Symbiotic adaptation drives genome streamlining of the cyanobacterial sponge symbiont "Candidatus Synechococcus pongiarum"

Handle URI:
http://hdl.handle.net/10754/325461
Title:
Symbiotic adaptation drives genome streamlining of the cyanobacterial sponge symbiont "Candidatus Synechococcus pongiarum"
Authors:
Gao, Zhao-Ming; Wang, Yong; Tian, Ren-Mao; Wong, Yue Him; Batang, Zenon B. ( 0000-0003-4593-0589 ) ; Al-Suwailem, Abdulaziz M.; Bajic, Vladimir B. ( 0000-0001-5435-4750 ) ; Qian, Pei-Yuan
Abstract:
"Candidatus Synechococcus spongiarum" is a cyanobacterial symbiont widely distributed in sponges, but its functions at the genome level remain unknown. Here, we obtained the draft genome (1.66 Mbp, 90% estimated genome recovery) of "Ca. Synechococcus spongiarum" strain SH4 inhabiting the Red Sea sponge Carteriospongia foliascens. Phylogenomic analysis revealed a high dissimilarity between SH4 and free-living cyanobacterial strains. Essential functions, such as photosynthesis, the citric acid cycle, and DNA replication, were detected in SH4. Eukaryoticlike domains that play important roles in sponge-symbiont interactions were identified exclusively in the symbiont. However, SH4 could not biosynthesize methionine and polyamines and had lost partial genes encoding low-molecular-weight peptides of the photosynthesis complex, antioxidant enzymes, DNA repair enzymes, and proteins involved in resistance to environmental toxins and in biosynthesis of capsular and extracellular polysaccharides. These genetic modifications imply that "Ca. Synechococcus spongiarum" SH4 represents a low-light-adapted cyanobacterial symbiont and has undergone genome streamlining to adapt to the sponge's mild intercellular environment. 2014 Gao et al.
KAUST Department:
Coastal and Marine Resources Core Lab; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Citation:
Gao Z-M, Wang Y, Tian R-M, Wong YH, Batang ZB, et al. (2014) Symbiotic Adaptation Drives Genome Streamlining of the Cyanobacterial Sponge Symbiont -Candidatus Synechococcus spongiarum.- mBio 5: e00079-14-e00079-14. doi:10.1128/mBio.00079-14.
Publisher:
American Society for Microbiology
Journal:
mBio
Issue Date:
1-Apr-2014
DOI:
10.1128/mBio.00079-14
PubMed ID:
24692632
PubMed Central ID:
PMC3977351
Type:
Article
ISSN:
21507511
Appears in Collections:
Articles; Coastal and Marine Resources Core Lab; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorGao, Zhao-Mingen
dc.contributor.authorWang, Yongen
dc.contributor.authorTian, Ren-Maoen
dc.contributor.authorWong, Yue Himen
dc.contributor.authorBatang, Zenon B.en
dc.contributor.authorAl-Suwailem, Abdulaziz M.en
dc.contributor.authorBajic, Vladimir B.en
dc.contributor.authorQian, Pei-Yuanen
dc.date.accessioned2014-08-27T09:52:22Z-
dc.date.available2014-08-27T09:52:22Z-
dc.date.issued2014-04-01en
dc.identifier.citationGao Z-M, Wang Y, Tian R-M, Wong YH, Batang ZB, et al. (2014) Symbiotic Adaptation Drives Genome Streamlining of the Cyanobacterial Sponge Symbiont -Candidatus Synechococcus spongiarum.- mBio 5: e00079-14-e00079-14. doi:10.1128/mBio.00079-14.en
dc.identifier.issn21507511en
dc.identifier.pmid24692632en
dc.identifier.doi10.1128/mBio.00079-14en
dc.identifier.urihttp://hdl.handle.net/10754/325461en
dc.description.abstract"Candidatus Synechococcus spongiarum" is a cyanobacterial symbiont widely distributed in sponges, but its functions at the genome level remain unknown. Here, we obtained the draft genome (1.66 Mbp, 90% estimated genome recovery) of "Ca. Synechococcus spongiarum" strain SH4 inhabiting the Red Sea sponge Carteriospongia foliascens. Phylogenomic analysis revealed a high dissimilarity between SH4 and free-living cyanobacterial strains. Essential functions, such as photosynthesis, the citric acid cycle, and DNA replication, were detected in SH4. Eukaryoticlike domains that play important roles in sponge-symbiont interactions were identified exclusively in the symbiont. However, SH4 could not biosynthesize methionine and polyamines and had lost partial genes encoding low-molecular-weight peptides of the photosynthesis complex, antioxidant enzymes, DNA repair enzymes, and proteins involved in resistance to environmental toxins and in biosynthesis of capsular and extracellular polysaccharides. These genetic modifications imply that "Ca. Synechococcus spongiarum" SH4 represents a low-light-adapted cyanobacterial symbiont and has undergone genome streamlining to adapt to the sponge's mild intercellular environment. 2014 Gao et al.en
dc.language.isoenen
dc.publisherAmerican Society for Microbiologyen
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license (http://creativecommons.org/licenses/by-nc-sa/3.0/) , which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/en
dc.subjectantibiotic agenten
dc.subjectmethionineen
dc.subjectpolyamineen
dc.subjectpolysaccharideen
dc.subjectRNA 16Sen
dc.subjectadaptationen
dc.subjectbacterial genomeen
dc.subjectCandidatus Synechococcus spongiarumen
dc.subjectcyanobacteriumen
dc.subjectDNA extractionen
dc.subjectDNA modificationen
dc.subjectDNA repairen
dc.subjectDNA replicationen
dc.subjectgene lossen
dc.subjectmetagenomeen
dc.subjectnucleotide sequenceen
dc.subjectoxidative stressen
dc.subjectphotosynthesisen
dc.subjectphylogenetic treeen
dc.subjectphylogenomicsen
dc.subjectsymbionten
dc.subjectsymbiosisen
dc.titleSymbiotic adaptation drives genome streamlining of the cyanobacterial sponge symbiont "Candidatus Synechococcus pongiarum"en
dc.typeArticleen
dc.contributor.departmentCoastal and Marine Resources Core Laben
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.identifier.journalmBioen
dc.identifier.pmcidPMC3977351en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDivision of Life Science, The Hong Kong University of Science and Technology, Kowloon, Hong Kongen
dc.contributor.institutionKey Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration (SOA), Xiamen, Chinaen
dc.contributor.institutionSanya Institute of Deep Sea Science and Engineering, Chinese Academy of Sciences, Hainan, Chinaen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorBajic, Vladimir B.en
kaust.authorBatang, Zenon B.en
kaust.authorAl-Suwailem, Abdulaziz M.en

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