Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment

Handle URI:
http://hdl.handle.net/10754/325362
Title:
Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment
Authors:
Essack, Magbubah ( 0000-0003-2709-5356 ) ; Bajic, Vladimir B. ( 0000-0001-5435-4750 ) ; Archer, John A.C. ( 0000-0002-3302-3933 )
Abstract:
Despite intense efforts to develop non-cytotoxic anticancer treatments, effective agents are still not available. Therefore, novel apoptosis-inducing drug leads that may be developed into effective targeted cancer therapies are of interest to the cancer research community. Targeted cancer therapies affect specific aberrant apoptotic pathways that characterize different cancer types and, for this reason, it is a more desirable type of therapy than chemotherapy or radiotherapy, as it is less harmful to normal cells. In this regard, marine sponge derived metabolites that induce apoptosis continue to be a promising source of new drug leads for cancer treatments. A PubMed query from 01/01/2005 to 31/01/2011 combined with hand-curation of the retrieved articles allowed for the identification of 39 recently confirmed apoptosis-inducing anticancer lead compounds isolated from the marine sponge that are selectively discussed in this review. 2011 by the authors.
KAUST Department:
Computational Bioscience Research Center (CBRC)
Citation:
Essack M, Bajic VB, Archer JAC (2011) Recently Confirmed Apoptosis-Inducing Lead Compounds Isolated from Marine Sponge of Potential Relevance in Cancer Treatment. Marine Drugs 9: 1580-1606. doi:10.3390/md9091580.
Publisher:
MDPI AG
Journal:
Marine Drugs
Issue Date:
20-Sep-2011
DOI:
10.3390/md9091580
PubMed ID:
22131960
PubMed Central ID:
PMC3225937
Type:
Article
ISSN:
16603397
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC)

Full metadata record

DC FieldValue Language
dc.contributor.authorEssack, Magbubahen
dc.contributor.authorBajic, Vladimir B.en
dc.contributor.authorArcher, John A.C.en
dc.date.accessioned2014-08-27T09:49:12Z-
dc.date.available2014-08-27T09:49:12Z-
dc.date.issued2011-09-20en
dc.identifier.citationEssack M, Bajic VB, Archer JAC (2011) Recently Confirmed Apoptosis-Inducing Lead Compounds Isolated from Marine Sponge of Potential Relevance in Cancer Treatment. Marine Drugs 9: 1580-1606. doi:10.3390/md9091580.en
dc.identifier.issn16603397en
dc.identifier.pmid22131960en
dc.identifier.doi10.3390/md9091580en
dc.identifier.urihttp://hdl.handle.net/10754/325362en
dc.description.abstractDespite intense efforts to develop non-cytotoxic anticancer treatments, effective agents are still not available. Therefore, novel apoptosis-inducing drug leads that may be developed into effective targeted cancer therapies are of interest to the cancer research community. Targeted cancer therapies affect specific aberrant apoptotic pathways that characterize different cancer types and, for this reason, it is a more desirable type of therapy than chemotherapy or radiotherapy, as it is less harmful to normal cells. In this regard, marine sponge derived metabolites that induce apoptosis continue to be a promising source of new drug leads for cancer treatments. A PubMed query from 01/01/2005 to 31/01/2011 combined with hand-curation of the retrieved articles allowed for the identification of 39 recently confirmed apoptosis-inducing anticancer lead compounds isolated from the marine sponge that are selectively discussed in this review. 2011 by the authors.en
dc.language.isoenen
dc.publisherMDPI AGen
dc.rightsThis article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0en
dc.subjectAnticanceren
dc.subjectApoptosisen
dc.subjectCancer treatmenten
dc.subjectMarine spongeen
dc.subjectTargeted cancer therapyen
dc.subject13e,17e globostellatic acid X methyl esteren
dc.subject5alpha,6alpha epoxy petrosterolen
dc.subjectcandidaspongiolideen
dc.subjectdeath receptoren
dc.subjectdeath receptor type Ien
dc.subjectdeath receptor type IIen
dc.subjectgeoditin Aen
dc.subjectgeoditin Ben
dc.subjectirciniastatin Aen
dc.subjectjaspolide Ben
dc.subjectkuanoniamine Aen
dc.subjectkuanoniamine Cen
dc.subjectleaden
dc.subjectmonanchocidinen
dc.subjectnaamidine Aen
dc.subjectnatural producten
dc.subjectpachastrissamineen
dc.subjectpetrosterol 3,6 dioneen
dc.subjectpsammaplysene Aen
dc.subjectrenieramycin Men
dc.subjectrhabdastrellic acid Aen
dc.subjectrhizochalinen
dc.subjectsalarin Cen
dc.subjectsipholenol Aen
dc.subjectsmenospongineen
dc.subjectsodwanone Ven
dc.subjectspongistatin 1en
dc.subjectstellettin Aen
dc.subjectstellettin Ben
dc.subjectunclassified drugen
dc.subjectunindexed drugen
dc.subjectantineoplastic activityen
dc.subjectapoptosisen
dc.subjectcancer cell destructionen
dc.subjectdrug isolationen
dc.subjectdrug mechanismen
dc.subjectdrug structureen
dc.subjectmarine speciesen
dc.subjectmitochondrial membraneen
dc.subjectmolecularly targeted therapyen
dc.subjectreviewen
dc.subjectsponge (Porifera)en
dc.subjectAlkaloidsen
dc.subjectAntineoplastic Agentsen
dc.subjectLipidsen
dc.subjectMacrolidesen
dc.subjectPoriferaen
dc.subjectTerpenesen
dc.titleRecently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatmenten
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalMarine Drugsen
dc.identifier.pmcidPMC3225937en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionUnidad Académica de Sistemas Arrecifales (Puerto Morelos), Instituto de Ciencias Del Mar y Limnología, Universidad Nacional Autõnoma de México, Puerto Morelos, QR 77580, Mexicoen
dc.contributor.institutionSchool of Natural Sciences, University of California Merced, 5200 North Lake Road, Merced, CA 95343, United Statesen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorEssack, Magbubahen
kaust.authorBajic, Vladimir B.en
kaust.authorArcher, John A.C.en

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