SHSs and some of the most promising applications thereof are reviewed following the scheme of the 6W. We will show how these surfaces can be integrated into bio-photonic devices for the identification and detection of a single molecule. We will describe how SHSs and nanoporous silicon matrices can be combined to yield devices with the capability of harvesting small molecules, where the cut-off size can be adequately controlled. We will describe how this concept is utilized for obtaining a direct TEM image of a DNA molecule. 2014 by the authors; licensee MDPI, Basel, Switzerland.en
dc.language.isoenen
dc.publisherMDPI AGen
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rightsArchived with thanks to Micromachinesen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectBiosensorsen
dc.subjectElectroless depositionen
dc.subjectNano-opticsen
dc.subjectNanoporous siliconen
dc.subjectNanosensorsen
dc.subjectSingle molecule detectionen
dc.subjectSuper-hydrophobic surfacesen
dc.subjectElectroless platingen
dc.subjectMoleculesen
dc.subjectSiliconen
dc.subjectSurface chemistryen
dc.subjectBiological solutionsen
dc.subjectMicrofabricateden
dc.subjectNano-porous siliconen
dc.subjectNanoopticsen
dc.subjectSingle moleculeen
dc.subjectSingle-molecule detectionen
dc.subjectSmall moleculesen
dc.subjectHydrophobicityen
dc.titleThe five Ws (and one H) of super-hydrophobic surfaces in medicineen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalMicromachinesen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionIstituto Italiano di Tecnologia, 16163 Genova, Italyen
dc.contributor.institutionDepartment of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italyen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorLimongi, Taniaen
kaust.authorDi Fabrizio, Enzo M.en
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