Conotoxins that confer therapeutic possibilities

Handle URI:
http://hdl.handle.net/10754/325357
Title:
Conotoxins that confer therapeutic possibilities
Authors:
Essack, Magbubah ( 0000-0003-2709-5356 ) ; Bajic, Vladimir B. ( 0000-0001-5435-4750 ) ; Archer, John A.C. ( 0000-0002-3302-3933 )
Abstract:
Cone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of these ion channels in normal and diseased states, as well as being a collection of compounds of potential pharmacological use in their own right. Examples include the United States Food and Drug Administration (FDA) approved pharmaceutical drug, Ziconotide (Prialt; Elan Pharmaceuticals, Inc.) that is the synthetic equivalent of the naturally occurring ?-conotoxin MVIIA, whilst several other conotoxins are currently being used as standard research tools and screened as potential therapeutic drugs in pre-clinical or clinical trials. These developments highlight the importance of driving conotoxin-related research. A PubMed query from 1 January 2007 to 31 August 2011 combined with hand-curation of the retrieved articles allowed for the collation of 98 recently identified conotoxins with therapeutic potential which are selectively discussed in this review. Protein sequence similarity analysis tentatively assigned uncharacterized conotoxins to predicted functional classes. Furthermore, conotoxin therapeutic potential for neurodegenerative disorders (NDD) was also inferred. 2012 by the authors; licensee MDPI.
KAUST Department:
Computational Bioscience Research Center (CBRC)
Citation:
Essack M, Bajic VB, Archer JAC (2012) Conotoxins that Confer Therapeutic Possibilities. Marine Drugs 10: 1244-1265. doi:10.3390/md10061244.
Publisher:
MDPI
Journal:
Marine Drugs
Issue Date:
4-Jun-2012
DOI:
10.3390/md10061244
PubMed ID:
22822370
PubMed Central ID:
PMC3397437
Type:
Article
ISSN:
16603397
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC)

Full metadata record

DC FieldValue Language
dc.contributor.authorEssack, Magbubahen
dc.contributor.authorBajic, Vladimir B.en
dc.contributor.authorArcher, John A.C.en
dc.date.accessioned2014-08-27T09:48:58Z-
dc.date.available2014-08-27T09:48:58Z-
dc.date.issued2012-06-04en
dc.identifier.citationEssack M, Bajic VB, Archer JAC (2012) Conotoxins that Confer Therapeutic Possibilities. Marine Drugs 10: 1244-1265. doi:10.3390/md10061244.en
dc.identifier.issn16603397en
dc.identifier.pmid22822370en
dc.identifier.doi10.3390/md10061244en
dc.identifier.urihttp://hdl.handle.net/10754/325357en
dc.description.abstractCone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of these ion channels in normal and diseased states, as well as being a collection of compounds of potential pharmacological use in their own right. Examples include the United States Food and Drug Administration (FDA) approved pharmaceutical drug, Ziconotide (Prialt; Elan Pharmaceuticals, Inc.) that is the synthetic equivalent of the naturally occurring ?-conotoxin MVIIA, whilst several other conotoxins are currently being used as standard research tools and screened as potential therapeutic drugs in pre-clinical or clinical trials. These developments highlight the importance of driving conotoxin-related research. A PubMed query from 1 January 2007 to 31 August 2011 combined with hand-curation of the retrieved articles allowed for the collation of 98 recently identified conotoxins with therapeutic potential which are selectively discussed in this review. Protein sequence similarity analysis tentatively assigned uncharacterized conotoxins to predicted functional classes. Furthermore, conotoxin therapeutic potential for neurodegenerative disorders (NDD) was also inferred. 2012 by the authors; licensee MDPI.en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsThis article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en
dc.subjectCalcium channelen
dc.subjectCone snailen
dc.subjectConotoxinen
dc.subjectConusen
dc.subjectNeuropeptideen
dc.subjectNicotinic acetylcholine receptoren
dc.subjectPeptideen
dc.subjectPotassium channelen
dc.subjectSodium channelen
dc.subjectcalcium channel blocking agenten
dc.subjectcholinergic receptor blocking agenten
dc.subjectconotoxinen
dc.subjectconotoxin BuIIIAen
dc.subjectconotoxin BuIIIBen
dc.subjectconotoxin BuIIICen
dc.subjectconotoxin Cal12ben
dc.subjectconotoxin CalTxen
dc.subjectconotoxin FVIAen
dc.subjectconotoxin GIIIAen
dc.subjectconotoxin KIIIAen
dc.subjectconotoxin Lt5den
dc.subjectconotoxin Lt6cen
dc.subjectconotoxin PIIIAen
dc.subjectconotoxin PrIIIEen
dc.subjectconotoxin Pul4aen
dc.subjectconotoxin RIIIJen
dc.subjectconotoxin SIIIAen
dc.subjectconotoxin SIIIBen
dc.subjectconotoxin Sr11aen
dc.subjectconotoxin TIIIAen
dc.subjectconotoxin Ts14aen
dc.subjection transport affecting agenten
dc.subjectpotassium channel blocking agenten
dc.subjectsodium channel affecting agenten
dc.subjectsodium channel blocking agenten
dc.subjectunclassified drugen
dc.subjectunindexed drugen
dc.subjectvoltage gated calcium channelen
dc.subjectvoltage gated potassium channelen
dc.subjectvoltage gated sodium channelen
dc.subjectconcentration responseen
dc.subjectdrug mechanismen
dc.subjectdrug structureen
dc.subjectdrug targetingen
dc.subjectprotein analysisen
dc.subjectreviewen
dc.subjectsequence analysisen
dc.subjectstructure activity relationen
dc.subjectstructure analysisen
dc.subjectAmino Acid Sequenceen
dc.subjectConotoxinsen
dc.subjectMolecular Sequence Dataen
dc.subjectNeurodegenerative Diseasesen
dc.subjectPeptidesen
dc.subjectSnailsen
dc.subjectVenomsen
dc.subjectGastropodaen
dc.titleConotoxins that confer therapeutic possibilitiesen
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalMarine Drugsen
dc.identifier.pmcidPMC3397437en
dc.eprint.versionPublisher's Version/PDFen
dc.contributor.institutionUnidad Académica de Sistemas Arrecifales (Puerto Morelos), Instituto de Ciencias Del Mar y Limnología, Universidad Nacional Autõnoma de México, Puerto Morelos, QR 77580, Mexicoen
dc.contributor.institutionSchool of Natural Sciences, University of California Merced, 5200 North Lake Road, Merced, CA 95343, United Statesen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorEssack, Magbubahen
kaust.authorBajic, Vladimir B.en
kaust.authorArcher, John A.C.en

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