Four new antibacterial xanthones from the marine-derived actinomycetes Streptomyces caelestis

Handle URI:
http://hdl.handle.net/10754/325359
Title:
Four new antibacterial xanthones from the marine-derived actinomycetes Streptomyces caelestis
Authors:
Liu, Ling-Li; Xu, Ying; Han, Zhuang; Li, Yong-Xin; Lu, Liang; Lai, Pok-Yui; Zhong, Jia-Liang; Guo, Xian-Rong; Zhang, Xixiang ( 0000-0002-3478-6414 ) ; Qian, Pei-Yuan
Abstract:
Four new polycyclic antibiotics, citreamicin ? A (1), citreamicin ? B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin ? A (1), citreamicin ? B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 ?g/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. 2012 by the authors; licensee MDPI.
KAUST Department:
Advanced Nanofabrication, Imaging and Characterization Core Lab
Citation:
Liu L-L, Xu Y, Han Z, Li Y-X, Lu L, et al. (2012) Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Marine Drugs 10: 2571-2583. doi:10.3390/md10112571.
Publisher:
MDPI AG
Journal:
Marine Drugs
Issue Date:
20-Nov-2012
DOI:
10.3390/md10112571
PubMed ID:
23203278
PubMed Central ID:
PMC3509536
Type:
Article
ISSN:
16603397
Appears in Collections:
Articles; Advanced Nanofabrication, Imaging and Characterization Core Lab

Full metadata record

DC FieldValue Language
dc.contributor.authorLiu, Ling-Lien
dc.contributor.authorXu, Yingen
dc.contributor.authorHan, Zhuangen
dc.contributor.authorLi, Yong-Xinen
dc.contributor.authorLu, Liangen
dc.contributor.authorLai, Pok-Yuien
dc.contributor.authorZhong, Jia-Liangen
dc.contributor.authorGuo, Xian-Rongen
dc.contributor.authorZhang, Xixiangen
dc.contributor.authorQian, Pei-Yuanen
dc.date.accessioned2014-08-27T09:49:03Z-
dc.date.available2014-08-27T09:49:03Z-
dc.date.issued2012-11-20en
dc.identifier.citationLiu L-L, Xu Y, Han Z, Li Y-X, Lu L, et al. (2012) Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis. Marine Drugs 10: 2571-2583. doi:10.3390/md10112571.en
dc.identifier.issn16603397en
dc.identifier.pmid23203278en
dc.identifier.doi10.3390/md10112571en
dc.identifier.urihttp://hdl.handle.net/10754/325359en
dc.description.abstractFour new polycyclic antibiotics, citreamicin ? A (1), citreamicin ? B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin ? A (1), citreamicin ? B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 ?g/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. 2012 by the authors; licensee MDPI.en
dc.language.isoenen
dc.publisherMDPI AGen
dc.rightsThis article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectAntibacterialen
dc.subjectCitreamicinen
dc.subjectMRSAen
dc.subjectStreptomyces caelestisen
dc.subjectcisplatinen
dc.subjectcitreaglycon Aen
dc.subjectcitreamicin theta Aen
dc.subjectcitreamicin theta Ben
dc.subjectdehydrocitreaglycon Aen
dc.subjectpenicillin Gen
dc.subjectstreptomycinen
dc.subjectunclassified drugen
dc.subjectxanthone derivativeen
dc.subjectActinobacteriaen
dc.subjectantibacterial activityen
dc.subjectBacillus subtilisen
dc.subjectcontrolled studyen
dc.subjectdrug cytotoxicityen
dc.subjectdrug isolationen
dc.subjectdrug structureen
dc.subjectfermentationen
dc.subjectHeLa cellen
dc.subjectmarine bacteriumen
dc.subjectmethicillin resistant Staphylococcus aureusen
dc.subjectminimum inhibitory concentrationen
dc.subjectnuclear magnetic resonanceen
dc.subjectnucleotide sequenceen
dc.subjectStaphylococcus aureusen
dc.subjectStaphylococcus haemolyticusen
dc.subjectAnti-Bacterial Agentsen
dc.subjectBacillus subtilisen
dc.subjectMethicillin-Resistant Staphylococcus aureusen
dc.subjectMicrobial Sensitivity Testsen
dc.subjectStaphylococcus aureusen
dc.subjectStaphylococcus haemolyticusen
dc.subjectStreptomycesen
dc.subjectXanthonesen
dc.subjectActinobacteria (class)en
dc.subjectmethicillin resistant Staphylococcus aureusen
dc.subjectStaphylococcus aureusen
dc.subjectStaphylococcus haemolyticusen
dc.titleFour new antibacterial xanthones from the marine-derived actinomycetes Streptomyces caelestisen
dc.typeArticleen
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Laben
dc.identifier.journalMarine Drugsen
dc.identifier.pmcidPMC3509536en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionDivision of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kongen
dc.contributor.institutionShanghai Institute of Pharmaceutical Industry, Shanghai 200040, Chinaen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorZhang, Xixiangen
kaust.authorGuo, Xianrongen

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