Metal-conjugated affinity labels: A new concept to create enantioselective artificial metalloenzymes

Handle URI:
http://hdl.handle.net/10754/325430
Title:
Metal-conjugated affinity labels: A new concept to create enantioselective artificial metalloenzymes
Authors:
Reiner, Thomas; Jantke, Dominik; Marziale, Alexander N.; Raba, Andreas; Eppinger, Jorg ( 0000-0001-7886-7059 )
Abstract:
How to train a protein: Metal-conjugated affinity labels were used to selectively position catalytically active metal centers in the binding pocket of proteases. The resulting artificial metalloenzymes achieve up to 82% e.r. in the hydrogenation of ketones. The modular setup enables a rapid generation of artificial metalloenzyme libraries, which can be adapted to a broad range of catalytic conditions. 2013 The Authors.
KAUST Department:
KAUST Catalysis Center (KCC)
Citation:
Reiner T, Jantke D, Marziale AN, Raba A, Eppinger J (2013) Metal-Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes. ChemistryOpen 2: 50-54. doi:10.1002/open.201200044.
Publisher:
Wiley-Blackwell
Journal:
ChemistryOpen
Issue Date:
20-Feb-2013
DOI:
10.1002/open.201200044
PubMed ID:
24551533
PubMed Central ID:
PMC3646430
Type:
Article
ISSN:
21911363
Appears in Collections:
Articles; KAUST Catalysis Center (KCC)

Full metadata record

DC FieldValue Language
dc.contributor.authorReiner, Thomasen
dc.contributor.authorJantke, Dominiken
dc.contributor.authorMarziale, Alexander N.en
dc.contributor.authorRaba, Andreasen
dc.contributor.authorEppinger, Jorgen
dc.date.accessioned2014-08-27T09:51:02Z-
dc.date.available2014-08-27T09:51:02Z-
dc.date.issued2013-02-20en
dc.identifier.citationReiner T, Jantke D, Marziale AN, Raba A, Eppinger J (2013) Metal-Conjugated Affinity Labels: A New Concept to Create Enantioselective Artificial Metalloenzymes. ChemistryOpen 2: 50-54. doi:10.1002/open.201200044.en
dc.identifier.issn21911363en
dc.identifier.pmid24551533en
dc.identifier.doi10.1002/open.201200044en
dc.identifier.urihttp://hdl.handle.net/10754/325430en
dc.description.abstractHow to train a protein: Metal-conjugated affinity labels were used to selectively position catalytically active metal centers in the binding pocket of proteases. The resulting artificial metalloenzymes achieve up to 82% e.r. in the hydrogenation of ketones. The modular setup enables a rapid generation of artificial metalloenzyme libraries, which can be adapted to a broad range of catalytic conditions. 2013 The Authors.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.rights© 2013 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en
dc.rightsRe-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.en
dc.rightsArchived with thanks to ChemistryOpenen
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/en
dc.subjectAffinity labelsen
dc.subjectArtificial metalloproteinsen
dc.subjectAsymmetric catalysisen
dc.subjectCysteine proteasesen
dc.subjectHydrogenationen
dc.titleMetal-conjugated affinity labels: A new concept to create enantioselective artificial metalloenzymesen
dc.typeArticleen
dc.contributor.departmentKAUST Catalysis Center (KCC)en
dc.identifier.journalChemistryOpenen
dc.identifier.pmcidPMC3646430en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionChemistry Department, Technische Universitt Mnchen, Lichtenbergstr. 4, 85748 Garching, Germanyen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorEppinger, Jorgen
kaust.authorJantke, Dominiken
kaust.authorMarziale, Alexander N.en
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