Innexin gap junctions in nerve cells coordinate spontaneous contractile behavior in Hydra polyps

Handle URI:
http://hdl.handle.net/10754/325397
Title:
Innexin gap junctions in nerve cells coordinate spontaneous contractile behavior in Hydra polyps
Authors:
Takaku, Yasuharu; Hwang, Jung Shan; Wolf, Alexander; Böttger, Angelika; Shimizu, Hiroshi; David, Charles N.; Gojobori, Takashi ( 0000-0001-7850-1743 )
Abstract:
Nerve cells and spontaneous coordinated behavior first appeared near the base of animal evolution in the common ancestor of cnidarians and bilaterians. Experiments on the cnidarian Hydra have demonstrated that nerve cells are essential for this behavior, although nerve cells in Hydra are organized in a diffuse network and do not form ganglia. Here we show that the gap junction protein innexin-2 is expressed in a small group of nerve cells in the lower body column of Hydra and that an anti-innexin-2 antibody binds to gap junctions in the same region. Treatment of live animals with innexin-2 antibody eliminates gap junction staining and reduces spontaneous body column contractions. We conclude that a small subset of nerve cells, connected by gap junctions and capable of synchronous firing, act as a pacemaker to coordinate the contraction of the body column in the absence of ganglia.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Computational Bioscience Research Center (CBRC)
Citation:
Takaku Y, Hwang JS, Wolf A, Böttger A, Shimizu H, et al. (2014) Innexin gap junctions in nerve cells coordinate spontaneous contractile behavior in Hydra polyps. Sci Rep 4. doi:10.1038/srep03573.
Publisher:
Nature Publishing Group
Journal:
Scientific Reports
Issue Date:
7-Jan-2014
DOI:
10.1038/srep03573
PubMed ID:
24394722
PubMed Central ID:
PMC3882753
Type:
Article
ISSN:
20452322
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC); Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorTakaku, Yasuharuen
dc.contributor.authorHwang, Jung Shanen
dc.contributor.authorWolf, Alexanderen
dc.contributor.authorBöttger, Angelikaen
dc.contributor.authorShimizu, Hiroshien
dc.contributor.authorDavid, Charles N.en
dc.contributor.authorGojobori, Takashien
dc.date.accessioned2014-08-27T09:50:38Z-
dc.date.available2014-08-27T09:50:38Z-
dc.date.issued2014-01-07en
dc.identifier.citationTakaku Y, Hwang JS, Wolf A, Böttger A, Shimizu H, et al. (2014) Innexin gap junctions in nerve cells coordinate spontaneous contractile behavior in Hydra polyps. Sci Rep 4. doi:10.1038/srep03573.en
dc.identifier.issn20452322en
dc.identifier.pmid24394722en
dc.identifier.doi10.1038/srep03573en
dc.identifier.urihttp://hdl.handle.net/10754/325397en
dc.description.abstractNerve cells and spontaneous coordinated behavior first appeared near the base of animal evolution in the common ancestor of cnidarians and bilaterians. Experiments on the cnidarian Hydra have demonstrated that nerve cells are essential for this behavior, although nerve cells in Hydra are organized in a diffuse network and do not form ganglia. Here we show that the gap junction protein innexin-2 is expressed in a small group of nerve cells in the lower body column of Hydra and that an anti-innexin-2 antibody binds to gap junctions in the same region. Treatment of live animals with innexin-2 antibody eliminates gap junction staining and reduces spontaneous body column contractions. We conclude that a small subset of nerve cells, connected by gap junctions and capable of synchronous firing, act as a pacemaker to coordinate the contraction of the body column in the absence of ganglia.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rightsThis work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.titleInnexin gap junctions in nerve cells coordinate spontaneous contractile behavior in Hydra polypsen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalScientific Reportsen
dc.identifier.pmcidPMC3882753en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionHamamatsu University School of Medicine, Department of Biology, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japanen
dc.contributor.institutionCenter for Information Biology-DNA Data Bank of Japan, National Institute of Genetics, Mishima 411-8540, Japanen
dc.contributor.institutionHelmholtz Zentrum Mun?chen, German Research Center of Environmental Health, Institute of Molecular Toxicology and Pharmacology, Ingolstdter Landstr. 1, 85764 Neuherberg, Germanyen
dc.contributor.institutionDepartment Biologie II, Ludwig Maximilians University, Munich 80539, Germanyen
dc.contributor.institutionDepartment of Developmental Genetics, National Institute of Genetics, Mishima 411-8540, Japanen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorGojobori, Takashien
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