Plasmon based biosensor for distinguishing different peptides mutation states

Handle URI:
http://hdl.handle.net/10754/325383
Title:
Plasmon based biosensor for distinguishing different peptides mutation states
Authors:
Das, Gobind ( 0000-0003-0942-681X ) ; Chirumamilla, Manohar; Toma, Andrea; Gopalakrishnan, Anisha; Zaccaria, Remo Proietti; Alabastri, Alessandro; Leoncini, Marco; Di Fabrizio, Enzo M. ( 0000-0001-5886-4678 )
Abstract:
Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Physical Sciences and Engineering (PSE) Division
Citation:
Das G, Chirumamilla M, Toma A, Gopalakrishnan A, Zaccaria RP, et al. (2013) Plasmon based biosensor for distinguishing different peptides mutation states. Sci Rep 3. doi:10.1038/srep01792.
Publisher:
Nature Publishing Group
Journal:
Scientific Reports
Issue Date:
8-May-2013
DOI:
10.1038/srep01792
PubMed ID:
23652645
PubMed Central ID:
PMC3647166
Type:
Article
ISSN:
20452322
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorDas, Gobinden
dc.contributor.authorChirumamilla, Manoharen
dc.contributor.authorToma, Andreaen
dc.contributor.authorGopalakrishnan, Anishaen
dc.contributor.authorZaccaria, Remo Proiettien
dc.contributor.authorAlabastri, Alessandroen
dc.contributor.authorLeoncini, Marcoen
dc.contributor.authorDi Fabrizio, Enzo M.en
dc.date.accessioned2014-08-27T09:50:07Z-
dc.date.available2014-08-27T09:50:07Z-
dc.date.issued2013-05-08en
dc.identifier.citationDas G, Chirumamilla M, Toma A, Gopalakrishnan A, Zaccaria RP, et al. (2013) Plasmon based biosensor for distinguishing different peptides mutation states. Sci Rep 3. doi:10.1038/srep01792.en
dc.identifier.issn20452322en
dc.identifier.pmid23652645en
dc.identifier.doi10.1038/srep01792en
dc.identifier.urihttp://hdl.handle.net/10754/325383en
dc.description.abstractPeriodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectBRCA1 proteinen
dc.subjectgolden
dc.subjectmyoglobinen
dc.subjectnanomaterialen
dc.subjectpeptideen
dc.subjectrhodamineen
dc.subjectrhodamine 6Gen
dc.subjectchemistryen
dc.subjectgenetic proceduresen
dc.subjectgeneticsen
dc.subjectmethodologyen
dc.subjectmutationen
dc.subjectsurface plasmon resonanceen
dc.subjectBiosensing Techniquesen
dc.subjectBRCA1 Proteinen
dc.subjectGolden
dc.subjectMutationen
dc.subjectMyoglobinen
dc.subjectNanostructuresen
dc.subjectPeptidesen
dc.subjectRhodaminesen
dc.subjectSurface Plasmon Resonanceen
dc.titlePlasmon based biosensor for distinguishing different peptides mutation statesen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalScientific Reportsen
dc.identifier.pmcidPMC3647166en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionNanostructures, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italyen
dc.contributor.institutionBIONEM Lab, University of Magna Graecia, Campus Salvatore Venuta, Viale Europa 88100, Germaneto-Catanzaro, Italyen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorDi Fabrizio, Enzo M.en

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