PH responsive self-assembly of cucurbit[7]urils and polystyrene-block- polyvinylpyridine micelles for hydrophobic drug delivery

Handle URI:
http://hdl.handle.net/10754/334525
Title:
PH responsive self-assembly of cucurbit[7]urils and polystyrene-block- polyvinylpyridine micelles for hydrophobic drug delivery
Authors:
Moosa, Basem ( 0000-0002-2350-4100 ) ; Mashat, A.; Li, W.; Fhayli, K.; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Polystyrene-block-polyvinylpyridine (PS-b-P4VP) polypseudorotaxanes with cucurbit[7]urils (CB[7]) were prepared from water soluble PS-b-P4VPH+ polymer and CB[7] in aqueous solution at room temperature. At acidic and neutral pH, the pyridinium block of PS-b-P4VP is protonated (PS-b-P4VPH +) pushing CB[7] to preferably host the P4VP block. At basic pH (pH 8), P4VP is not charged and thus is not able to strongly complex CB[7]. This phenomenon was verified further by monitoring the release of pyrene, a hydrophobic cargo model, from a PS-b-P4VPH+/CB[7] micellar membrane. Release study of UV active pyrene from the membrane at different pH values revealed that the system is only operational under basic conditions and that the host-guest interaction of CB[7] with P4VPH+ significantly slows down cargo release.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab
Citation:
Moosa BA, Mashat A, Li W, Fhayli K, Khashab NM (2013) pH Responsive Self-Assembly of Cucurbit[7]urils and Polystyrene-Block-Polyvinylpyridine Micelles for Hydrophobic Drug Delivery. Journal of Nanomaterials 2013: 1-6. doi:10.1155/2013/719168.
Publisher:
Hindawi Publishing Corporation
Journal:
Journal of Nanomaterials
Issue Date:
2013
DOI:
10.1155/2013/719168
Type:
Article
ISSN:
16874110
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Controlled Release and Delivery Laboratory

Full metadata record

DC FieldValue Language
dc.contributor.authorMoosa, Basemen
dc.contributor.authorMashat, A.en
dc.contributor.authorLi, W.en
dc.contributor.authorFhayli, K.en
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2014-11-11T14:28:24Z-
dc.date.available2014-11-11T14:28:24Z-
dc.date.issued2013en
dc.identifier.citationMoosa BA, Mashat A, Li W, Fhayli K, Khashab NM (2013) pH Responsive Self-Assembly of Cucurbit[7]urils and Polystyrene-Block-Polyvinylpyridine Micelles for Hydrophobic Drug Delivery. Journal of Nanomaterials 2013: 1-6. doi:10.1155/2013/719168.en
dc.identifier.issn16874110en
dc.identifier.doi10.1155/2013/719168en
dc.identifier.urihttp://hdl.handle.net/10754/334525en
dc.description.abstractPolystyrene-block-polyvinylpyridine (PS-b-P4VP) polypseudorotaxanes with cucurbit[7]urils (CB[7]) were prepared from water soluble PS-b-P4VPH+ polymer and CB[7] in aqueous solution at room temperature. At acidic and neutral pH, the pyridinium block of PS-b-P4VP is protonated (PS-b-P4VPH +) pushing CB[7] to preferably host the P4VP block. At basic pH (pH 8), P4VP is not charged and thus is not able to strongly complex CB[7]. This phenomenon was verified further by monitoring the release of pyrene, a hydrophobic cargo model, from a PS-b-P4VPH+/CB[7] micellar membrane. Release study of UV active pyrene from the membrane at different pH values revealed that the system is only operational under basic conditions and that the host-guest interaction of CB[7] with P4VPH+ significantly slows down cargo release.en
dc.language.isoenen
dc.publisherHindawi Publishing Corporationen
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rightsArchived with thanks to Journal of Nanomaterialsen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectBasic conditionsen
dc.subjectCargo releaseen
dc.subjectHost guest interactionsen
dc.subjectHydrophobic drug deliveryen
dc.subjectPH-responsiveen
dc.subjectPolypseudorotaxanesen
dc.subjectPolyvinylpyridineen
dc.subjectRoom temperatureen
dc.subjectDrug deliveryen
dc.subjectPolystyrenesen
dc.subjectPyreneen
dc.subjectHydrophobicityen
dc.titlePH responsive self-assembly of cucurbit[7]urils and polystyrene-block- polyvinylpyridine micelles for hydrophobic drug deliveryen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.identifier.journalJournal of Nanomaterialsen
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorMoosa, Basemen
kaust.authorMashat, Afnanen
kaust.authorLi, Wengangen
kaust.authorKhashab, Niveen M.en
kaust.authorFhayli, Karimen
This item is licensed under a Creative Commons License
Creative Commons
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.