Translational selection in human: More pronounced in housekeeping genes

Handle URI:
http://hdl.handle.net/10754/334485
Title:
Translational selection in human: More pronounced in housekeeping genes
Authors:
Ma, Lina; Cui, Peng; Zhu, Jiang; Zhang, Zhihua; Zhang, Zhang
Abstract:
Background: Translational selection is a ubiquitous and significant mechanism to regulate protein expression in prokaryotes and unicellular eukaryotes. Recent evidence has shown that translational selection is weakly operative in highly expressed genes in human and other vertebrates. However, it remains unclear whether translational selection acts differentially on human genes depending on their expression patterns.Results: Here we report that human housekeeping (HK) genes that are strictly defined as genes that are expressed ubiquitously and consistently in most or all tissues, are under stronger translational selection.Conclusions: These observations clearly show that translational selection is also closely associated with expression pattern. Our results suggest that human HK genes are more efficiently and/or accurately translated into proteins, which will inevitably open up a new understanding of HK genes and the regulation of gene expression.Reviewers: This article was reviewed by Yuan Yuan, Baylor College of Medicine; Han Liang, University of Texas MD Anderson Cancer Center (nominated by Dr Laura Landweber) Eugene Koonin, NCBI, NLM, NIH, United States of America Sandor Pongor, International Centre for Genetic Engineering and biotechnology (ICGEB), Italy. © 2014 Ma et al.; licensee BioMed Central Ltd.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Citation:
Ma L, Cui P, Zhu J, Zhang Z, Zhang Z (2014) Translational selection in human: more pronounced in housekeeping genes. Biology Direct 9: 17. doi:10.1186/1745-6150-9-17.
Publisher:
BioMed Central
Journal:
Biology Direct
Issue Date:
10-Jul-2014
DOI:
10.1186/1745-6150-9-17
PubMed ID:
25011537
PubMed Central ID:
PMC4100034
Type:
Article
ISSN:
17456150
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorMa, Linaen
dc.contributor.authorCui, Pengen
dc.contributor.authorZhu, Jiangen
dc.contributor.authorZhang, Zhihuaen
dc.contributor.authorZhang, Zhangen
dc.date.accessioned2014-11-11T14:27:31Z-
dc.date.available2014-11-11T14:27:31Z-
dc.date.issued2014-07-10en
dc.identifier.citationMa L, Cui P, Zhu J, Zhang Z, Zhang Z (2014) Translational selection in human: more pronounced in housekeeping genes. Biology Direct 9: 17. doi:10.1186/1745-6150-9-17.en
dc.identifier.issn17456150en
dc.identifier.pmid25011537en
dc.identifier.doi10.1186/1745-6150-9-17en
dc.identifier.urihttp://hdl.handle.net/10754/334485en
dc.description.abstractBackground: Translational selection is a ubiquitous and significant mechanism to regulate protein expression in prokaryotes and unicellular eukaryotes. Recent evidence has shown that translational selection is weakly operative in highly expressed genes in human and other vertebrates. However, it remains unclear whether translational selection acts differentially on human genes depending on their expression patterns.Results: Here we report that human housekeeping (HK) genes that are strictly defined as genes that are expressed ubiquitously and consistently in most or all tissues, are under stronger translational selection.Conclusions: These observations clearly show that translational selection is also closely associated with expression pattern. Our results suggest that human HK genes are more efficiently and/or accurately translated into proteins, which will inevitably open up a new understanding of HK genes and the regulation of gene expression.Reviewers: This article was reviewed by Yuan Yuan, Baylor College of Medicine; Han Liang, University of Texas MD Anderson Cancer Center (nominated by Dr Laura Landweber) Eugene Koonin, NCBI, NLM, NIH, United States of America Sandor Pongor, International Centre for Genetic Engineering and biotechnology (ICGEB), Italy. © 2014 Ma et al.; licensee BioMed Central Ltd.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en
dc.titleTranslational selection in human: More pronounced in housekeeping genesen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalBiology Directen
dc.identifier.pmcidPMC4100034en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionCAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.1 Beichen West Road, Chaoyang District, Beijing 100101, Chinaen
dc.contributor.institutionDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United Statesen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorCui, Pengen
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